Panther Pathway: P00039 Group III Metabotropic Glutamate Receptors are composed of receptor proteins, mGlu4, mGlu6, mGlu7 and mGlu8, which are negatively coupled to PKA and intracellular cAMP signalling. These receptors are found in forebrain, retina, and cerebellum. Group III mGlu receptors have not been linked with as many neurological conditions as groups I and II, however they do appear to function as strong anticonvulsants in several experimental models of epilepsy. They also seem to be neuroprotective agents in models of ischemia. Website=http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10514855 Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12575822 PMID: 10514855 PMID: 12575822 4.0 s35 PROTEIN p1 s35 SIMPLE_MOLECULE Glutamate s73 SIMPLE_MOLECULE GTP s73 PROTEIN p11 s75 PROTEIN p1 s75 PROTEIN p11 s75 SIMPLE_MOLECULE GDP s101 PROTEIN p1 s101 SIMPLE_MOLECULE Glutamate s101 PROTEIN p11 s101 SIMPLE_MOLECULE GDP s106 PROTEIN p10 s106 ION Ca_super_2+ s109 PROTEIN p16 s112 PROTEIN p17 s114 PROTEIN p16 s116 SIMPLE_MOLECULE Glutamate s120 PROTEIN p15 s120 SIMPLE_MOLECULE Glutamate s123 PROTEIN p14 s124 PROTEIN p12 s124 SIMPLE_MOLECULE Glutamate Long Name: Metabotropic Glutamate Receptor 5 Synonym: mGlu5,mGluR5 Accession: P01037 s116 PROTEIN p13 s123 SIMPLE_MOLECULE Glutamate s114 SIMPLE_MOLECULE Glutamate Long Name: Glutamate Synonym: Synonym not specified Accession: S01763 s109 SIMPLE_MOLECULE Glutamate Long Name: Glutamate Synonym: Synonym not specified Accession: S01763 s112 SIMPLE_MOLECULE Glutamate OVAL SQUARE_CLOSEUP_SOUTHEAST SQUARE_CLOSEUP_SOUTHWEST SQUARE_CLOSEUP_NORTH inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Bandrowski Anita SRI International Synaptic Vessicle Glia Neuron Nerve Terminal Long Name: Glutamate Synonym: Synonym not specified Accession: S01763 inside SIMPLE_MOLECULE Glutamate Long Name: GTP Synonym: Synonym not specified Accession: S01761 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01759 inside SIMPLE_MOLECULE GDP Long Name: cyclicAMP Synonym: Synonym not specified Accession: S01762 inside SIMPLE_MOLECULE cAMP Long Name: ATP Synonym: Synonym not specified Accession: S01760 inside SIMPLE_MOLECULE ATP Long Name: Ca2+ Synonym: Synonym not specified Accession: U02459 inside ION Ca_super_2+ Long Name: Glutamate Synonym: Synonym not specified Accession: S01763 inside SIMPLE_MOLECULE Glutamate Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P01042 transmembrane PROTEIN p10 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05369 Heterodimer Member Info: mGluR4/6/7/8#PROTEIN#mGluR4/6/7/8#P01044#GRM4|GRM6|GRM7|GRM8|mGlu 4|mGlu 6|mGlu 7|mGlu 8|mGlu4|mGlu6|mGlu7|mGlu8|mGluR4|mGluR6|mGluR7|mGluR8#;Glutamate#SIMPLE_MOLECULE#Glutamate#S01763## transmembrane COMPLEX Complex_br_(mGluR4/6/_br_7/8/_br_Glutamate) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05375 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S01761##;G-Protein#PROTEIN#Gi#P01045## inside COMPLEX Complex_br_(GTP/G-Protein) Long Name: Long Name: Metabotropic Glutamate Receptor 4, Metabotropic Glutamate Receptor 6, Metabotropic Glutamate Receptor 7, Metabotropic Glutamate Receptor 8 Synonym: Synonym not specified Accession: U05367 Heterodimer Member Info: GDP#SIMPLE_MOLECULE#GDP#S01759##;mGluR4/6/7/8#PROTEIN#mGluR4/6/7/8#P01044#GRM4|GRM6|GRM7|GRM8|mGlu 4|mGlu 6|mGlu 7|mGlu 8|mGlu4|mGlu6|mGlu7|mGlu8|mGluR4|mGluR6|mGluR7|mGluR8#;G-Protein#PROTEIN#Gi#P01045## transmembrane COMPLEX Complex_br_(mGluR4/6/_br_7/8/_br_G-Protein/GDP) Long Name: Metabotropic Glutamate Receptor 1, Metabotropic Glutamate Receptor 5 Synonym: GRM1,GRM5,mGlu1,mGlu5,mGluR1,mGluR5 Accession: P01040 transmembrane PROTEIN p12 Long Name: Metabotropic Glutamate Receptor 5 Synonym: mGlu5,mGluR5 Accession: P01037 transmembrane PROTEIN p13 Long Name: N-methyl-D-aspartate Receptor Synonym: NMDA,NMDA Receptor Accession: P01039 transmembrane PROTEIN p14 Long Name: AMPA/Kainate Receptor Synonym: A/K,AK,AMPA,AMPA Receptor,KA receptor,Kainate,Kainate Receptor Accession: P01046 transmembrane PROTEIN p15 Long Name: Calcium Channel Synonym: Ca2+ channel Accession: P01041 transmembrane PROTEIN p7 Long Name: Ca2+ Synonym: Synonym not specified Accession: U02459 inside ION Ca_super_2+ Long Name: Glutamate Synonym: Synonym not specified Accession: S01763 inside SIMPLE_MOLECULE Glutamate Long Name: Vesicular Glutamate Transporter Synonym: Vglut Accession: P01038 transmembrane PROTEIN p17 Long Name: Excitatory amino acid transporter Synonym: EAAT1,GLAST1,GLT-1 Accession: P01036 transmembrane PROTEIN p16 Long Name: Excitatory amino acid transporter Synonym: EAAT1,GLAST1,GLT-1 Accession: P01036 transmembrane PROTEIN p16 Long Name: Adenylate Cyclase Synonym: AC Accession: P01043 inside PROTEIN p5 Long Name: Protein Kinase A Synonym: PKA Accession: P01035 inside PROTEIN p6 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05374 Heterodimer Member Info: GDP#SIMPLE_MOLECULE#GDP#S01759##;mGluR4/6/7/8#PROTEIN#mGluR4/6/7/8#P01044#GRM4|GRM6|GRM7|GRM8|mGlu 4|mGlu 6|mGlu 7|mGlu 8|mGlu4|mGlu6|mGlu7|mGlu8|mGluR4|mGluR6|mGluR7|mGluR8#;Glutamate#SIMPLE_MOLECULE#Glutamate#S01763##;G-Protein#PROTEIN#Gi#P01045## transmembrane COMPLEX Complex_br_(mGluR4/6/_br_7/8/_br_Glutamate/G-Protein/_br_GDP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05377 Heterodimer Member Info: Ca2+#ION#Ca2+#U02459##;SNARE Complex#PROTEIN#N-ethylmaleimide-sensitive factor attachment protein receptor#P01042#SNARE# transmembrane COMPLEX Complex_br_(SNARE Complex/Ca_super_2+) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05368 Heterodimer Member Info: EAAT#PROTEIN#Excitatory amino acid transporter#P01036#EAAT1|GLAST1|GLT-1#;Glutamate#SIMPLE_MOLECULE#Glutamate#S01763## transmembrane COMPLEX Complex_br_(EAAT/Glutamate) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05370 Heterodimer Member Info: Vglut#PROTEIN#Vesicular Glutamate Transporter#P01038#Vglut#;Glutamate#SIMPLE_MOLECULE#Glutamate#S01763## transmembrane COMPLEX Complex_br_(Vglut/Glutamate) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05372 Heterodimer Member Info: EAAT#PROTEIN#Excitatory amino acid transporter#P01036#EAAT1|GLAST1|GLT-1#;Glutamate#SIMPLE_MOLECULE#Glutamate#S01763## transmembrane COMPLEX Complex_br_(EAAT/Glutamate) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05373 Heterodimer Member Info: mGluR 5#PROTEIN#Metabotropic Glutamate Receptor 5#P01037#mGlu5|mGluR5#;Glutamate#SIMPLE_MOLECULE#Glutamate#S01763## transmembrane COMPLEX Complex_br_(mGluR 5/Glutamate) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05378 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01763##;A/K#PROTEIN#AMPA/Kainate Receptor#P01046#A/K|AK|AMPA|AMPA Receptor|KA receptor|Kainate|Kainate Receptor# transmembrane COMPLEX Complex_br_(A/K/_br_Glutamate) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05371 Heterodimer Member Info: NMDA#PROTEIN#N-methyl-D-aspartate Receptor#P01039#NMDA|NMDA Receptor#;Glutamate#SIMPLE_MOLECULE#Glutamate#S01763## transmembrane COMPLEX Complex_br_(NMDA/Glutamate) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05376 Heterodimer Member Info: mGluR 1/5#PROTEIN#Metabotropic Glutamate Receptor 1, Metabotropic Glutamate Receptor 5#P01040#GRM1|GRM5|mGlu1|mGlu5|mGluR1|mGluR5#;Glutamate#SIMPLE_MOLECULE#Glutamate#S01763## transmembrane COMPLEX Complex_br_(mGluR 1/5/_br_Glutamate) STATE_TRANSITION a57 a56 a53 HETERODIMER_ASSOCIATION -0.3296736797268278,1.0942121729402743 a4 a85 a106 DISSOCIATION 0.3525955561168974,0.0018717425763230544 0.7011989766609137,-0.0011964886544091335 0.6619901579486398,-0.006036171758994957 a106 a19 a37 a83 a23 STATE_TRANSITION a86 a53 a83 STATE_TRANSITION a58 a89 a56 STATE_TRANSITION a61 a87 a89 TRANSPORT a64 a65 a87 HETERODIMER_ASSOCIATION 0.5717896580397639,-3.21749122196735E-4 0.5636947956376166,0.2096313296761867 a65 a107 a111 TRANSPORT 0.5560906642570207,0.0028473613389259356 a71 a4 a111 HETERODIMER_ASSOCIATION 0.31547882091584967,0.4650849726295312 a4 a112 a114 DISSOCIATION 0.5380617857939041,0.07241604297444715 a114 a112 a97 HETERODIMER_ASSOCIATION -0.30625694266429093,0.6084978210715253 a97 a98 a117 DISSOCIATION 0.060410682254364634,0.5258254830387656 a117 a71 a98 HETERODIMER_ASSOCIATION -0.10125587988420826,0.9767136251161297 a4 a95 a121 HETERODIMER_ASSOCIATION 0.14197535363981406,0.7699646482746063 a92 a4 a123 HETERODIMER_ASSOCIATION 0.5212617297528812,-0.0235594137876598 0.3589018910725734,0.5028915492034827 a4 a124 a134 HETERODIMER_ASSOCIATION 0.6091937387150921,0.27867473737590687 a4 a125 a133 HETERODIMER_ASSOCIATION 0.8279925322250032,0.06690850432181206 a4 a126 a130