Panther Pathway: P00013 Cell_Cycle Pathway: An ordered series of events leading to replication of cells. 4.0 s4 PROTEIN p2 s4 PROTEIN p1 s16 PROTEIN p7 s8 PROTEIN p3 s8 PROTEIN p4 s68 PROTEIN p13 s68 PROTEIN p20 s74 PROTEIN p13 s74 PROTEIN p20 s16 PROTEIN p8 SQUARE SQUARE SQUARE OVAL OVAL OVAL OVAL SQUARE active active inactive active inactive inactive active active inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Sethuraman Anand SRI International Mitosis Mid G_sub_1_endsub_ Late G_sub_1_endsub_ Telophase Interphase_br_Prophase Metaphase Anaphase S Phase Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05141 Heterodimer Member Info: Cdk4/6#PROTEIN#Cdk4/6#P00479##;Cyclin D#PROTEIN#Cyclin D#P00484## inside COMPLEX Complex_br_(Cdk4/6/_br_Cyclin D) Long Name: E2F Synonym: Synonym not specified Accession: P00488 inside PROTEIN p4 Long Name: APC Synonym: Synonym not specified Accession: P00481 inside PROTEIN p15 Long Name: ATP Synonym: Synonym not specified Accession: S01614 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01615 inside SIMPLE_MOLECULE ADP Long Name: Proteasome Synonym: Synonym not specified Accession: P00480 inside PROTEIN p17 Long Name: CdkC Synonym: Synonym not specified Accession: P00489 inside PROTEIN p18 Long Name: Pre-replication Complex Synonym: Synonym not specified Accession: P00478 inside PROTEIN p19 Long Name: E2F Synonym: Synonym not specified Accession: P00488 inside PROTEIN p4 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05142 Heterodimer Member Info: Cyclin E#PROTEIN#Cyclin E#P00483##;Cdk2#PROTEIN#Cdk2#P00485## inside COMPLEX Complex_br_(Cyclin E/Cdk2) Long Name: Cyclin E Synonym: Synonym not specified Accession: P00483 inside PROTEIN p8 Long Name: Cdk2 Synonym: Synonym not specified Accession: P00485 inside PROTEIN p7 Long Name: Cdk4/6 Synonym: Synonym not specified Accession: P00479 inside PROTEIN p2 Long Name: Cyclin D Synonym: Synonym not specified Accession: P00484 inside PROTEIN p1 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05144 Heterodimer Member Info: Rb#PROTEIN#Rb#P00487##;E2F#PROTEIN#E2F#P00488## inside COMPLEX Complex_br_(Rb/E2F) Long Name: Rb Synonym: Synonym not specified Accession: P00487 inside PROTEIN p3 Long Name: Rb Synonym: Synonym not specified Accession: P00487 inside PROTEIN p3 Long Name: Protein kinase subunit Synonym: Synonym not specified Accession: P00482 inside PROTEIN p13 Long Name: APC Synonym: Synonym not specified Accession: P00481 inside PROTEIN p15 Long Name: Cyclin B Synonym: Synonym not specified Accession: P00486 inside PROTEIN p20 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05140 Heterodimer Member Info: Protein kinase subunit#PROTEIN#Protein kinase subunit#P00482##;Cyclin B#PROTEIN#Cyclin B#P00486## inside COMPLEX Complex_br_(Protein_br_kinase_br_subunit/Cyclin B) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05143 Heterodimer Member Info: Protein kinase subunit#PROTEIN#Protein kinase subunit#P00482##;Cyclin B#PROTEIN#Cyclin B#P00486## inside COMPLEX Complex_br_(Protein_br_kinase_br_subunit/Cyclin B) Long Name: Cyclin B Synonym: Synonym not specified Accession: P00486 inside PROTEIN p20 Long Name: a102_degraded Synonym: Synonym not specified Accession: U02199 inside DEGRADED a102_degraded Long Name: Cyclin B Synonym: Synonym not specified Accession: P00486 inside PROTEIN p20 STATE_TRANSITION a21 a31 a31 STATE_TRANSITION a70 a69 a68 HETERODIMER_ASSOCIATION 0.3840269188087344,0.24839394013319716 a76 a77 a12 DISSOCIATION 0.4313792749185943,0.31881007579892007 a12 a78 a21 a30 a6 HETERODIMER_ASSOCIATION 0.2920490479774642,0.36419337763136106 a81 a80 a30 a31 HETERODIMER_ASSOCIATION 0.3741850370074875,0.2956774517909533 a83 a84 a6 HETERODIMER_ASSOCIATION 0.5987205635512437,0.34385295158812945 a92 a91 a93 STATE_TRANSITION 0.31034586351907345,0.0015992110622096156 0.6228942150433006,-0.0021109828307204204 a94 a47 a46 a48 a93 STATE_TRANSITION a93 a98 a46 STATE_TRANSITION a102 a103 a67 STATE_TRANSITION a104 a91 DISSOCIATION 0.7709016239791935,-0.04755761008453918 a98 a102 a92 UNKNOWN_TRANSITION a98 a104