The biosynthesis of heme, a Fe+2 containing cofactor critical for the binding and transport of oxygen. Website=www.biocyc.org/Ecoli/Pathways/ free text=Biochemistry (text) Voet and Voet 4.0 inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Long Name: glutamate Synonym: Synonym not specified Accession: S03703 inside SIMPLE_MOLECULE glutamate Long Name: ATP Synonym: Synonym not specified Accession: S03689 inside SIMPLE_MOLECULE ATP Long Name: tRNAglu Synonym: Synonym not specified Accession: S03698 inside SIMPLE_MOLECULE tRNA_super_glu Long Name: glutamyl-tRNAglu Synonym: Synonym not specified Accession: S03682 inside SIMPLE_MOLECULE glutamyl-tRNA_super_glu Long Name: NADPH Synonym: Synonym not specified Accession: S03704 inside SIMPLE_MOLECULE NADPH Long Name: NADP Synonym: Synonym not specified Accession: S03684 inside SIMPLE_MOLECULE NADP Long Name: H2O Synonym: Synonym not specified Accession: S03705 inside SIMPLE_MOLECULE H_sub_2_endsub_O Long Name: porphobilinogen Synonym: Synonym not specified Accession: S03678 inside SIMPLE_MOLECULE porphobilinogen Long Name: NH3 Synonym: Synonym not specified Accession: S03686 inside SIMPLE_MOLECULE NH_sub_3 Long Name: hydroxymethylbilane Synonym: Synonym not specified Accession: S03708 inside SIMPLE_MOLECULE hydroxymethylbilane Long Name: AMP Synonym: Synonym not specified Accession: S03697 inside SIMPLE_MOLECULE AMP Long Name: PPi Synonym: Synonym not specified Accession: S03707 inside SIMPLE_MOLECULE PP_sub_i Long Name: sirohydrochlorin Synonym: Synonym not specified Accession: S03685 inside SIMPLE_MOLECULE sirohydrochlorin Long Name: siroheme Synonym: Synonym not specified Accession: S03690 inside SIMPLE_MOLECULE siroheme Long Name: Fe2+ Synonym: Synonym not specified Accession: S03702 inside SIMPLE_MOLECULE Fe_super_2+ Long Name: 2 H+ Synonym: Synonym not specified Accession: S03700 inside SIMPLE_MOLECULE 2 H_super_+ Long Name: NAD Synonym: Synonym not specified Accession: S03681 inside SIMPLE_MOLECULE NAD Long Name: NADH Synonym: Synonym not specified Accession: S03687 inside SIMPLE_MOLECULE NADH Long Name: Dimethyluroporphyrinogen-III dehydrogenase Synonym: Synonym not specified Accession: P02969 inside PROTEIN p2 Long Name: Uroporphyrinogen methyltransferase Synonym: Synonym not specified Accession: P02973 inside PROTEIN p1 Long Name: Siroheme ferrochelatase Synonym: Synonym not specified Accession: P02971 inside PROTEIN p3 Long Name: glutamate-1-semialdehyde Synonym: Synonym not specified Accession: S03680 inside SIMPLE_MOLECULE glutamate-1-_br_semialdehyde Long Name: Glutamyl-tRNA reductase Synonym: Synonym not specified Accession: P02978 inside PROTEIN p5 Long Name: Glutamyl-tRNA-synthetase Synonym: Synonym not specified Accession: P02977 inside PROTEIN p4 Long Name: Glutamate-1-semialdehyde 2,1-aminomutase Synonym: Synonym not specified Accession: P02981 inside PROTEIN p6 Long Name: porphobilinogen synthase Synonym: Synonym not specified Accession: P02979 inside PROTEIN p7 Long Name: Hydroxymethylbilane synthase Synonym: Synonym not specified Accession: P02983 inside PROTEIN p8 Long Name: SAM Synonym: Synonym not specified Accession: S03693 inside SIMPLE_MOLECULE SAM Long Name: SA-homocysteine Synonym: Synonym not specified Accession: S03683 inside SIMPLE_MOLECULE SA-homocysteine Long Name: coproporphyrinogen III Synonym: Synonym not specified Accession: S03701 inside SIMPLE_MOLECULE coproporphyrinogen III Long Name: 2 O2 Synonym: Synonym not specified Accession: S03710 inside SIMPLE_MOLECULE 2 O_sub_2 Long Name: 2 H2O2 Synonym: Synonym not specified Accession: S03692 inside SIMPLE_MOLECULE 2 H_sub_2_endsub_O_sub_2 Long Name: 2 CO2 Synonym: Synonym not specified Accession: S03694 inside SIMPLE_MOLECULE 2 CO_sub_2 Long Name: protoporphyrinogen Synonym: Synonym not specified Accession: S03709 inside SIMPLE_MOLECULE protoporphyrinogen Long Name: O2 Synonym: Synonym not specified Accession: S03706 inside SIMPLE_MOLECULE O_sub_2 Long Name: 2 H2O Synonym: Synonym not specified Accession: S03676 inside SIMPLE_MOLECULE 2 H_sub_2_endsub_O Long Name: 2 H+ Synonym: Synonym not specified Accession: S03699 inside SIMPLE_MOLECULE 2 H_super_+ Long Name: protoporphyrin IX Synonym: Synonym not specified Accession: S03679 inside SIMPLE_MOLECULE protoporphyrin IX Long Name: protoheme Synonym: Synonym not specified Accession: S03677 inside SIMPLE_MOLECULE protoheme Long Name: Heme Synonym: Synonym not specified Accession: S03675 inside SIMPLE_MOLECULE Heme Long Name: FDP Synonym: Synonym not specified Accession: S03674 inside SIMPLE_MOLECULE FDP Long Name: 4 CO2 Synonym: Synonym not specified Accession: S03691 inside SIMPLE_MOLECULE 4 CO_sub_2 Long Name: Uroporphyrinogen decarboxylase Synonym: Synonym not specified Accession: P02975 inside PROTEIN p10 Long Name: Coproporphyrinogen oxidase (oxygen independent) Synonym: Synonym not specified Accession: P02970 inside PROTEIN p12 Long Name: Coproporphyrinogen Oxidase (oxygen dependent) Synonym: Synonym not specified Accession: P02980 inside PROTEIN p11 Long Name: Ferrochelatase Synonym: Synonym not specified Accession: P02972 inside PROTEIN p13 Long Name: Protoheme IX farnesyl transferase Synonym: Synonym not specified Accession: P02982 inside PROTEIN p14 Long Name: Protoporphyrinogen oxidase Synonym: Synonym not specified Accession: P02976 inside PROTEIN p15 Long Name: 5-amino-leulinate Synonym: Synonym not specified Accession: S03688 inside SIMPLE_MOLECULE 5-amino-levulinate Long Name: uropophpyrinogen-III Synonym: Synonym not specified Accession: S03695 inside SIMPLE_MOLECULE uroporphyrinogen-III Long Name: dihydroirohydrochlorin Synonym: Synonym not specified Accession: S03696 inside SIMPLE_MOLECULE dihydrosirohydrochlorin Long Name: Uroporphyrinogen-III synthase Synonym: Synonym not specified Accession: P02974 inside PROTEIN p9 STATE_TRANSITION 0.33333333333333304,0.0 0.6666666666666661,0.0 a1 a2 a3 a4 a17 a18 a31 STATE_TRANSITION 0.3333333333333335,0.0 0.6666666666666665,-2.220446049250313E-16 a4 a5 a8 a6 a7 a32 STATE_TRANSITION 0.3333333333333335,0.0 0.666666666666667,0.0 a8 a9 a33 STATE_TRANSITION 0.3333333333333337,-2.220446049250313E-16 0.666666666666667,0.0 a9 a11 a15 a34 STATE_TRANSITION 0.3333333333333333,0.0 0.6666666666666667,0.0 a14 a16 a12 a36 STATE_TRANSITION 0.33333333333333315,0.0 0.6666666666666663,-4.440892098500626E-16 a16 a26 a19 a27 a28 STATE_TRANSITION 0.3333333333333335,0.0 0.6666666666666663,-8.881784197001252E-16 a19 a24 a20 a25 a29 STATE_TRANSITION 0.3333333333333335,0.0 0.666666666666667,0.0 a20 a22 a21 a23 a30 STATE_TRANSITION 0.3333333333333339,0.0 0.666666666666667,0.0 a11 a10 a14 a13 a35 STATE_TRANSITION 0.3333333333333335,0.0 0.6666666666666665,-8.881784197001252E-16 a16 a37 a53 a54 STATE_TRANSITION 0.33333333333333304,4.440892098500626E-16 0.6666666666666661,-4.440892098500626E-16 a37 a43 STATE_TRANSITION 0.33333333333333304,4.440892098500626E-16 0.6666666666666661,-4.440892098500626E-16 a37 a38 a40 a43 a39 a41 a42 a55 a56 STATE_TRANSITION 0.33333333333333215,8.881784197001252E-16 0.6666666666666661,1.7763568394002505E-15 a43 a44 a48 a45 a59 STATE_TRANSITION 0.33333333333333215,-8.881784197001252E-16 0.6666666666666661,-8.881784197001252E-16 a48 a46 a49 a47 a57 STATE_TRANSITION 0.3333333333333339,8.881784197001252E-16 0.6666666666666679,-8.881784197001252E-16 a49 a51 a50 a52 a58