Panther Pathway: P00040 Group II Metabotropic Glutamate Receptors are composed of two receptor proteins, mGlu2 and mGlu3, which are negatively coupled to PKA and intracellular cAMP signalling. These receptors are found in forebrain and cerebellum. Evidence suggests that glutamatergic neuronal transmission is involved in psychiatric and neurological disorders and that drugs that target glutamate systems may serve as novel therapeutics in humans. For example, agonists for group II mGlu receptors (mGlu2 and mGlu3) have been shown to be anxiolytic in certain animal models and have shown promise in early human trials. Lilly is developing LY-354740, the lead compound in a series of derivatives of the metabotropic glutamate receptor group II agonist L-CCG-1, for the potential treatment of anxiety. Website=http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12789623 Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14684454 PMID: 12789623 PMID: 14684454 4.0 s35 PROTEIN p1 s35 SIMPLE_MOLECULE Glutamate s69 PROTEIN p1 s69 PROTEIN p11 s69 SIMPLE_MOLECULE GDP s71 SIMPLE_MOLECULE GTP s71 PROTEIN p11 s80 PROTEIN p1 s80 SIMPLE_MOLECULE Glutamate s80 PROTEIN p11 s80 SIMPLE_MOLECULE GDP s85 PROTEIN p10 s85 ION Ca_super_2+ SQUARE_CLOSEUP_NORTHEAST OVAL OVAL active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive Bandrowski Anita SRI International nucleus Neuronal axon terminal Synaptic Vessicle Long Name: Glutamate Synonym: Synonym not specified Accession: S01764 inside SIMPLE_MOLECULE Glutamate Long Name: GTP Synonym: Synonym not specified Accession: S01767 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01768 inside SIMPLE_MOLECULE GDP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05381 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01764##;mGluR2/3#PROTEIN#Metabotropic Glutamate Receptor 2, Metabotropic Glutamate Receptor 3#P01048#GRM2|GRM3|mGlu 2|mGlu 3|mGlu2|mGlu3|mGluR2|mGluR3# transmembrane COMPLEX Complex_br_(mGluR2/3/_br_Glutamate) Long Name: cAMP Synonym: Synonym not specified Accession: S01766 inside SIMPLE_MOLECULE cAMP Long Name: ATP Synonym: Synonym not specified Accession: S01765 inside SIMPLE_MOLECULE ATP Long Name: brain-derived neurotrophic factor Synonym: Synonym not specified Accession: G01540 inside GENE gn1 Long Name: Ca2+ Synonym: Synonym not specified Accession: U02465 inside ION Ca_super_2+ Long Name: Glutamate Synonym: Synonym not specified Accession: S01764 inside SIMPLE_MOLECULE Glutamate Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P01049 transmembrane PROTEIN p10 Long Name: Long Name: Metabotropic Glutamate Receptor 2, Metabotropic Glutamate Receptor 3 Synonym: Synonym not specified Accession: U05382 Heterodimer Member Info: G-protein#PROTEIN#G-protein#P01047#Gi#;mGluR2/3#PROTEIN#Metabotropic Glutamate Receptor 2, Metabotropic Glutamate Receptor 3#P01048#GRM2|GRM3|mGlu 2|mGlu 3|mGlu2|mGlu3|mGluR2|mGluR3#;GDP#SIMPLE_MOLECULE#GDP#S01768## transmembrane COMPLEX Complex_br_(mGluR2/3/_br_G-protein/GDP) Long Name: Calcium Channel Synonym: Ca++ Channel,Ca2+ channel Accession: P01051 transmembrane PROTEIN p7 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05383 Heterodimer Member Info: G-protein#PROTEIN#G-protein#P01047#Gi#;GTP#SIMPLE_MOLECULE#GTP#S01767## inside COMPLEX Complex_br_(GTP/G-protein) Long Name: Adenylate Cyclase Synonym: AC Accession: P01052 inside PROTEIN p5 Long Name: Protein Kinase A Synonym: PKA Accession: P01050 inside PROTEIN p6 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05380 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01764##;G-protein#PROTEIN#G-protein#P01047#Gi#;mGluR2/3#PROTEIN#Metabotropic Glutamate Receptor 2, Metabotropic Glutamate Receptor 3#P01048#GRM2|GRM3|mGlu 2|mGlu 3|mGlu2|mGlu3|mGluR2|mGluR3#;GDP#SIMPLE_MOLECULE#GDP#S01768## transmembrane COMPLEX Complex_br_(mGluR2/3/_br_Glutamate/G-protein/_br_GDP) Long Name: Ca2+ Synonym: Synonym not specified Accession: U02465 inside ION Ca_super_2+ Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05379 Heterodimer Member Info: Ca2+#ION#Ca2+#U02465##;SNARE Complex#PROTEIN#N-ethylmaleimide-sensitive factor attachment protein receptor#P01049#SNARE# transmembrane COMPLEX Complex_br_(SNARE Complex/Ca_super_2+) inside RNA rn1 STATE_TRANSITION a57 a56 a81 STATE_TRANSITION a58 a82 a56 TRANSPORT 0.07566445348881143,-0.26523680706676 0.39538233443955245,-0.17403046583430148 a71 a4 a96 HETERODIMER_ASSOCIATION 0.4793081747357899,-4.884981308350689E-15 0.4212271712112532,0.2860261363909613 a4 a79 a94 DISSOCIATION 0.37047140029116044,-0.0017050903954340946 0.7109964191056317,0.0012627752141747273 0.5556595129099664,0.11861701094514654 a94 a19 a37 a84 a23 STATE_TRANSITION a53 a81 a84 STATE_TRANSITION 0.5416666666666696,0.0 a61 a83 a82 TRANSPORT 0.33954664930156153,0.002005387520912283 a64 a65 a83 HETERODIMER_ASSOCIATION 0.06067652177353278,0.4651213910243843 a95 a65 a96 TRANSCRIPTION a59 sa33 a82