Panther Pathway: P00035 The interferon-gamma signaling pathway modulates the antiproliferative and antiviral properties of interferon-gamma. Signal transduction from the membrane to the nucleus is rapid and direct. The main signaling pathway involves the activation of STAT1 by the Jak family of tyrosine kinases at the cell membrane, followed by release, dimerization, and translocation of STAT1 to the nucleus, where they transcriptional induce expression of many gene products. Medline=11929133 Medline=14525967 PMID: 11929133 PMID: 14525967 4.0 s75 PROTEIN p5 s75 PROTEIN p6 s75 PROTEIN p11 s81 PROTEIN p5 s81 PROTEIN p6 s81 PROTEIN p11 s81 PROTEIN p4 s81 PROTEIN p2 s81 PROTEIN p3 s94 PROTEIN p5 s94 PROTEIN p6 s94 PROTEIN p11 s94 PROTEIN p2 s94 PROTEIN p3 SQUARE_CLOSEUP_NORTHWEST SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active inactive inactive inactive active active inactive inactive inactive active active Su Leon SRI International nucleus Membrane Long Name: Janus kinase 2 Synonym: Jak2 Accession: P00952 inside PROTEIN p3 Long Name: Janus kinase 1 Synonym: Jak1 Accession: P00953 inside PROTEIN p2 Long Name: antiviral genes include dsRNA-dependent protein kinase (PKR), 2-5A synthetase, and Mx protein family Synonym: Synonym not specified Accession: U02420 inside PHENOTYPE Gene transcription Long Name: IFNGR2 Synonym: Synonym not specified Accession: P00957 transmembrane PROTEIN p6 Long Name: IFNGR1 Synonym: Synonym not specified Accession: P00959 transmembrane PROTEIN p5 Long Name: Suppressor of cytokine signaling Synonym: CIS,SOCS Accession: P00956 inside PROTEIN p7 Long Name: protein tyrosine phosphatase Synonym: PTP Accession: P00960 inside PROTEIN p8 Long Name: Serine kinase Synonym: Synonym not specified Accession: P00955 inside PROTEIN p9 Long Name: Protein inhibitors of activated STATs Synonym: PIAS Accession: P00958 inside PROTEIN p10 Long Name: ATP Synonym: Synonym not specified Accession: S01741 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01744 inside SIMPLE_MOLECULE ADP Long Name: Pi Synonym: Synonym not specified Accession: S01743 inside SIMPLE_MOLECULE Pi Long Name: Pi Synonym: Synonym not specified Accession: S01743 inside SIMPLE_MOLECULE Pi Long Name: Signal transducers and activaotrs of transcription 1 Synonym: STAT1 Accession: P00961 inside PROTEIN p4 Long Name: Signal transducers and activaotrs of transcription 1 Synonym: STAT1 Accession: P00961 inside PROTEIN p4 Long Name: Signal transducers and activaotrs of transcription 1 Synonym: STAT1 Accession: P00961 inside PROTEIN p4 2 Long Name: Signal transducers and activaotrs of transcription 1 Synonym: STAT1 Accession: P00961 inside PROTEIN p4 2 Long Name: 2 ATP Synonym: Synonym not specified Accession: S01745 inside SIMPLE_MOLECULE 2 ATP Long Name: 2 ADP Synonym: Synonym not specified Accession: S01742 inside SIMPLE_MOLECULE 2 ADP Long Name: Janus kinase 1 Synonym: Jak1 Accession: P00953 inside PROTEIN p2 Long Name: Janus kinase 2 Synonym: Jak2 Accession: P00952 inside PROTEIN p3 Long Name: protein tyrosine phosphatase Synonym: PTP Accession: P00960 inside PROTEIN p8 Long Name: Interferongamma Synonym: Synonym not specified Accession: P00954 inside PROTEIN p11 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05351 Heterodimer Member Info: Interferongamma#PROTEIN#Interferongamma#P00954##;IFNGR2#PROTEIN#IFNGR2#P00957##;IFNGR1#PROTEIN#IFNGR1#P00959## transmembrane COMPLEX Complex_br_(IFNGR1/IFNGR2/_br_Interferon_gamma_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05352 Heterodimer Member Info: Jak2#PROTEIN#Janus kinase 2#P00952#Jak2#;Jak1#PROTEIN#Janus kinase 1#P00953#Jak1#;Interferongamma#PROTEIN#Interferongamma#P00954##;IFNGR2#PROTEIN#IFNGR2#P00957##;IFNGR1#PROTEIN#IFNGR1#P00959##;STAT1#PROTEIN#Signal transducers and activaotrs of transcription 1#P00961#STAT1# transmembrane COMPLEX Complex_br_(IFNGR1/IFNGR2/_br_Interferon_gamma_/STAT1/_br_Jak1/Jak2) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05350 Heterodimer Member Info: Jak2#PROTEIN#Janus kinase 2#P00952#Jak2#;Jak1#PROTEIN#Janus kinase 1#P00953#Jak1#;Interferongamma#PROTEIN#Interferongamma#P00954##;IFNGR2#PROTEIN#IFNGR2#P00957##;IFNGR1#PROTEIN#IFNGR1#P00959## transmembrane COMPLEX Complex_br_(IFNGR1/IFNGR2/_br_Interferon_gamma_/Jak1/_br_Jak2) TRANSPORT a90 a91 STATE_TRANSITION 0.2502657326527693,5.755180870623544E-4 0.491389982510406,-0.0010359314219072768 a6 a77 a92 a78 a7 a61 STATE_TRANSITION 0.25509781341131577,7.655938887190517E-4 0.4951898730925548,0.001486152842806343 a7 a138 a93 a137 a6 a61 STATE_TRANSITION 0.142348789489398,6.394973731074227E-4 0.3010515082934744,0.001823263338504022 a92 a6 a80 a63 STATE_TRANSITION 0.1266561259225676,3.8011755051375884E-4 0.3157286229215419,9.475577268595048E-4 a93 a7 a80 a63 DISSOCIATION 0.3610440919564164,0.0035024343072995734 0.0012612514517975626,0.5619827961672481 a91 a73 a74 a87 a75 a94 HETERODIMER_ASSOCIATION -7.193142804999717,3.179241861814999 a43 a44 a105 a112 DISSOCIATION 0.17663984702031943,0.39403168674981126 a119 a90 a135 HETERODIMER_ASSOCIATION 0.3591061981984476,-0.006914209134898819 0.17599300580900118,0.3700258297563457 a112 a93 a92 a100 a136 a101 a93 a92 HETERODIMER_ASSOCIATION 0.4412659201458524,-0.012803571384023549 0.32101213091064584,0.391220224981619 a136 a28 a83 a119 a84 a65 a93 a92 PHYSICAL_STIMULATION a91 a35