Panther Pathway: P05730 No pathway definition Medline=15936806 Medline=12843414 Medline=15525797 PMID: 12843414 PMID: 15525797 PMID: 15936806 4.0 Long Name: Metabotropic glutamate receptor 1/5 Synonym: mGlu5,mGluR1,mGlu1,mGluR5,GRM5,mGlu 1,mGlu 5 Accession: P05748 s38 PROTEIN pr4 Long Name: G protein Synonym: Synonym not specified Accession: P05747 s38 PROTEIN pr5 Long Name: GTP Synonym: Synonym not specified Accession: S05805 s32 SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S05803 s38 SIMPLE_MOLECULE GDP Long Name: G protein Synonym: Synonym not specified Accession: P05747 s32 PROTEIN pr5 Long Name: Cannabinoid receptor 1 Synonym: CNR1 Accession: P05743 s43 PROTEIN pr1 Long Name: Gbeta Synonym: Synonym not specified Accession: P05745 s54 PROTEIN p5 Long Name: Ggamma Synonym: Synonym not specified Accession: P05744 s54 PROTEIN p9 Long Name: Gbeta Synonym: Synonym not specified Accession: P05745 s43 PROTEIN p5 Long Name: Ggamma Synonym: Synonym not specified Accession: P05744 s43 PROTEIN p9 Long Name: Gi/oalpha Synonym: Synonym not specified Accession: P05751 s43 PROTEIN p3 Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P05749 s64 PROTEIN p10 Long Name: Ca2+ Synonym: Synonym not specified Accession: U05882 s64 ION Ca_super_2+ Long Name: Glutamate Synonym: Synonym not specified Accession: S05808 s38 SIMPLE_MOLECULE Glutamate Long Name: This could be 2-AG, anandamide, or any kind of endogenouse cannabinoid molecules. Many of these experiments were also done on CB1 receptor agonists, such as WIN5,212-2, or antagonists, such as SR141716 and AM281. Synonym: Synonym not specified Accession: S05807 s43 SIMPLE_MOLECULE endocannabinoid Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P05749 s80 PROTEIN p10 Long Name: Ca2+ Synonym: Synonym not specified Accession: U05882 s80 ION Ca_super_2+ SQUARE_CLOSEUP_NORTHEAST SQUARE_CLOSEUP_SOUTHEAST SQUARE_CLOSEUP_WEST OVAL OVAL inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive SRI International postsynaptic Presynaptic Glia Synaptic vesicle_br_(glutaminergic) Synaptic vesicle_br_(GABAergic) Long Name: anandamide Synonym: Synonym not specified Accession: S05806 inside SIMPLE_MOLECULE anandamide Long Name: anandamide Synonym: Synonym not specified Accession: S05806 inside SIMPLE_MOLECULE anandamide Long Name: Cannabinoid receptor 1 Synonym: CNR1 Accession: P05743 transmembrane PROTEIN pr1 Long Name: phospholipase C Synonym: Phosphoinositidase C Accession: P05746 inside PROTEIN pr6 Long Name: 2-AG Synonym: Synonym not specified Accession: S05804 inside SIMPLE_MOLECULE 2-AG Long Name: G protein GTP complex Synonym: Synonym not specified Accession: U05874 inside COMPLEX G protein_br_GTP complex Long Name: 2-AG Synonym: Synonym not specified Accession: S05804 inside SIMPLE_MOLECULE 2-AG Long Name: mGluR G protein complex Synonym: Synonym not specified Accession: U05875 transmembrane COMPLEX mGluR_br_G protein complex Long Name: Metabotropic glutamate receptor 1/5 Synonym: mGlu5,mGluR1,mGlu1,mGluR5,GRM5,mGlu 1,mGlu 5 Accession: P05748 transmembrane PROTEIN pr4 Long Name: GDP Synonym: Synonym not specified Accession: S05803 inside SIMPLE_MOLECULE GDP Long Name: GTP Synonym: Synonym not specified Accession: S05805 inside SIMPLE_MOLECULE GTP Long Name: CB1/2AG complex Synonym: Synonym not specified Accession: U05876 transmembrane COMPLEX CB1_slash_2AG_br_complex Long Name: Gi/oalpha Synonym: Synonym not specified Accession: P05751 inside PROTEIN p3 Long Name: Voltage-dependent Ca channel Synonym: Synonym not specified Accession: P05750 transmembrane PROTEIN pr10 Long Name: Gbetagamma complex Synonym: Synonym not specified Accession: U05877 inside COMPLEX G_beta__gamma_ complex Long Name: Gi/oalpha Synonym: Synonym not specified Accession: P05751 inside PROTEIN p3 Long Name: Ca2+ Synonym: Synonym not specified Accession: U05882 inside ION Ca_super_2_plus_ Long Name: Ca2+ Synonym: Synonym not specified Accession: U05882 inside ION Ca_super_2_plus_ Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05878 transmembrane COMPLEX Complex_br_(SNARE Complex/Ca_super_2+) Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P05749 transmembrane PROTEIN p10 Long Name: Glutamate Synonym: Synonym not specified Accession: S05808 inside SIMPLE_MOLECULE Glutamate Long Name: Voltage-dependent Ca channel Synonym: Synonym not specified Accession: P05750 transmembrane PROTEIN pr10 Long Name: Ca2+ Synonym: Synonym not specified Accession: U05882 inside ION Ca_super_2_plus_ Long Name: Depolarization Synonym: Synonym not specified Accession: U05885 inside PHENOTYPE Depolarization Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05879 transmembrane COMPLEX Complex_br_(SNARE Complex/Ca_super_2+) Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P05749 transmembrane PROTEIN p10 Long Name: Glutamate Synonym: Synonym not specified Accession: S05802 inside SIMPLE_MOLECULE GABA Long Name: Glutamate Synonym: Synonym not specified Accession: S05802 inside SIMPLE_MOLECULE GABA Long Name: GABA-B receptor II pathway Synonym: Synonym not specified Accession: U05886 inside PHENOTYPE GABA-B receptor II pathway Long Name: Glutamate Synonym: Synonym not specified Accession: S05808 inside SIMPLE_MOLECULE Glutamate Long Name: anandamide Synonym: Synonym not specified Accession: S05806 inside SIMPLE_MOLECULE anandamide Long Name: anandamide Synonym: Synonym not specified Accession: S05806 inside SIMPLE_MOLECULE anandamide inside DEGRADED sa70_degraded inside DEGRADED sa69_degraded inside DEGRADED s94 inside DEGRADED s95 TRANSPORT sa1 sa2 STATE_TRANSITION sa16 sa27 csa3 TRANSPORT sa23 sa28 DISSOCIATION 0.3120597111771293,-8.026754536594183E-6 0.5787753337491122,-0.004420705152591076 0.029504083081404175,0.6173331167625422 csa4 sa33 sa31 csa3 sa32 HETERODIMER_ASSOCIATION 0.5606910321343825,0.2825219192998176 sa3 sa28 csa5 STATE_TRANSITION 0.7359558853125492,-3.2200501791379565E-4 sa40 sa39 csa7 DISSOCIATION 0.033138101109742024,0.712584771886557 csa5 csa7 sa36 STATE_TRANSITION sa36 sa41 HETERODIMER_ASSOCIATION 0.66618808661264,0.3816055602050423 sa41 csa7 csa5 TRANSPORT sa47 sa48 sa39 HETERODIMER_ASSOCIATION -0.2832784613283117,0.4710663924772982 sa52 sa48 csa8 TRANSPORT 0.4107348022070352,-0.0021367941490826325 sa51 sa49 csa8 HETERODIMER_ASSOCIATION 0.7087353142042105,0.29117936372530506 sa49 sa31 csa4 STATE_TRANSITION sa57 sa56 TRANSPORT sa59 sa58 sa56 HETERODIMER_ASSOCIATION 0.28985133737702506,0.3273923685534843 sa3 sa2 csa5 TRANSPORT 0.454630720969448,3.3306690738754696E-16 sa63 sa65 csa9 HETERODIMER_ASSOCIATION 0.2649775678232691,-0.16632092736954207 0.36135754347330984,0.5010009452429505 sa48 sa64 csa9 PHYSICAL_STIMULATION sa65 sa68 TRIGGER sa58 sa60 TRANSPORT sa2 sa70 TRANSPORT sa2 sa69 STATE_TRANSITION sa70 sa71 STATE_TRANSITION sa69 sa72 KNOWN_TRANSITION_OMITTED sa73 sa23 sa27 KNOWN_TRANSITION_OMITTED sa74 sa1 sa58