Panther Pathway: P00038 The Jak-STAT pathway is activated by both cytokines and interferons. This pathways allows for rapid and direct transduction of an extracellular signal into the nucleus. Signal transducers and activators of transcription (STAT) are activated by the Janus (JAK) family of tyrosine kinases. Activated STATs then dimerize, translocate to the nucleus, and mediate expression of many various gene products. 4.0 s75 PROTEIN p11 s77 PROTEIN p5 s77 PROTEIN p11 s77 PROTEIN p2 s81 PROTEIN p5 s81 PROTEIN p11 s81 PROTEIN p4 s81 PROTEIN p2 s75 PROTEIN p5 SQUARE_CLOSEUP_NORTHWEST SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive active inactive inactive active active Su Leon SRI International nucleus Cytoplasm Long Name: Gene transcription Synonym: Synonym not specified Accession: U02446 inside PHENOTYPE Gene transcription Long Name: Suppressors of cytokine signaling Synonym: CIS,JAB ,SOCS,SSI-1 Accession: P01030 inside PROTEIN p7 Long Name: protein-tyrosine phosphatase Synonym: PTP Accession: P01033 inside PROTEIN p8 Long Name: Serine kinase Synonym: Synonym not specified Accession: P01029 inside PROTEIN p9 Long Name: Protein inhibitors of activated STATs Synonym: PIAS Accession: P01031 inside PROTEIN p10 Long Name: protein-tyrosine phosphatase Synonym: PTP Accession: P01033 inside PROTEIN p8 Long Name: Cytokine Receptor Synonym: Synonym not specified Accession: P01028 transmembrane PROTEIN p5 Long Name: Jak Synonym: Jak,Janus kinase,Tyk2 Accession: P01034 inside PROTEIN p2 Long Name: Jak Synonym: Jak,Janus kinase,Tyk2 Accession: P01034 inside PROTEIN p2 Long Name: Signal transducers and activators of transcription Synonym: STAT Accession: P01027 inside PROTEIN p4 Long Name: Signal transducers and activators of transcription Synonym: STAT Accession: P01027 inside PROTEIN p4 Long Name: Signal transducers and activators of transcription Synonym: STAT Accession: P01027 inside PROTEIN p4 Long Name: ADP Synonym: Synonym not specified Accession: S01757 inside SIMPLE_MOLECULE ADP Long Name: ATP Synonym: Synonym not specified Accession: S01754 inside SIMPLE_MOLECULE ATP Long Name: 2 ATP Synonym: Synonym not specified Accession: S01758 inside SIMPLE_MOLECULE 2 ATP Long Name: 2 ADP Synonym: Synonym not specified Accession: S01755 inside SIMPLE_MOLECULE 2 ADP Long Name: Cytokine Synonym: Synonym not specified Accession: P01032 inside PROTEIN p11 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05366 Heterodimer Member Info: Cytokine Receptor#PROTEIN#Cytokine Receptor#P01028##;Cytokine#PROTEIN#Cytokine#P01032## transmembrane COMPLEX Complex_br_(Cytokine Receptor/Cytokine) Long Name: Pi Synonym: Synonym not specified Accession: S01756 inside SIMPLE_MOLECULE Pi Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05365 Heterodimer Member Info: Cytokine Receptor#PROTEIN#Cytokine Receptor#P01028##;Cytokine#PROTEIN#Cytokine#P01032##;Jak#PROTEIN#Jak#P01034#Jak|Janus kinase|Tyk2# transmembrane COMPLEX Complex_br_(Cytokine Receptor/Cytokine/_br_Jak) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05364 Heterodimer Member Info: STAT#PROTEIN#Signal transducers and activators of transcription#P01027#STAT#;Cytokine Receptor#PROTEIN#Cytokine Receptor#P01028##;Cytokine#PROTEIN#Cytokine#P01032##;Jak#PROTEIN#Jak#P01034#Jak|Janus kinase|Tyk2# transmembrane COMPLEX Complex_br_(Cytokine Receptor/Cytokine/_br_STAT/Jak) Long Name: Signal transducers and activators of transcription Synonym: STAT Accession: P01027 inside PROTEIN p4 2 Long Name: Signal transducers and activators of transcription Synonym: STAT Accession: P01027 inside PROTEIN p4 2 Long Name: Pi Synonym: Synonym not specified Accession: U02445 inside ION Pi TRANSPORT a19 a27 STATE_TRANSITION 0.38028870755272803,7.75517578569529E-4 0.6572696036313148,-6.916828979404155E-4 a6 a96 a8 a95 a61 a6 STATE_TRANSITION 0.19718309859154926,-2.220446049250313E-16 0.7699530516431922,-2.220446049250313E-16 a8 a6 a97 a63 HETERODIMER_ASSOCIATION 0.4544990582328672,0.42393715189691344 a108 a43 a126 HETERODIMER_ASSOCIATION 0.2517596888460636,8.756914405215754E-4 0.5724584229241403,-0.001030954126149508 0.5794475715946592,0.24141695350290626 a8 a126 a106 a131 a107 HETERODIMER_ASSOCIATION 0.2408879865538509,0.0015438878245219723 0.46614540134009896,-7.507582404541191E-4 0.23399969685094146,0.19585036516382104 a131 a27 a100 a136 a101 a65 a131 DISSOCIATION -0.2408568224929693,0.41522930932419744 a136 a41 a131 STATE_TRANSITION a41 a137 TRANSPORT a137 a138 STATE_TRANSITION 0.6615325725620576,0.0054519744028862505 a138 a73 a102 a75 a76 PHYSICAL_STIMULATION a138 a35