This pathway illustrates the events of cholesterol biosynthesis from acetyl CoA to lanosterol. There are an additional nine steps from lanosterol to cholesterol, which are not included here at this time.; Medline=1390320 Medline=3524618 4.0 inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Long Name: Mevalonate Synonym: Synonym not specified Accession: S01624 inside SIMPLE_MOLECULE Mevalonate Long Name: ATP Synonym: Synonym not specified Accession: S01623 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01628 inside SIMPLE_MOLECULE ADP Long Name: PPi Synonym: Synonym not specified Accession: U02201 inside ION PPi Long Name: Squalene Synonym: Synonym not specified Accession: S01630 inside SIMPLE_MOLECULE Squalene Long Name: Lanosterol Synonym: Synonym not specified Accession: S01616 inside SIMPLE_MOLECULE Lanosterol Long Name: Cholesterol Synonym: Synonym not specified Accession: S01631 inside SIMPLE_MOLECULE Cholesterol Long Name: Squalene monooxygenase Synonym: squalene epoxidase Accession: P00494 inside PROTEIN p10 Long Name: Farnesyl-diphosphate farnesyltransferase Synonym: farnesyltransferase,presqualene-di-diphosphate synthase,squalene synthase Accession: P00499 inside PROTEIN p9 Long Name: Farsenyl pyrophosphate Synonym: Synonym not specified Accession: S01632 inside SIMPLE_MOLECULE Farsenyl_space_pyrophosphate Long Name: Acetoacetyl CoA Synonym: Synonym not specified Accession: S01639 inside SIMPLE_MOLECULE Acetoacetyl_space_CoA Long Name: Acetyl CoA Synonym: Synonym not specified Accession: S01620 inside SIMPLE_MOLECULE Acetyl_space_CoA Long Name: H2O Synonym: Synonym not specified Accession: S01638 inside SIMPLE_MOLECULE H_sub_2_endsub_O Long Name: CoA-SH Synonym: Synonym not specified Accession: S01634 inside SIMPLE_MOLECULE CoA_minus_SH Long Name: Hydroxymethyl glutaryl CoA synthase Synonym: Synonym not specified Accession: P00498 inside PROTEIN p1 Long Name: 3-hydroxy-3-methyl-glutaryl CoA Synonym: Synonym not specified Accession: S01637 inside SIMPLE_MOLECULE 3_minus_hydroxy_minus_3_minus_methyl_minus_glutaryl_space_CoA Long Name: Mg++ Synonym: Synonym not specified Accession: U02200 inside ION Mg_super__plus__plus__endsuper_ Long Name: 2NADPH + H Synonym: Synonym not specified Accession: S01622 inside SIMPLE_MOLECULE 2NADPH_space__plus__space_H Long Name: 2NADP + CoA-SH Synonym: Synonym not specified Accession: S01618 inside SIMPLE_MOLECULE 2NADP_space__plus__space_CoA_minus_SH Long Name: Hydroxymethyl glutaryl CoA reductase Synonym: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Accession: P00491 inside PROTEIN p2 Long Name: Mevalonate-5-phosphate Synonym: Synonym not specified Accession: S01633 inside SIMPLE_MOLECULE Mevalonate_minus_5_minus_phosphate Long Name: Phosphomevalonate kinase Synonym: Synonym not specified Accession: P00500 inside PROTEIN p4 Long Name: Mevalonate kinase Synonym: Synonym not specified Accession: P00492 inside PROTEIN p3 Long Name: Mevalonate-5-pyrophosphate Synonym: Synonym not specified Accession: S01621 inside SIMPLE_MOLECULE Mevalonate_minus_5_minus_pyrophosphate Long Name: Diphosphomevalonate decarboxylase Synonym: Synonym not specified Accession: P00496 inside PROTEIN p5 Long Name: delta3-isopentenyl pyrophosphate Synonym: Synonym not specified Accession: S01626 inside SIMPLE_MOLECULE _delta_3_minus_isopentenyl_space_pyrophosphate Long Name: Isopentenyl diphosphate delta-isomerase Synonym: IPP isomerase,isopentenyl pyrophosphate isomerase,isopentenylpyrophosphate delta-isomerase,methylbutenylpyrophosphate isomerase Accession: P00495 inside PROTEIN p6 Long Name: Dimethylallyl pyrophosphate Synonym: Synonym not specified Accession: S01635 inside SIMPLE_MOLECULE Dimethylallyl_space_pyrophosphate Long Name: Dimethylallyl trans-transferase Synonym: dimethylallyltransferase,geranyl-diphosphate synthase,prenyltransferase Accession: P00490 inside PROTEIN p7 Long Name: Geranyl pyrophosphate Synonym: Synonym not specified Accession: S01617 inside SIMPLE_MOLECULE Geranyl_space_pyrophosphate Long Name: Geranyl trans-transferase Synonym: FPP synthetase,farnesyl diphosphate synthetase,farnesyl pyrophosphate synthetase,farnesyl-diphosphate synthase Accession: P00493 inside PROTEIN p8 Long Name: NADPH + H+ Synonym: Synonym not specified Accession: S01625 inside SIMPLE_MOLECULE NADPH_space__plus__space_H_super__plus_ Long Name: NADP+ Synonym: Synonym not specified Accession: S01619 inside SIMPLE_MOLECULE NADP_super__plus_ Long Name: NADPH + H+ O2 Synonym: Synonym not specified Accession: S01627 inside SIMPLE_MOLECULE NADPH_space__plus__space_H_super__plus__endsuper__space_O_sub_2 Long Name: NADP + H2O Synonym: Synonym not specified Accession: S01629 inside SIMPLE_MOLECULE NADP_space__plus__space_H_sub_2_endsub_O Long Name: Anosterol synthase Synonym: Lanosterol synthase Accession: P00497 inside PROTEIN p11 Long Name: Squalene 2,3 epoxide Synonym: Synonym not specified Accession: S01636 inside SIMPLE_MOLECULE Squalene_space_2,3_space_epoxide STATE_TRANSITION a2 a19 a3 a20 a10 STATE_TRANSITION a3 a22 a24 a4 a23 a11 STATE_TRANSITION a4 a25 a29 a6 a27 a12 STATE_TRANSITION a6 a26 a30 a5 a28 a13 STATE_TRANSITION a5 a31 a7 a14 STATE_TRANSITION a7 a32 a8 a33 a15 STATE_TRANSITION 0.5436357146638456,0.14285783557299947 0.8139807931531821,0.2041444019694283 0.9398068673487118,0.2389959649628266 a8 a46 a34 a47 a39 STATE_TRANSITION 0.32290736226969186,-0.0010597550451905136 0.7237480410684274,0.004767654388159848 a34 a45 a43 a35 a44 a40 STATE_TRANSITION a35 a48 a36 a49 a41 STATE_TRANSITION a36 a37 a42 HETERODIMER_ASSOCIATION 0.3676134386958898,0.2671089906068287 a51 a50 a16 a2 a18 a9 KNOWN_TRANSITION_OMITTED a37 a38