Panther Pathway: P00041 Group I Metabotropic Glutamate Receptors are composed of two receptor proteins, mGlu1 and mGlu5, which are coupled to PLC and intracellular calcium signalling. These receptors are found in forebrain and cerebellum. To date, evidence has emerged indicating that group I metabotropic glutamate receptor (mGluR1 and mGluR5) antagonists have antidepressant-like activity in a variety of preclinical models. Although evidence now exists that these receptors are potential drug targets for ischemia, schizophrenia, and epilepsy, the clinical applications of agonists and antagonists are only beginning. Website=http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12838033 Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14684451 PMID: 12838033 PMID: 14684451 4.0 s59 SIMPLE_MOLECULE GTP s59 PROTEIN p8 s66 PROTEIN p11 2 s66 PROTEIN p10 s70 PROTEIN p12 2 s70 PROTEIN p10 s73 PROTEIN p8 s73 SIMPLE_MOLECULE GDP s77 PROTEIN p11 s77 PROTEIN p10 s77 PROTEIN p8 s77 SIMPLE_MOLECULE GDP s86 PROTEIN p11 s86 PROTEIN p12 s86 SIMPLE_MOLECULE Glutamate s86 PROTEIN p10 s94 PROTEIN p11 s94 PROTEIN p12 s94 SIMPLE_MOLECULE Glutamate s94 PROTEIN p10 s94 PROTEIN p8 s94 SIMPLE_MOLECULE GDP s100 PROTEIN p7 s100 SIMPLE_MOLECULE Glutamate s103 PROTEIN p6 s103 SIMPLE_MOLECULE Glutamate s77 PROTEIN p12 SQUARE_CLOSEUP_NORTHEAST SQUARE active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Bandrowski Anita SRI International ER cytosol Long Name: Glutamate Synonym: Synonym not specified Accession: S01769 inside SIMPLE_MOLECULE Glutamate Long Name: 1,4,5-Trisphosphate Synonym: Synonym not specified Accession: S01772 inside SIMPLE_MOLECULE IP_sub_3 Long Name: Ca2+ Synonym: Synonym not specified Accession: U02476 inside ION Ca_super_2+ Long Name: GTP Synonym: Synonym not specified Accession: S01771 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01774 inside SIMPLE_MOLECULE GDP Long Name: Phosphatidylinositol-4,5-bisphosphate Synonym: Synonym not specified Accession: S01770 inside SIMPLE_MOLECULE PIP2 Long Name: Diacylglycerol Synonym: Synonym not specified Accession: S01773 inside SIMPLE_MOLECULE DAG Long Name: Ca2+ Synonym: Synonym not specified Accession: U02476 inside ION Ca_super_2+ Long Name: Protein Kinase A Synonym: PKA Accession: P01059 inside PROTEIN p5 Long Name: inositol 1,4,5-triphosphate receptor Synonym: ITPR Accession: P01056 transmembrane PROTEIN p4 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05384 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S01771##;G-Protein#PROTEIN#Gq#P01057## inside COMPLEX Complex_br_(GTP/G-Protein) Long Name: Phospholipase C Synonym: PLC Accession: P01053 inside PROTEIN p2 Long Name: Protein kinase C Synonym: PKC Accession: P01055 inside PROTEIN p9 Long Name: Homer Synonym: Synonym not specified Accession: P01058 inside PROTEIN p10 Long Name: Metabotropic glutamate receptor 1 Synonym: mGlu 1,mGlu1,mGluR1 Accession: P01062 transmembrane PROTEIN p11 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05392 Heterodimer Member Info: Homer#PROTEIN#Homer#P01058##;mGluR1#PROTEIN#Metabotropic glutamate receptor 1#P01062#mGlu 1|mGlu1|mGluR1# transmembrane COMPLEX Complex_br_(mGluR1/Homer) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05386 Heterodimer Member Info: Homer#PROTEIN#Homer#P01058##;mGluR5#PROTEIN#metabotropic glutamate receptor 5#P01061#GRM5|mGlu 5|mGlu5|mGluR5# transmembrane COMPLEX Complex_br_(mGluR5/Homer) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05385 Heterodimer Member Info: G-Protein#PROTEIN#Gq#P01057##;GDP#SIMPLE_MOLECULE#GDP#S01774## inside COMPLEX Complex_br_(G-Protein/GDP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05388 Heterodimer Member Info: G-Protein#PROTEIN#Gq#P01057##;Homer#PROTEIN#Homer#P01058##;mGluR5#PROTEIN#metabotropic glutamate receptor 5#P01061#GRM5|mGlu 5|mGlu5|mGluR5#;mGluR1#PROTEIN#Metabotropic glutamate receptor 1#P01062#mGlu 1|mGlu1|mGluR1#;GDP#SIMPLE_MOLECULE#GDP#S01774## transmembrane COMPLEX Complex_br_(mGluR1/mGluR5/_br_Homer/G-Protein/_br_GDP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05387 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01769##;Homer#PROTEIN#Homer#P01058##;mGluR5#PROTEIN#metabotropic glutamate receptor 5#P01061#GRM5|mGlu 5|mGlu5|mGluR5#;mGluR1#PROTEIN#Metabotropic glutamate receptor 1#P01062#mGlu 1|mGlu1|mGluR1# transmembrane COMPLEX Complex_br_(mGluR1/mGluR5/_br_Glutamate/Homer) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05391 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01769##;G-Protein#PROTEIN#Gq#P01057##;Homer#PROTEIN#Homer#P01058##;mGluR5#PROTEIN#metabotropic glutamate receptor 5#P01061#GRM5|mGlu 5|mGlu5|mGluR5#;mGluR1#PROTEIN#Metabotropic glutamate receptor 1#P01062#mGlu 1|mGlu1|mGluR1#;GDP#SIMPLE_MOLECULE#GDP#S01774## transmembrane COMPLEX Complex_br_(mGluR1/mGluR5/_br_Glutamate/Homer/_br_G-Protein/GDP) Long Name: Kainate Receptor Synonym: Glu5,GluR5,KA Receptor Accession: P01054 transmembrane PROTEIN p6 Long Name: N-methyl-D-aspartate Receptor Synonym: Synonym not specified Accession: P01060 transmembrane PROTEIN p7 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05390 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01769##;NMDA#PROTEIN#N-methyl-D-aspartate Receptor#P01060## transmembrane COMPLEX Complex_br_(NMDA/Glutamate) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05389 Heterodimer Member Info: Glutamate#SIMPLE_MOLECULE#Glutamate#S01769##;GluR5#PROTEIN#Kainate Receptor#P01054#Glu5|GluR5|KA Receptor# transmembrane COMPLEX Complex_br_(GluR5/Glutamate) transmembrane PROTEIN p12 DISSOCIATION 0.2157327670105076,0.29593305044806595 a13 a14 a15 a66 TRANSPORT 0.32679738562091254,1.7763568394002505E-15 a17 a18 a57 STATE_TRANSITION a68 a69 a15 STATE_TRANSITION a67 a53 a69 STATE_TRANSITION a11 a66 a65 HETERODIMER_ASSOCIATION 0.5164557198821833,3.9281643849831127E-4 0.12208832700905448,0.2020763672339747 a71 a49 a74 HETERODIMER_ASSOCIATION 0.5176778420210315,-0.0066971535611668465 0.14953369172263775,0.44060881494688964 a72 a49 a80 HETERODIMER_ASSOCIATION 0.9545373614641747,-0.21063380715404445 0.8757385685588595,-0.3297806352687026 82.92595758518102,-34.64913228824792 a71 a72 a86 a49 a90 HETERODIMER_ASSOCIATION 0.46273263530602904,-0.04344207358702579 0.4548503003365152,0.39222971515350347 a4 a90 a112 DISSOCIATION 0.2942332875971658,2.6478716746392017E-4 0.7285404939813986,-1.4828251206777665E-4 0.1897688018017003,0.5072236116711286 a112 a19 a65 a100 a75 STATE_TRANSITION a16 a57 a14 STATE_TRANSITION a114 a119 a118 a69 STATE_TRANSITION a116 a119 a123 a69