Panther Pathway: P00034 The integrin signalling pathway is triggered when integrins in the cell membrane bind to extracellular matrix components. Downstream events include actin reorganization and activation of MAPK and other signalling cascades. Medline=10446041 Medline=11017872 Medline=11707510 Medline=11807174 Medline=12640026 Medline=12743027 PMID: 10446041 PMID: 11017872 PMID: 11707510 PMID: 11807174 PMID: 12640026 PMID: 12743027 4.0 s3 PROTEIN p15 s3 PROTEIN p14 s3 PROTEIN p15 s3 PROTEIN p14 s3 PROTEIN p13 s3 PROTEIN p12 s3 PROTEIN p11 s48 PROTEIN p11 s48 PROTEIN p12 s48 PROTEIN p13 s6 PROTEIN p15 s6 PROTEIN p14 s188 PROTEIN p24 s188 PROTEIN p25 s188 PROTEIN p21 s204 PROTEIN p30 s204 PROTEIN p31 s204 PROTEIN p23 s214 PROTEIN p38 s214 PROTEIN p19 s215 PROTEIN p19 s215 PROTEIN p30 s218 PROTEIN p19 s218 PROTEIN p39 s246 PROTEIN p14 s246 PROTEIN p19 s246 PROTEIN p15 s246 PROTEIN p16 s246 PROTEIN p20 s246 PROTEIN p41 s246 PROTEIN p14 s246 PROTEIN p17 s246 PROTEIN p41 s246 PROTEIN p15 s246 PROTEIN p18 s246 PROTEIN p13 s246 PROTEIN p12 s246 PROTEIN p11 s262 PROTEIN p20 s262 PROTEIN p41 s263 PROTEIN p17 s263 PROTEIN p41 s303 PROTEIN p15 s303 PROTEIN p14 s303 PROTEIN p42 s303 PROTEIN p14 s303 PROTEIN p15 s303 PROTEIN p13 s303 PROTEIN p12 s303 PROTEIN p11 s308 SIMPLE_MOLECULE PIP2 s308 PROTEIN p20 s337 PROTEIN p50 s337 PROTEIN p51 s337 PROTEIN p52 s353 PROTEIN p15 s353 PROTEIN p14 s353 PROTEIN p19 s353 PROTEIN p21 s353 PROTEIN p16 s353 PROTEIN p20 s353 PROTEIN p41 s353 PROTEIN p14 s353 PROTEIN p17 s353 PROTEIN p41 s353 PROTEIN p15 s353 PROTEIN p18 s353 PROTEIN p13 s353 PROTEIN p12 s353 PROTEIN p11 s359 PROTEIN p23 s359 PROTEIN p30 s359 PROTEIN p32 s359 PROTEIN p53 s361 PROTEIN p54 s361 PROTEIN p19 s305 PROTEIN p25 s305 PROTEIN p24 s305 PROTEIN p44 s368 PROTEIN p20 s368 SIMPLE_MOLECULE PIP2 s368 PROTEIN p45 s372 PROTEIN p20 s372 SIMPLE_MOLECULE PIP2 s372 PROTEIN p46 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05343 Heterodimer Member Info: PINCH#PROTEIN#PINCH#P00921##;ILK#PROTEIN#Integrin linked kinase#P00935#ILK|Integrin linked kinase#;Parvin#PROTEIN#Parvin#P00945#ILK binding protein|ILKBP|Integrin linked kinase binding protein|Parvin# s353 COMPLEX Complex_br_(ILK/PINCH/_br_Parvin) s373 PROTEIN p50 s373 PROTEIN p51 s373 PROTEIN p52 Long Name: Fyn Synonym: Synonym not specified Accession: P00942 s303 PROTEIN p43 SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active active active active active active active active active active active active active active active active active active active inactive active active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active active active active inactive inactive inactive inactive inactive inactive inactive active active inactive active active inactive inactive inactive inactive inactive inactive inactive active active active inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive active Iwasa Janet SRI International cytoplasm Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05338 Heterodimer Member Info: Collagen#PROTEIN#Collagen#P00922##;Integrin beta#PROTEIN#Integrin beta#P00931##;Fibronectin#PROTEIN#Fibronectin#P00939##;Integrin alpha#PROTEIN#Integrin alpha#P00941##;Laminin#PROTEIN#Laminin#P00947## transmembrane COMPLEX Complex_br_(Integrin_br__beta_/Integrin_br__alpha/_br_Integrin_br__beta_/Integrin_br__alpha/_br_Collagen/Laminin/_br_Fibronectin) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05340 Heterodimer Member Info: Collagen#PROTEIN#Collagen#P00922##;Fibronectin#PROTEIN#Fibronectin#P00939##;Laminin#PROTEIN#Laminin#P00947## inside COMPLEX Complex_br_(Fibronectin/Laminin/_br_Collagen) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05334 Heterodimer Member Info: Integrin beta#PROTEIN#Integrin beta#P00931##;Integrin alpha#PROTEIN#Integrin alpha#P00941## transmembrane COMPLEX Complex_br_(Integrin_br__beta_/Integrin_br__alpha) Long Name: Talin Synonym: Synonym not specified Accession: P00943 inside PROTEIN p16 Long Name: Focal Adhesion Kinase Synonym: FAK,Focal adhesion kinase Accession: P00932 inside PROTEIN p21 Long Name: Focal Adhesion Kinase Synonym: FAK,Focal adhesion kinase Accession: P00932 inside PROTEIN p21 Long Name: Src Synonym: Synonym not specified Accession: P00940 inside PROTEIN p22 Long Name: Focal Adhesion Kinase Synonym: FAK,Focal adhesion kinase Accession: P00932 inside PROTEIN p21 Long Name: Growth factor receptor bound protein 2 Synonym: Growth factor receptor bound protein 2,grb2 Accession: P00910 inside PROTEIN p24 Long Name: Son of sevenless Synonym: SOS,Son of sevenless Accession: P00920 inside PROTEIN p25 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05332 Heterodimer Member Info: Grb2#PROTEIN#Growth factor receptor bound protein 2#P00910#Growth factor receptor bound protein 2|grb2#;SOS#PROTEIN#Son of sevenless#P00920#SOS|Son of sevenless#;FAK#PROTEIN#Focal Adhesion Kinase#P00932#FAK|Focal adhesion kinase# inside COMPLEX Complex_br_(Grb2/SOS/_br_FAK) Long Name: Ras Synonym: Synonym not specified Accession: P00916 inside PROTEIN p26 Long Name: Raf Synonym: Synonym not specified Accession: P00924 inside PROTEIN p27 Long Name: Mitogen activated protein kinase kinase Synonym: MAP kinase kinase,MAP/ERK kinase,MAPKK Accession: P00925 inside PROTEIN p28 Long Name: Extracellular signal-regulated kinase Synonym: Erk,Extracellular signal-regulated kinase Accession: P00907 inside PROTEIN p29 Long Name: p130 Crk-associated substrate Synonym: CAS,p130 Crk-associated substrate,p130CAS Accession: P00908 inside PROTEIN p23 Long Name: p130 Crk-associated substrate Synonym: CAS,p130 Crk-associated substrate,p130CAS Accession: P00908 inside PROTEIN p23 Long Name: CRK SH3 domain-binding guanine nucleotide-releasing factor Synonym: C3G,CRK SH3 domain-binding guanine nucleotide-releasing factor Accession: P00929 inside PROTEIN p31 Long Name: Crk Synonym: Synonym not specified Accession: P00933 inside PROTEIN p30 Long Name: Dock180 Synonym: Synonym not specified Accession: P00930 inside PROTEIN p32 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05341 Heterodimer Member Info: p130CAS#PROTEIN#p130 Crk-associated substrate#P00908#CAS|p130 Crk-associated substrate|p130CAS#;C3G#PROTEIN#CRK SH3 domain-binding guanine nucleotide-releasing factor#P00929#C3G|CRK SH3 domain-binding guanine nucleotide-releasing factor#;Crk#PROTEIN#Crk#P00933## inside COMPLEX Complex_br_(Crk/C3G/_br_p130CAS) Long Name: Rac Synonym: Synonym not specified Accession: P00927 inside PROTEIN p33 Long Name: C-Jun N-terminal kinase Synonym: C-Jun N-terminal kinase,Jnk Accession: P00951 inside PROTEIN p34 Long Name: Rap1 Synonym: Synonym not specified Accession: P00906 inside PROTEIN p35 Long Name: B-Raf Synonym: Synonym not specified Accession: P00911 inside PROTEIN p36 Long Name: Phosphatidylinositol-3-kinase Synonym: PI3-K Accession: P00936 inside PROTEIN p37 Long Name: Phosphatidylinositol-3-kinase Synonym: PI3-K Accession: P00936 inside PROTEIN p37 Long Name: Phosphoinositide bisphosphate, PIP2 Synonym: Synonym not specified Accession: S01740 inside SIMPLE_MOLECULE PIP2 Long Name: Paxillin Synonym: Synonym not specified Accession: P00950 inside PROTEIN p19 Long Name: Paxillin Synonym: Synonym not specified Accession: P00950 inside PROTEIN p19 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05336 Heterodimer Member Info: Csk#PROTEIN#C-terminal Src kinase#P00913#C-terminal Src kinase|Csk#;Paxillin#PROTEIN#Paxillin#P00950## inside COMPLEX Complex_br_(Csk/Paxillin) Long Name: C-terminal Src kinase Synonym: C-terminal Src kinase,Csk Accession: P00913 inside PROTEIN p38 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05330 Heterodimer Member Info: Crk#PROTEIN#Crk#P00933##;Paxillin#PROTEIN#Paxillin#P00950## inside COMPLEX Complex_br_(Paxillin/Crk) Long Name: Protein tyrosine phosphatase-PEST Synonym: PTP-PEST,Protein tyrosin phosphatase-PEST Accession: P00915 inside PROTEIN p39 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05347 Heterodimer Member Info: PTP-PEST#PROTEIN#Protein tyrosine phosphatase-PEST#P00915#PTP-PEST|Protein tyrosin phosphatase-PEST#;Paxillin#PROTEIN#Paxillin#P00950## inside COMPLEX Complex_br_(Paxillin/PTP-PEST) Long Name: Filamin Synonym: Synonym not specified Accession: P00914 inside PROTEIN p18 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05342 Heterodimer Member Info: Filamin#PROTEIN#Filamin#P00914##;Collagen#PROTEIN#Collagen#P00922##;alpha actinin#PROTEIN#alpha actinin#P00928##;Integrin beta#PROTEIN#Integrin beta#P00931##;Vinculin#PROTEIN#Vinculin#P00937##;Fibronectin#PROTEIN#Fibronectin#P00939##;Integrin alpha#PROTEIN#Integrin alpha#P00941##;Talin#PROTEIN#Talin#P00943##;Actin#PROTEIN#Actin#P00944##;Laminin#PROTEIN#Laminin#P00947##;Paxillin#PROTEIN#Paxillin#P00950## transmembrane COMPLEX Complex_br_(Integrin_br__alpha/Paxillin/_br_Integrin_br__beta_/Talin/_br_Vinculin/Actin/_br_Integrin_br__alpha/_alpha__br_actinin/_br_Actin/Integrin_br__beta_/_br_Filamin/Collagen/_br_Laminin/Fibronectin) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05344 Heterodimer Member Info: Vinculin#PROTEIN#Vinculin#P00937##;Actin#PROTEIN#Actin#P00944## inside COMPLEX Complex_br_(Vinculin/Actin) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05349 Heterodimer Member Info: alpha actinin#PROTEIN#alpha actinin#P00928##;Actin#PROTEIN#Actin#P00944## inside COMPLEX Complex_br_(_alpha__br_actinin/Actin) Long Name: Caveolin Synonym: Synonym not specified Accession: P00918 transmembrane PROTEIN p42 Long Name: Fyn Synonym: Synonym not specified Accession: P00942 inside PROTEIN p43 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05346 Heterodimer Member Info: Caveolin#PROTEIN#Caveolin#P00918##;Collagen#PROTEIN#Collagen#P00922##;Integrin beta#PROTEIN#Integrin beta#P00931##;Fibronectin#PROTEIN#Fibronectin#P00939##;Integrin alpha#PROTEIN#Integrin alpha#P00941##;Laminin#PROTEIN#Laminin#P00947## transmembrane COMPLEX Complex_br_(Integrin_br__beta_/Integrin_br__alpha/_br_Caveolin/Integrin_br__alpha/_br_Integrin_br__beta_/Collagen/_br_Laminin/Fibronectin) Long Name: Vinculin Synonym: Synonym not specified Accession: P00937 inside PROTEIN p20 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05345 Heterodimer Member Info: PIP2#SIMPLE_MOLECULE#Phosphoinositide bisphosphate, PIP2#S01740##;Vinculin#PROTEIN#Vinculin#P00937## inside COMPLEX Complex_br_(PIP2/Vinculin) Long Name: Arp2/3 Synonym: Actin related protein complex 2/3 Accession: P00912 inside PROTEIN p45 Long Name: Vasodilator-stimulated phosphoprotein Synonym: VASP,Vasodilator-stimulated phosphoprotein Accession: P00934 inside PROTEIN p46 Long Name: Actin polymerization Synonym: Synonym not specified Accession: U02416 inside PHENOTYPE Actin_br_polymerization Long Name: ? Synonym: Synonym not specified Accession: U02414 inside UNKNOWN ? Long Name: Rho Synonym: Synonym not specified Accession: P00948 inside PROTEIN p47 Long Name: Cell division cycle 42 Synonym: Cdc42,Cell division cycle 42 Accession: P00938 inside PROTEIN p49 Long Name: Actin stress fibers Synonym: Synonym not specified Accession: U02415 inside PHENOTYPE Actin_br_stress_space_fibers Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05343 Heterodimer Member Info: PINCH#PROTEIN#PINCH#P00921##;ILK#PROTEIN#Integrin linked kinase#P00935#ILK|Integrin linked kinase#;Parvin#PROTEIN#Parvin#P00945#ILK binding protein|ILKBP|Integrin linked kinase binding protein|Parvin# inside COMPLEX Complex_br_(ILK/PINCH/_br_Parvin) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05333 Heterodimer Member Info: Filamin#PROTEIN#Filamin#P00914##;Collagen#PROTEIN#Collagen#P00922##;alpha actinin#PROTEIN#alpha actinin#P00928##;Integrin beta#PROTEIN#Integrin beta#P00931##;FAK#PROTEIN#Focal Adhesion Kinase#P00932#FAK|Focal adhesion kinase#;Vinculin#PROTEIN#Vinculin#P00937##;Fibronectin#PROTEIN#Fibronectin#P00939##;Integrin alpha#PROTEIN#Integrin alpha#P00941##;Talin#PROTEIN#Talin#P00943##;Actin#PROTEIN#Actin#P00944##;Laminin#PROTEIN#Laminin#P00947##;Paxillin#PROTEIN#Paxillin#P00950## transmembrane COMPLEX Complex_br_(Integrin_br__beta_/Integrin_br__alpha/_br_Paxillin/FAK/_br_Talin/Vinculin/_br_Actin/Integrin_br__alpha/_br__alpha__br_actinin/Actin/_br_Integrin_br__beta_/Filamin/_br_Collagen/Laminin/_br_Fibronectin) Long Name: ELMO Synonym: Synonym not specified Accession: P00917 inside PROTEIN p53 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05337 Heterodimer Member Info: p130CAS#PROTEIN#p130 Crk-associated substrate#P00908#CAS|p130 Crk-associated substrate|p130CAS#;ELMO#PROTEIN#ELMO#P00917##;Dock180#PROTEIN#Dock180#P00930##;Crk#PROTEIN#Crk#P00933## inside COMPLEX Complex_br_(p130CAS/Crk/_br_Dock180/ELMO) Long Name: Abelson protein kinase Synonym: c-Abl Accession: P00946 inside PROTEIN p54 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05331 Heterodimer Member Info: Abl#PROTEIN#Abelson protein kinase#P00946#c-Abl#;Paxillin#PROTEIN#Paxillin#P00950## inside COMPLEX Complex_br_(Abl/Paxillin) Long Name: GTPase regulator associated with FAK Synonym: GRAF,GTPase regulator associated with FAK Accession: P00926 inside PROTEIN p55 Long Name: ASAP1 Synonym: Synonym not specified Accession: P00909 inside PROTEIN p56 Long Name: ADP ribosylation factor 1 Synonym: ARF1,Adenosine diphosphate ribosylation factor 1 Accession: P00923 inside PROTEIN p58 Long Name: ADP ribosylation factor 6 Synonym: ARF6,Adenosine diphosphate ribosylation factor 6 Accession: P00919 inside PROTEIN p59 Long Name: SH2 domain containing oncogenic protein Synonym: SH2 domain containing oncogenic protein,Shc Accession: P00949 inside PROTEIN p44 Long Name: SH2 domain containing oncogenic protein Synonym: SH2 domain containing oncogenic protein,Shc Accession: P00949 inside PROTEIN p44 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05339 Heterodimer Member Info: Grb2#PROTEIN#Growth factor receptor bound protein 2#P00910#Growth factor receptor bound protein 2|grb2#;SOS#PROTEIN#Son of sevenless#P00920#SOS|Son of sevenless#;Shc#PROTEIN#SH2 domain containing oncogenic protein#P00949#SH2 domain containing oncogenic protein|Shc# inside COMPLEX Complex_br_(SOS/Grb2/_br_Shc) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05335 Heterodimer Member Info: Arp2/3#PROTEIN#Arp2/3#P00912#Actin related protein complex 2/3#;PIP2#SIMPLE_MOLECULE#Phosphoinositide bisphosphate, PIP2#S01740##;Vinculin#PROTEIN#Vinculin#P00937## inside COMPLEX Complex_br_(Vinculin/PIP2/_br_Arp2/3) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05348 Heterodimer Member Info: VASP#PROTEIN#Vasodilator-stimulated phosphoprotein#P00934#VASP|Vasodilator-stimulated phosphoprotein#;PIP2#SIMPLE_MOLECULE#Phosphoinositide bisphosphate, PIP2#S01740##;Vinculin#PROTEIN#Vinculin#P00937## inside COMPLEX Complex_br_(Vinculin/PIP2/_br_VASP) STATE_TRANSITION a172 a240 a241 STATE_TRANSITION a244 a245 a172 HETERODIMER_ASSOCIATION 0.13492490753948694,0.003354440185454166 0.0044002761567440984,0.4552625129298242 a240 a250 a251 a255 HETERODIMER_ASSOCIATION 0.19918449227828638,-0.0011916953137323105 0.053914164890283445,0.45035705677787785 a245 a277 a278 a282 STATE_TRANSITION a295 a296 a172 STATE_TRANSITION a297 a299 a172 STATE_TRANSITION a299 a300 HETERODIMER_ASSOCIATION -0.1320980651666943,0.5431398500031435 a296 a302 a309 HETERODIMER_ASSOCIATION 5.905238293779647E-4,0.47335695428650837 a296 a301 a310 HETERODIMER_ASSOCIATION 0.017256486712696528,0.32452526679221805 a296 a312 a315 STATE_TRANSITION a316 a317 a315 HETERODIMER_ASSOCIATION 0.2009806141496151,0.38282580747635553 a5 a132 a131 a393 a394 a128 a361 HETERODIMER_ASSOCIATION 0.20918861085292484,-0.0017208827238466284 -0.09377859685955209,0.4901716251233319 a7 a6 a8 a5 HETERODIMER_ASSOCIATION 0.23143135581561225,0.0037185468788658582 -0.0665886496937107,0.4438791962235449 a7 a397 a398 a396 STATE_TRANSITION 0.43994183830717976,-0.005242837495236685 a420 a421 a444 HETERODIMER_ASSOCIATION 0.02773568443770813,0.43754609918590903 a396 a402 a444 HETERODIMER_ASSOCIATION 0.4058441558441539,0.22400982102475098 a460 a300 a466 STATE_TRANSITION a546 a172 a242 HETERODIMER_ASSOCIATION 0.1130812471863969,0.004344338687078064 -0.0033075018204833384,0.5141114832455309 a361 a557 a146 a546 HETERODIMER_ASSOCIATION 0.21463900470068653,-0.013485929095708116 0.01568344811402511,0.4637011344659161 a245 a275 a276 a558 a565 HETERODIMER_ASSOCIATION 0.016260162601632544,0.47967479674796554 a296 a566 a569 HETERODIMER_ASSOCIATION 0.13308361091081533,-0.010116509171303356 -0.005283853722883425,0.3832438080694085 a421 a447 a446 a452 STATE_TRANSITION 0.5107411287584842,-0.004289759211330679 a403 a444 a444 STATE_TRANSITION a453 a576 a452 STATE_TRANSITION a454 a579 a576 STATE_TRANSITION a455 a580 a579 STATE_TRANSITION a456 a581 a580 STATE_TRANSITION a473 a583 a471 STATE_TRANSITION a477 a585 a471 STATE_TRANSITION a474 a586 a471 STATE_TRANSITION a283 a587 a565 STATE_TRANSITION a284 a588 a587 STATE_TRANSITION a285 a589 a282 STATE_TRANSITION a286 a590 a589 STATE_TRANSITION a289 a591 a590 STATE_TRANSITION a290 a592 a591 STATE_TRANSITION a256 a593 a255 STATE_TRANSITION a257 a594 a593 STATE_TRANSITION a258 a595 a594 STATE_TRANSITION a259 a596 a595 STATE_TRANSITION a570 a601 a172 STATE_TRANSITION a575 a602 a601 STATE_TRANSITION a571 a604 a172 STATE_TRANSITION a573 a605 a604 STATE_TRANSITION a574 a606 a604 HETERODIMER_ASSOCIATION -0.026857967717948128,0.3625825641922926 a467 a466 a617 HETERODIMER_ASSOCIATION 0.633880794785961,0.353095201866509 a466 a608 a621 STATE_TRANSITION a470 a471 a396 MODULATION a583 a476 MODULATION a585 a476 MODULATION a586 a478 STATE_TRANSITION a318 sa190 a309 MODULATION a617 a469 MODULATION a621 a469