Panther Pathway: P00037 Ionotropic Glutamate Receptors (iGluRs) are responsible for fast, reliable neutortansmission in the vertebrate central nervous system, i.e. they mediate signals associated with all 5 senses in brain and spinal cord, and are essential for learning and memory. Activity of iGluRs and levels of glutamate are tightly controlled by metabotropic glutamate receptors, and secondarily by other receptor types. Website=http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html Website=http://www.georgetown.edu/departments/pharmacology/sheng.pdf 4.0 Long Name: N-methyl-D-aspartate Receptor Synonym: NMDA,NMDA Receptor Accession: P01024 s218 PROTEIN p14 s99 PROTEIN p10 s99 ION Ca_super_2+ s139 PROTEIN p30 s139 PROTEIN p31 s169 PROTEIN p12 s169 SIMPLE_MOLECULE Glutamate s174 PROTEIN p17 s174 SIMPLE_MOLECULE Glutamate s185 PROTEIN p23 s185 SIMPLE_MOLECULE Glutamate s189 PROTEIN p14 s189 PROTEIN p33 s212 PROTEIN p21 s212 PROTEIN p19 s212 PROTEIN p18 s217 PROTEIN p21 s217 PROTEIN p20 s217 PROTEIN p19 Long Name: PSD95 Synonym: DLG4 Accession: P00999 s218 PROTEIN p33 Long Name: Glutamate Synonym: Synonym not specified Accession: S01752 s218 SIMPLE_MOLECULE Glutamate Long Name: Glutamate Synonym: Synonym not specified Accession: S01752 s221 SIMPLE_MOLECULE Glutamate Long Name: AMPA/Kainate Receptor Synonym: AMPA Receptor,Kainate Receptor Accession: P01025 s221 PROTEIN p15 s178 SIMPLE_MOLECULE Glutamate Long Name: excitatory amino acid transporter Synonym: EAAT1,GLAST1,GLT-1 Accession: P01011 s178 PROTEIN p16 SQUARE SQUARE_CLOSEUP_SOUTHEAST SQUARE_CLOSEUP_NORTH SQUARE SQUARE SQUARE inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Bandrowski Anita SRI International synaptic vessicle nerve terminal Neuronal Cytosol vessicle lysosome Long Name: Vesicular Glutamate Transporter Synonym: Synonym not specified Accession: P01021 transmembrane PROTEIN p17 Long Name: excitatory amino acid transporter Synonym: EAAT1,GLAST1,GLT-1 Accession: P01011 transmembrane PROTEIN p16 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05359 Heterodimer Member Info: Ca2+ channel#ION#Ca2+#U02434##;SNARE Complex#PROTEIN#N-ethylmaleimide-sensitive factor attachment protein receptor#P01013#SNARE# transmembrane COMPLEX Complex_br_(SNARE Complex/Ca_super_2+) Long Name: cAMP Synonym: Synonym not specified Accession: S01753 inside SIMPLE_MOLECULE cAMP Long Name: Metabotropic Glutamate Receptor 2, Metabotropic Glutamate Receptor 3 Synonym: GRM2,GRM3,mGlu 2,mGlu 3,mGlu2,mGlu3,mGluR2,mGluR3 Accession: P01014 transmembrane PROTEIN p12 Long Name: Glutamate Synonym: Synonym not specified Accession: S01752 inside SIMPLE_MOLECULE Glutamate Long Name: Ca2+ Synonym: Synonym not specified Accession: U02434 inside ION Ca_super_2+ Long Name: Glutamate Synonym: Synonym not specified Accession: S01752 inside SIMPLE_MOLECULE Glutamate Long Name: AMPA/Kainate Receptor Synonym: AMPA Receptor,Kainate Receptor Accession: P01025 transmembrane PROTEIN p15 Long Name: K+ Synonym: Synonym not specified Accession: U02435 inside ION K_super_+ Long Name: Na+ Synonym: Synonym not specified Accession: U02438 inside ION Na_super_+ Long Name: K+ Synonym: Synonym not specified Accession: U02435 inside ION K_super_+ Long Name: Ca2+ Synonym: Synonym not specified Accession: U02434 inside ION Ca_super_2+ Long Name: Glutamate receptor, ionotropic, AMPA 1 Synonym: AMPA,AMPA R,GRIA1,glu1,glur1 Accession: P01018 transmembrane PROTEIN p18 Long Name: Glutamate receptor, ionotropic, AMPA 2 Synonym: AMPA,AMPA R,GRIA2,glu2,glur2 Accession: P01017 transmembrane PROTEIN p19 Long Name: Glutamate receptor, ionotropic, AMPA 3 Synonym: AMPA,AMPA R,GRIA2,glu3,glur3 Accession: P01016 transmembrane PROTEIN p20 Long Name: Glutamate receptor, ionotropic, AMPA 4 Synonym: AMPA,AMPA R,GRIA4,glu4,glur4 Accession: P01015 transmembrane PROTEIN p21 Long Name: Kainate Receptor Synonym: Synonym not specified Accession: P01026 transmembrane PROTEIN p23 Long Name: glutamate receptor, ionotropic, kainate 1 Synonym: EAA3,EEA3,GLR5,GLUR5,GRIK1 Accession: P01004 transmembrane PROTEIN p24 Long Name: Glutamate receptor, ionotropic kainate 2 Synonym: EAA4,Excitatory amino acid receptor 4,GRIK2,GluR-6,GluR6,Glutamate receptor 6 Accession: P01003 transmembrane PROTEIN p25 Long Name: glutamate receptor, ionotropic, kainate 3 Synonym: EAA5,GLR7,GLUR7,GRIK3,excitatory amino acid receptor 5 Accession: P01002 transmembrane PROTEIN p26 Long Name: glutamate receptor, ionotropic, kainate 4 Synonym: EAA4,GRIK4,excitatory amino acid receptor 4 Accession: P01001 transmembrane PROTEIN p27 Long Name: Kainate Receptor Synonym: Synonym not specified Accession: P01026 transmembrane PROTEIN p23 Long Name: N-Ethylmaleimide-sensitive fusion protein Synonym: Synonym not specified Accession: P01020 inside PROTEIN p29 Long Name: AMPA Receptor Synonym: AMPA Receptor Accession: P01019 transmembrane PROTEIN p22 Long Name: Glutamate receptor, ionotropic kainate 5 Synonym: EAA2,Excitatory amino acid receptor 2 Accession: P01000 transmembrane PROTEIN p28 Long Name: stargazin Synonym: TARP Accession: P00998 inside PROTEIN p32 Long Name: Long Name: PICK1, CaMKII, GRIP1, CaMKIINalpha Synonym: Synonym not specified Accession: U05361 Heterodimer Member Info: PICK#PROTEIN#protein that interacts with C kinase 1#P01012#GRIP1#;CaMKII#PROTEIN#calcium/calmodulin-dependent protein kinase II#P01023#CaMKIINalpha|GRIP1|protein that interacts with C kinase 1# inside COMPLEX Complex_br_(PICK/CaMKII) Long Name: Glutamate/NMDA receptor epsilon 1 subunit / e 1 subunit Synonym: GRIN2A,N-methyl D-aspartate receptor subtype 2A,NMDAR2A Accession: P01008 transmembrane PROTEIN p35 Long Name: N-methyl-D-aspartate Receptor Synonym: NMDA,NMDA Receptor Accession: P01024 transmembrane PROTEIN p14 Long Name: N-methyl-D-aspartate Receptor Synonym: NMDA,NMDA Receptor Accession: P01024 inside PROTEIN p14 Long Name: AMPA Receptor Synonym: AMPA Receptor Accession: P01019 inside PROTEIN p22 Long Name: Kainate Receptor Synonym: Synonym not specified Accession: P01026 inside PROTEIN p23 Long Name: a150_degraded Synonym: Synonym not specified Accession: U02436 inside DEGRADED a150_degraded Long Name: a151_degraded Synonym: Synonym not specified Accession: U02437 inside DEGRADED a151_degraded Long Name: a152_degraded Synonym: Synonym not specified Accession: U02439 inside DEGRADED a152_degraded Long Name: Glutamate/NMDA receptor zeta 1 subunit / z 1 subunit Synonym: GLURZ1,GRIN1,NR1 Accession: P01010 transmembrane PROTEIN p37 Long Name: N-methyl D-aspartate receptor subtype 2C Synonym: Glutamate [NMDA] receptor subunit epsilon 3,NMDAR2C Accession: P01006 transmembrane PROTEIN p34 Long Name: Glutamate/NMDA receptor epsilon 4 subunit / e 4 subunit Synonym: Glutamate/NMDA receptor epsilon 4 subunit / e 4 subunit Accession: P01005 transmembrane PROTEIN p36 Long Name: Glutamate/NMDA receptor epsilon 2 subunit / e 2 subunit Synonym: Glutamate/NMDA receptor epsilon 2 subunit / e 2 subunit Accession: P01007 transmembrane PROTEIN p38 Long Name: NR3 Synonym: NMDAR-L Accession: P01009 transmembrane PROTEIN p39 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05357 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01752##;mGluR 2/3#PROTEIN#Metabotropic Glutamate Receptor 2, Metabotropic Glutamate Receptor 3#P01014#GRM2|GRM3|mGlu 2|mGlu 3|mGlu2|mGlu3|mGluR2|mGluR3# transmembrane COMPLEX Complex_br_(mGluR 2/3/_br_Glutamate) Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P01013 transmembrane PROTEIN p10 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05355 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01752##;Vglut#PROTEIN#Vesicular Glutamate Transporter#P01021## transmembrane COMPLEX Complex_br_(Vglut/Glutamate) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05356 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01752##;EAAT#PROTEIN#excitatory amino acid transporter#P01011#EAAT1|GLAST1|GLT-1# transmembrane COMPLEX Complex_br_(EAAT/Glutamate) Long Name: Glutamate Synonym: Synonym not specified Accession: S01752 inside SIMPLE_MOLECULE Glutamate Long Name: Ca2+ Synonym: Synonym not specified Accession: U02434 inside ION Ca_super_2+ Long Name: Na+ Synonym: Synonym not specified Accession: U02438 inside ION Na_super_+ Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05363 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01752##;KA#PROTEIN#Kainate Receptor#P01026## transmembrane COMPLEX Complex_br_(KA/Glutamate) Long Name: PSD95 Synonym: DLG4 Accession: P00999 inside PROTEIN p33 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05358 Heterodimer Member Info: PSD95#PROTEIN#PSD95#P00999#DLG4#;NMDA#PROTEIN#N-methyl-D-aspartate Receptor#P01024#NMDA|NMDA Receptor# transmembrane COMPLEX Complex_br_(NMDA/PSD95) Long Name: Long Name: AMPA Receptor Synonym: Synonym not specified Accession: U05360 Heterodimer Member Info: Glu4#PROTEIN#Glutamate receptor, ionotropic, AMPA 4#P01015#AMPA|AMPA R|GRIA4|glu4|glur4#;Glu2#PROTEIN#Glutamate receptor, ionotropic, AMPA 2#P01017#AMPA|AMPA R|GRIA2|glu2|glur2#;Glu1#PROTEIN#Glutamate receptor, ionotropic, AMPA 1#P01018#AMPA|AMPA R|GRIA1|glu1|glur1# transmembrane COMPLEX Complex_br_(Glu4/Glu2/_br_Glu1) Long Name: Long Name: AMPA Receptor Synonym: Synonym not specified Accession: U05362 Heterodimer Member Info: Glu4#PROTEIN#Glutamate receptor, ionotropic, AMPA 4#P01015#AMPA|AMPA R|GRIA4|glu4|glur4#;Glu3#PROTEIN#Glutamate receptor, ionotropic, AMPA 3#P01016#AMPA|AMPA R|GRIA2|glu3|glur3#;Glu2#PROTEIN#Glutamate receptor, ionotropic, AMPA 2#P01017#AMPA|AMPA R|GRIA2|glu2|glur2# transmembrane COMPLEX Complex_br_(Glu4/Glu3/_br_Glu2) Long Name: Calcium Channel Synonym: Ca++ Channel,Ca2+ channel Accession: P01022 transmembrane PROTEIN p7 transmembrane COMPLEX s218 transmembrane COMPLEX s221 inside UNKNOWN ? inside SIMPLE_MOLECULE ATP TRANSPORT a64 a65 a87 STATE_TRANSITION a61 a87 a100 TRANSPORT 0.44413407821229045,-4.440892098500626E-16 a72 a4 a99 TRANSPORT 0.2805755395683467,-1.7763568394002505E-15 a119 a120 csa11 csa10 TRANSPORT 0.9149305935194336,0.0043879817070129334 a117 a116 csa11 csa10 ? TRANSPORT a126 a94 sa98 HETERODIMER_ASSOCIATION -5.169588934346407,0.961523475550365 a144 a143 a148 HETERODIMER_ASSOCIATION 0.6505051695189792,4.2416566027014824E-4 -2.4937432259336134,0.855946398659972 a146 a145 a148 TRANSPORT a126 a152 TRANSPORT a148 a150 STATE_TRANSITION a150 a157 STATE_TRANSITION a151 a159 STATE_TRANSITION a152 a160 HETERODIMER_ASSOCIATION 7.888888888888914,1.1111111111111054 a142 a161 a148 HETERODIMER_ASSOCIATION 0.014176401519633064,-0.1130974261436194 -0.4405217458501447,1.2191205830985403 a4 a91 a167 HETERODIMER_ASSOCIATION 0.002286389143104195,0.34406376017638207 a169 a65 a99 HETERODIMER_ASSOCIATION 0.19979498253961658,-0.0030837483562873302 0.11753222119689877,0.30968659742928384 a171 a97 a173 DISSOCIATION 0.08050161063807248,0.03176222603055123 0.5102646408475282,0.21585337499825297 a173 a171 a72 HETERODIMER_ASSOCIATION 0.09588817275079564,0.2944833644189907 0.21434225046067157,-0.11330974013724493 a96 a4 a176 DISSOCIATION 0.19827001039456693,0.42840734005095915 a176 a97 a96 HETERODIMER_ASSOCIATION 0.0034482758620688614,-0.05862068965517331 0.047567960540944476,0.21285029873345185 0.5,0.0 0.5,0.0 0.06420922633370463,0.4903069218378846 a133 a4 a180 TRANSPORT 0.5214014067475827,0.001965331888472477 a113 a114 csa11 csa10 TRANSPORT a148 a185 a186 HETERODIMER_ASSOCIATION 0.2964781698849013,0.0019261866260809057 2.968400686128655,1.0042598509052172 a128 a127 a129 a130 a132 a126 TRANSPORT a209 a136 a139 TRANSPORT a214 a94 a135 TRANSPORT a136 a94 a140 TRANSPORT a214 a151 TRANSPORT a209 a151 HETERODIMER_ASSOCIATION 0.15408845837309215,-0.013341497792920265 -0.012447889979060989,0.466766616691654 a122 a124 a121 a209 HETERODIMER_ASSOCIATION 0.1345816926431418,9.56220635434768E-4 0.6006569148923528,0.40947352738514375 a196 a123 a197 a214 HETERODIMER_ASSOCIATION 0.015676092817760168,0.11835280054087549 1.1993537031822044,-0.40458896554962465 a4 a186 csa10 HETERODIMER_ASSOCIATION 0.38660660182711193,0.429182871857098 a4 a94 csa11 STATE_TRANSITION sa99 a100 a167