Panther Pathway: P04380 15134857 4.0 s10 SIMPLE_MOLECULE GTP s10 PROTEIN p8 s24 SIMPLE_MOLECULE GDP s24 PROTEIN p8 s24 PROTEIN p3 s26 SIMPLE_MOLECULE GDP s26 PROTEIN p8 s26 PROTEIN p3 s26 PROTEIN p2 s27 PROTEIN p3 s27 PROTEIN p2 s50 ION Ca_super_2+ s50 PROTEIN p11 SQUARE SQUARE SQUARE SQUARE_CLOSEUP_SOUTH SQUARE SQUARE SQUARE active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive SRI International Endoplasmic Reticulum Secretory Vesicle Parvocellular cells in PVN (also: preoptic areas, olfactory bulbs, central amyglada, layer 2/3 neocortex etc) Corticotrophs (cells in anterior pituitary) nucleus endoplasmic reticulum Long Name: GDP Synonym: Synonym not specified Accession: S04768 inside SIMPLE_MOLECULE GDP Long Name: GTP Synonym: Synonym not specified Accession: S04767 inside SIMPLE_MOLECULE GTP Long Name: Long name not specified Synonym: Synonym not specified Accession: U05152 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S04767##;G-Protein#PROTEIN#G-Protein#P04458## inside COMPLEX Complex_br_(GTP/G-Protein) Long Name: SNARE COMPLEX Synonym: Synonym not specified Accession: P04457 transmembrane PROTEIN p11 Long Name: ACTH Synonym: Synonym not specified Accession: P04453 inside PROTEIN p5 Long Name: Corticotropin-releasing factor Synonym: Synonym not specified Accession: P04454 inside PROTEIN p2 Long Name: Corticotropin-releasing factor Synonym: Synonym not specified Accession: P04454 inside PROTEIN p2 Long Name: Pro Corticotropin-releasing factor Synonym: Synonym not specified Accession: P04456 inside PROTEIN p1 Long Name: Stress Synonym: Synonym not specified Accession: U05157 inside UNKNOWN Stress Long Name: Long name not specified Synonym: Synonym not specified Accession: U05150 Heterodimer Member Info: CRHR1#PROTEIN#CRHR1#P04451##;G-Protein#PROTEIN#G-Protein#P04458##;GDP#SIMPLE_MOLECULE#GDP#S04768## transmembrane COMPLEX Complex_br_(GDP/G-Protein/_br_TRH Receptor) Long Name: Long name not specified Synonym: Synonym not specified Accession: U05154 Heterodimer Member Info: CRHR1#PROTEIN#CRHR1#P04451##;CRF#PROTEIN#Corticotropin-releasing factor#P04454##;G-Protein#PROTEIN#G-Protein#P04458##;GDP#SIMPLE_MOLECULE#GDP#S04768## transmembrane COMPLEX Complex_br_(GDP/G-Protein/_br_TRH Receptor/CRF) Long Name: type 1 plasma membrane receptors Synonym: Synonym not specified Accession: U05151 Heterodimer Member Info: CRHR1#PROTEIN#CRHR1#P04451##;CRF#PROTEIN#Corticotropin-releasing factor#P04454## transmembrane COMPLEX Complex_br_(TRH Receptor/CRF) Long Name: Long name not specified Synonym: Synonym not specified Accession: U05153 Heterodimer Member Info: Ca2+#ION#Ca2+#U05155##;SNARE COMPLEX#PROTEIN#SNARE COMPLEX#P04457## transmembrane COMPLEX Complex_br_(Ca_super_2+/SNARE COMPLEX) Long Name: beta-endorphin Synonym: Synonym not specified Accession: P04455 inside PROTEIN p12 Long Name: ACTH Synonym: Synonym not specified Accession: P04453 inside PROTEIN p5 Long Name: beta-endorphin Synonym: Synonym not specified Accession: P04455 inside PROTEIN p12 Long Name: proopiomelanocortin Synonym: LIPOTROPIN, INCLUDED,MELANOCYTE-STIMULATING HORMONE, INCLUDED,MELANOTROPIN, INCLUDED,POC,PRO-ACTH-ENDORPHIN Accession: G04671 inside RNA rn1 Long Name: proopiomelanocortin Synonym: LIPOTROPIN, INCLUDED,MELANOCYTE-STIMULATING HORMONE, INCLUDED,MELANOTROPIN, INCLUDED,POC,POMC,PRO-ACTH-ENDORPHIN Accession: P04452 inside PROTEIN p13 Long Name: pain reduction Synonym: Synonym not specified Accession: U05158 inside PHENOTYPE pain reduction Long Name: release of glutocorticoids and epinephrine Synonym: Synonym not specified Accession: U05156 inside PHENOTYPE release of glutocorticoids and epinephrine inside DEGRADED s66 UNKNOWN_TRANSITION a1 a35 TRANSPORT 0.3193921465470768,0.006312375569828443 a35 a2 a34 a49 HETERODIMER_ASSOCIATION 0.6552371978576286,0.011592751793386036 -0.16685775498314626,0.3719010494579691 a2 a37 a40 DISSOCIATION 0.22879252868017375,0.0018161755423218295 0.6300076213199057,-0.0018343054978053885 0.3380127209729118,0.29561317374921137 a40 a7 a41 a11 a6 TRANSPORT 0.5470883127633073,-0.0015484062367550067 a61 a62 a60 TRANSPORT 0.45844646606018413,0.0013239484944636004 a46 a63 a60 DISSOCIATION 0.27110162950629135,0.4728516793714377 a67 a61 a46 TRANSCRIPTION sa30 a66 a11 TRANSLATION a66 a67 PHYSICAL_STIMULATION a63 a69 PHYSICAL_STIMULATION a62 a68