Panther Pathway: P00027 Gq alpha and Go alpha mediated pathways are G-protein receptor activated pathways. A number of activated receptors can bind to and activate the associated heterotrimeric G-protein consisting of either Gq alpha or Go alpha. The activated, GTP-bound G alpha subunit dissociates from its cognate beta gamma subunit and is free to effect downstream signaling molecules. In the case of Gq alpha, the downstream molecules Rho-GEF and Phospholipase C-beta are activated. In the case of Go alpha, calcium channels and G-protein inwardly rectifying potassium channels are activated and RAP1GAP is inhibited. 4.0 s10 PROTEIN p5 s10 PROTEIN p9 s1 SIMPLE_MOLECULE Ligand s1 PROTEIN p1 s84 PROTEIN p7 s70 PROTEIN p4 s70 PROTEIN p5 s70 PROTEIN p9 s79 PROTEIN p2 s79 SIMPLE_MOLECULE Ligand s60 PROTEIN p4 s60 PROTEIN p5 s60 PROTEIN p9 s77 SIMPLE_MOLECULE Ligand s77 PROTEIN p2 s77 PROTEIN p4 s77 PROTEIN p9 s77 PROTEIN p5 s23 PROTEIN p3 s23 PROTEIN p5 s23 PROTEIN p9 s5 PROTEIN p1 s5 PROTEIN p3 s5 PROTEIN p5 s5 PROTEIN p9 s5 SIMPLE_MOLECULE Ligand s11 PROTEIN p3 s11 PROTEIN p5 s11 PROTEIN p9 s84 PROTEIN p1 Long Name: Gq-protein coupled receptor Synonym: GqPCR Accession: P00730 s11 PROTEIN p1 Long Name: Go-protein coupled receptor Synonym: GoPCR Accession: P00725 s60 PROTEIN p2 s88 PROTEIN p2 s88 PROTEIN p7 SQUARE SQUARE active active inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive active active inactive inactive active inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active active inactive inactive inactive active active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Mi Huaiyu SRI International Cytosol ER Long Name: GTP Synonym: Synonym not specified Accession: S01705 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01702 inside SIMPLE_MOLECULE GDP Long Name: Regulator of G-protein signaling Synonym: RGS Accession: P00731 inside PROTEIN p11 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05253 Heterodimer Member Info: Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727## inside COMPLEX Complex_br_(G_beta_/G_gamma_) Long Name: Activator of G-protein signaling Synonym: AGS Accession: P00739 inside PROTEIN p12 Long Name: K+ Synonym: Synonym not specified Accession: U02316 inside ION K_super_+ Long Name: P Synonym: Synonym not specified Accession: U02315 inside ION P Long Name: K+ Synonym: Synonym not specified Accession: U02316 inside ION K_super_+ Long Name: G protein-activated inward rectifying potassium channel Synonym: GIRK Accession: P00743 transmembrane PROTEIN p18 Long Name: Arrestin Synonym: Synonym not specified Accession: P00733 inside PROTEIN p7 Long Name: Clathrin Synonym: Synonym not specified Accession: P00738 innerSurface PROTEIN p8 Long Name: Ligand Synonym: Synonym not specified Accession: S01707 inside SIMPLE_MOLECULE Ligand Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05257 Heterodimer Member Info: GqPCR#PROTEIN#Gq-protein coupled receptor#P00730#GqPCR#;Ligand#SIMPLE_MOLECULE#Ligand#S01707## transmembrane COMPLEX Complex_br_(Ligand/G_sub_q_endsub_PCR) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05252 Heterodimer Member Info: GqPCR#PROTEIN#Gq-protein coupled receptor#P00730#GqPCR#;Arrestin#PROTEIN#Arrestin#P00733## transmembrane COMPLEX Complex_br_(G_sub_q_endsub_PCR/Arrestin) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05247 Heterodimer Member Info: Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727##;Goalpha#PROTEIN#Go alpha subunit#P00729## inside COMPLEX Complex_br_(G_sub_o_endsub__alpha_/G_beta_/_br_G_gamma_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05248 Heterodimer Member Info: GoPCR#PROTEIN#Go-protein coupled receptor#P00725#GoPCR#;Ligand#SIMPLE_MOLECULE#Ligand#S01707## transmembrane COMPLEX Complex_br_(G_sub_o_endsub_PCR/Ligand) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05254 Heterodimer Member Info: GoPCR#PROTEIN#Go-protein coupled receptor#P00725#GoPCR#;Arrestin#PROTEIN#Arrestin#P00733## transmembrane COMPLEX Complex_br_(G_sub_o_endsub_PCR/Arrestin) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05251 Heterodimer Member Info: GoPCR#PROTEIN#Go-protein coupled receptor#P00725#GoPCR#;Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727##;Goalpha#PROTEIN#Go alpha subunit#P00729## transmembrane COMPLEX Complex_br_(G_sub_o_endsub_PCR/G_sub_o_endsub__alpha_/_br_G_beta_/G_gamma_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05249 Heterodimer Member Info: GoPCR#PROTEIN#Go-protein coupled receptor#P00725#GoPCR#;Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727##;Goalpha#PROTEIN#Go alpha subunit#P00729##;Ligand#SIMPLE_MOLECULE#Ligand#S01707## transmembrane COMPLEX Complex_br_(Ligand/G_sub_o_endsub_PCR/_br_G_sub_o_endsub__alpha_/G_gamma_/_br_G_beta_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05255 Heterodimer Member Info: Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727##;Gqalpha#PROTEIN#Gq alpha subunit#P00732## inside COMPLEX Complex_br_(G_sub_q_endsub__alpha_/G_beta_/_br_G_gamma_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05250 Heterodimer Member Info: Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727##;GqPCR#PROTEIN#Gq-protein coupled receptor#P00730#GqPCR#;Gqalpha#PROTEIN#Gq alpha subunit#P00732##;Ligand#SIMPLE_MOLECULE#Ligand#S01707## transmembrane COMPLEX Complex_br_(G_sub_q_endsub_PCR/G_sub_q_endsub__alpha_/_br_G_beta_/G_gamma_/_br_Ligand) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05256 Heterodimer Member Info: Ggamma#PROTEIN#G protein gamma subunit#P00726##;Gbeta#PROTEIN#G protein beta subunit#P00727##;GqPCR#PROTEIN#Gq-protein coupled receptor#P00730#GqPCR#;Gqalpha#PROTEIN#Gq alpha subunit#P00732## transmembrane COMPLEX Complex_br_(G_sub_q_endsub_PCR/G_sub_q_endsub__alpha_/_br_G_beta_/G_gamma_) Long Name: Gq-protein coupled receptor Synonym: GqPCR Accession: P00730 transmembrane PROTEIN p1 Long Name: Gq alpha subunit Synonym: Synonym not specified Accession: P00732 inside PROTEIN p3 Long Name: Gq alpha subunit Synonym: Synonym not specified Accession: P00732 inside PROTEIN p3 Long Name: Gq-protein coupled receptor Synonym: GqPCR Accession: P00730 transmembrane PROTEIN p1 Long Name: Go alpha subunit Synonym: Synonym not specified Accession: P00729 inside PROTEIN p4 Long Name: Go alpha subunit Synonym: Synonym not specified Accession: P00729 inside PROTEIN p4 Long Name: Go-protein coupled receptor Synonym: GoPCR Accession: P00725 transmembrane PROTEIN p2 Long Name: Go-protein coupled receptor Synonym: GoPCR Accession: P00725 transmembrane PROTEIN p2 Long Name: G-protein receptor kinase Synonym: Synonym not specified Accession: P00741 inside PROTEIN p31 Long Name: Phospholipase C-beta Synonym: PLC beta Accession: P00744 innerSurface PROTEIN p13 Long Name: PiP2 Synonym: Synonym not specified Accession: S01704 inside SIMPLE_MOLECULE PiP2 Long Name: IP3 Synonym: Synonym not specified Accession: S01709 inside SIMPLE_MOLECULE IP3 Long Name: Rho guanine nucleotide exchange factor Synonym: Guanine nucleotide exchange factor 115-KD,p115-RhoGEF Accession: P00728 inside PROTEIN p19 Long Name: Rho effectors Synonym: Synonym not specified Accession: U02314 inside PHENOTYPE Rho_space_effectors Long Name: Ras homolog gene family member A Synonym: ARHA,Oncogen Rho H12,RhoA,RhoH12 Accession: P00740 inside PROTEIN p20 Long Name: Ras homolog gene family member A Synonym: ARHA,Oncogen Rho H12,RhoA,RhoH12 Accession: P00740 inside PROTEIN p20 Long Name: IP3-gated calcium channel Synonym: IP3 receptor,IP3R,Inositol 1,4,5-trisphosphate receptor,Inositol trisphosphate receptor Accession: P00735 transmembrane PROTEIN p32 Long Name: Ca2+ Synonym: Synonym not specified Accession: U02312 inside ION Ca_super_2+ Long Name: Ca2+ Synonym: Synonym not specified Accession: U02312 inside ION Ca_super_2+ Long Name: Protein kinase C Synonym: Synonym not specified Accession: P00745 inside PROTEIN p33 Long Name: Calcium and diacylglycerol-regulated guanine nucleotide exchange factor Synonym: RAS guanyl nucleotide-releasing protein 2,RASGRP2 Accession: P00736 inside PROTEIN p34 Long Name: DAG Synonym: Synonym not specified Accession: S01706 inside SIMPLE_MOLECULE DAG Long Name: Rap1 GTPase-activating protein 1 Synonym: RAP1GA1,Rap1GAP Accession: P00737 inside PROTEIN p35 Long Name: Ras associated protein 1 Synonym: KREV,Ras related protein 1 Accession: P00734 inside PROTEIN p36 Long Name: Ras associated protein 1 Synonym: KREV,Ras related protein 1 Accession: P00734 inside PROTEIN p36 Long Name: Calcium ion channel Synonym: Synonym not specified Accession: P00742 transmembrane PROTEIN p37 Long Name: Ca2+ Synonym: Synonym not specified Accession: U02312 inside ION Ca_super_2+ Long Name: Receptor endocytosis Synonym: Synonym not specified Accession: U02313 inside PHENOTYPE GPCR_space_endocytosis Long Name: ATP Synonym: Synonym not specified Accession: S01703 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01708 inside SIMPLE_MOLECULE ADP STATE_TRANSITION 0.4636072970678191,3.548344639638934E-4 0.6962109678072201,-6.672362901720685E-4 a8 a13 a102 a7 a11 HETERODIMER_ASSOCIATION -0.003507228990931921,0.5596871439265435 a10 a13 a17 HETERODIMER_ASSOCIATION 0.6402772491691775,0.2253285956484028 a19 a17 a12 HETERODIMER_ASSOCIATION 0.3484529187046208,0.24761381002800764 a14 a12 a5 STATE_TRANSITION a28 a24 a8 STATE_TRANSITION 0.6852309474427827,3.059215490797129E-4 a22 a21 a24 STATE_TRANSITION a27 a26 a90 TRANSPORT 0.3660714285714288,-1.7763568394002505E-15 a30 a23 a26 STATE_TRANSITION 0.7182215782651922,5.909339775835853E-4 a6 a11 a8 STATE_TRANSITION 0.3547963485798493,-0.019645497707557746 0.5876049615300349,-0.02056963152134439 a16 a139 a15 a140 a11 DISSOCIATION 0.1900439975184245,-0.0026652353198324263 0.6153116234403888,1.9693667695697137E-4 0.8794025126558923,-0.24490099042772595 a1 a35 a33 a32 a36 a136 HETERODIMER_ASSOCIATION 0.5810231835248885,0.3277791680211575 a46 a51 a43 HETERODIMER_ASSOCIATION 0.3564123532773644,0.2386576841389907 a29 a43 a60 DISSOCIATION 0.11229309991498582,-0.010282115048350082 0.6230641141526227,-0.0029867328534403104 0.8396274732708786,-0.235320835191292 a67 a75 a69 a70 a74 a137 HETERODIMER_ASSOCIATION 0.23955673044934844,0.31353051222598216 a33 a37 a78 HETERODIMER_ASSOCIATION 0.2545574676397253,0.3039025037290628 a69 a80 a83 STATE_TRANSITION 0.3791675025479213,-0.0011212937331188666 0.7592049163027754,-0.003933799245873226 a87 a94 a97 a138 HETERODIMER_ASSOCIATION 0.465644084278787,0.5286338617860826 a94 a90 a51 a20 DISSOCIATION 0.3257530336494412,4.3626150380693396E-4 0.6775161156750205,0.006874381710852306 0.5894845680207261,0.11327081996460954 a60 a92 a67 a87 a90 a93 DISSOCIATION 0.2718978720009426,-0.005756546382654548 0.6522779743457034,0.004497664404991664 0.5360384812247707,0.11164928025990539 a5 a2 a1 a8 a10 a4 STATE_TRANSITION a142 a145 a21 TRANSPORT 0.4001823737381769,3.6415315207705135E-14 a146 a148 a145 STATE_TRANSITION a149 a152 a148 a153 STATE_TRANSITION a150 a151 a148 a153 STATE_TRANSITION 0.3393753745754773,-0.004102017713254469 0.6167942997935629,-0.003356196310839721 a155 a158 a157 a159 a151 STATE_TRANSITION 0.35409202903376613,0.0017580075913947724 0.6971965106212994,-0.002157554771253345 a157 a155 a160 a156 STATE_TRANSITION a156 a154 a90 TRANSPORT 0.2989771096309859,-2.1137589790498623E-4 a163 a164 a162 STATE_TRANSITION a162 a161 a90 MODULATION a15 a141 TRIGGER a78 a41 MODULATION a42 a41 TRIGGER a83 a84 MODULATION a81 a84