Panther Pathway: P00045 Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade. It plays a key role in modulating cell fate decisions throughout the development of invertebrate and vertebrate species. A number of human diseases have been associated with mistakes of Notch function. Medline=11112321 Medline=12366684 Medline=12651094 Medline=12676578 Medline=14973298 PMID: 11112321 PMID: 12366684 PMID: 12651094 PMID: 12676578 PMID: 14973298 4.0 s32 PROTEIN p15 s32 PROTEIN p17 s35 PROTEIN p16 s35 PROTEIN p15 s35 PROTEIN p18 s35 PROTEIN p9 s18 PROTEIN p4 s18 PROTEIN p7 s53 PROTEIN p24 s53 PROTEIN p1 s60 PROTEIN p24 s60 PROTEIN p7 s67 PROTEIN p1 s67 PROTEIN p4 s74 PROTEIN p27 s74 PROTEIN p26 s74 PROTEIN p22 s74 PROTEIN p11 SQUARE_CLOSEUP_NORTH SQUARE_CLOSEUP_NORTH inactive inactive active active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive McCormick Mark SRI International cytosol nucleus Long Name: Fringe Synonym: Lunatic Fringe,Manic Fringe,Radical Fringe Accession: P01107 inside PROTEIN p2 Long Name: Fucose Synonym: Synonym not specified Accession: S01795 inside SIMPLE_MOLECULE fucose Long Name: Delta Synonym: Delta-like1,Delta-like3,Delta-like4,DeltaC,LAG-2 Accession: P01116 inside PROTEIN p4 Long Name: Notch intracellular tethered fragment Synonym: Synonym not specified Accession: P01119 transmembrane PROTEIN p8 Long Name: Notch transmembrane domain fragment Synonym: Synonym not specified Accession: P01114 transmembrane PROTEIN p10 Long Name: TACE Synonym: A disintegrin and metalloproteinase domain 17,ADAM17,Tumor necrosis factor alpha converting enzyme Accession: P01105 transmembrane PROTEIN p12 Long Name: a7_degraded Synonym: Synonym not specified Accession: U02511 inside DEGRADED a7_degraded Long Name: Neuralized Synonym: Neu Accession: P01117 inside PROTEIN p13 Long Name: Numb Synonym: Synonym not specified Accession: P01118 inside PROTEIN p14 Long Name: Mastermind Synonym: MECT-1,Mastermind-like 1 (MAML1),Mastermind-like2 (MAML2),Mastermind-like3(MAML3),mucoepidermoid carcinoma-translocated 1 Accession: P01106 inside PROTEIN p16 Long Name: Suppressor of Hairless [Su(H)] Synonym: C-promoter binding factor 1,CBF1,IKJRB1,Immunoglobulin Kappa J region recombination signal-binding protein 1,LAG-1 Accession: P01101 inside PROTEIN p15 Long Name: Co-repressors Synonym: Synonym not specified Accession: P01112 inside PROTEIN p17 Long Name: Long Name: Suppressor of Hairless and Co-repressors Synonym: Synonym not specified Accession: U05412 Heterodimer Member Info: Su(H)#PROTEIN#Suppressor of Hairless [Su(H)]#P01101#C-promoter binding factor 1|CBF1|IKJRB1|Immunoglobulin Kappa J region recombination signal-binding protein 1|LAG-1#;CoR#PROTEIN#Co-repressors#P01112## inside COMPLEX Complex_br_(Su(H)/CoR) Long Name: Co-Activators Synonym: Synonym not specified Accession: P01100 inside PROTEIN p18 Long Name: Notch intracellular soluble fragment Synonym: Synonym not specified Accession: P01120 inside PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05413 Heterodimer Member Info: CoA#PROTEIN#Co-Activators#P01100##;Su(H)#PROTEIN#Suppressor of Hairless [Su(H)]#P01101#C-promoter binding factor 1|CBF1|IKJRB1|Immunoglobulin Kappa J region recombination signal-binding protein 1|LAG-1#;Mastermind#PROTEIN#Mastermind#P01106#MECT-1|Mastermind-like 1 (MAML1)|Mastermind-like2 (MAML2)|Mastermind-like3(MAML3)|mucoepidermoid carcinoma-translocated 1#;NIcs#PROTEIN#Notch intracellular soluble fragment#P01120## inside COMPLEX Complex_br_(Mastermind/Su(H)/_br_CoA/NI_sub_c_sub_s) Long Name: Notch intracellular soluble fragment Synonym: Synonym not specified Accession: P01120 inside PROTEIN p9 Long Name: Sel 10 Synonym: Synonym not specified Accession: P01102 inside PROTEIN p20 Long Name: Ubiquitin Synonym: Synonym not specified Accession: S01796 inside SIMPLE_MOLECULE Ub Long Name: a46_degraded Synonym: Synonym not specified Accession: U02510 inside DEGRADED a46_degraded Long Name: Notch Synonym: GLP-1,LIN-12,Notch1,Notch2,Notch3,Notch4 Accession: P01099 transmembrane PROTEIN p1 Long Name: Long Name: Delta and Notch extracellular fragment Synonym: Synonym not specified Accession: U05409 Heterodimer Member Info: Next#PROTEIN#Serrate and Notch extracellular fragment#P01103##;Delta#PROTEIN#Delta#P01116#Delta-like1|Delta-like3|Delta-like4|DeltaC|LAG-2# inside COMPLEX Complex_br_(Delta/N_sub_ext) Long Name: Notch Synonym: GLP-1,LIN-12,Notch1,Notch2,Notch3,Notch4 Accession: P01099 transmembrane PROTEIN p1 Long Name: Neurotic Synonym: O-fucosyltransferase 1,O-fut1,OFUT1,Ofut1 Accession: P01115 inside PROTEIN p21 Long Name: Serrate Synonym: APX-1,F16B12.2,Jagged1,Jagged2 Accession: P01104 inside PROTEIN p24 Long Name: Long Name: Serrate and Notch (fucosylated) Synonym: Synonym not specified Accession: U05410 Heterodimer Member Info: Notch#PROTEIN#Notch#P01099#GLP-1|LIN-12|Notch1|Notch2|Notch3|Notch4#;Serrate#PROTEIN#Serrate#P01104#APX-1|F16B12.2|Jagged1|Jagged2# transmembrane COMPLEX Complex_br_(Serrate/Notch) Long Name: Long Name: Serrate and Notch extracellular fragment Synonym: Synonym not specified Accession: U05414 Heterodimer Member Info: Next#PROTEIN#Serrate and Notch extracellular fragment#P01103##;Serrate#PROTEIN#Serrate#P01104#APX-1|F16B12.2|Jagged1|Jagged2# inside COMPLEX Complex_br_(Serrate/N_sub_ext) Long Name: Notch intracellular soluble fragment Synonym: Synonym not specified Accession: P01120 inside PROTEIN p9 Long Name: a25_degraded Synonym: Synonym not specified Accession: U02509 inside DEGRADED a25_degraded Long Name: LNXp80 Synonym: Ligand of Numb-protein X 80 kDa Accession: P01111 inside PROTEIN p25 Long Name: Long Name: Delta and Notch (fucosylated) Synonym: Synonym not specified Accession: U05411 Heterodimer Member Info: Notch#PROTEIN#Notch#P01099#GLP-1|LIN-12|Notch1|Notch2|Notch3|Notch4#;Delta#PROTEIN#Delta#P01116#Delta-like1|Delta-like3|Delta-like4|DeltaC|LAG-2# outerSurface COMPLEX Complex_br_(Notch/Delta) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05415 Heterodimer Member Info: Nicastrin#PROTEIN#Nicastrin#P01108##;Aph1#PROTEIN#Aph1#P01109#alphaprotein 1#;Presenilin#PROTEIN#Presenilin#P01110##;Pen2#PROTEIN#Pen2#P01113#Presenilin 2# transmembrane COMPLEX Complex_br_(Pen2/Aph1/_br_Nicastrin/Presenilin) Long Name: Enhancer of Split complex genes Synonym: Synonym not specified Accession: G01541 inside GENE gn1 inside RNA rn1 TRUNCATION 0.17959775642037545,-3.617195111993432E-4 0.600136554410903,0.12222623852842673 a15 a19 a16 a84 STATE_TRANSITION a7 a22 a23 TRANSPORT 0.45599620029352184,-0.011501776440290268 a16 a24 a25 DISSOCIATION 0.5507328523989337,0.007042253521134967 a37 a30 a36 a24 HETERODIMER_ASSOCIATION 0.3706563045114102,0.006601951213514923 -0.3936722810520674,0.7491239522932638 a24 a30 a27 a38 a44 STATE_TRANSITION 0.46246855623432825,0.003887875709592592 0.6250630115908518,0.008963186135123813 a24 a48 a46 a47 STATE_TRANSITION a46 a49 STATE_TRANSITION 0.33082606148100235,-6.97812805060094E-4 0.6224672382374541,6.838145185936728E-4 a3 a4 a1 a50 HETERODIMER_ASSOCIATION 0.8814149135938509,0.32033756035899175 0.8597622429427911,-0.35663865645494897 0.717423472725733,0.2505176222473646 a1 a56 a61 a2 TRUNCATION 0.9210119444700791,-0.5391662413561775 a61 a69 a15 a21 STATE_TRANSITION a25 a72 a73 HETERODIMER_ASSOCIATION 0.649176008292363,-0.004166121502869213 0.5784924869855494,0.47729949414913264 a7 a1 a77 a2 TRUNCATION 0.7723707926596051,-0.0015427661194808984 0.6464658676498471,-0.14257798815386602 a77 a18 a15 a21 TRANSCRIPTION a85 sa46 a44 a37