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<celldesigner:protein id="p25" name="dynorphin" type="GENERIC"/>
<celldesigner:protein id="p6" name="Kappa Receptor" type="RECEPTOR"/>
<celldesigner:protein id="pr12" name="provasopressin" type="GENERIC"/>
</celldesigner:listOfProteins>
<celldesigner:listOfGenes>
<celldesigner:gene id="gn2" name="prepropressophysin" type="GENE"/>
<celldesigner:gene id="gn1" name="preprodynorphin" type="GENE"/>
</celldesigner:listOfGenes>
<celldesigner:listOfRNAs>
<celldesigner:RNA id="rn2" name="prepropressophysin" type="RNA"/>
<celldesigner:RNA id="rn1" name="preprodynorphin" type="RNA"/>
</celldesigner:listOfRNAs>
<celldesigner:listOfAntisenseRNAs/>
<celldesigner:listOfLayers/>
<celldesigner:listOfBlockDiagrams/>
</celldesigner:extension>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#Opioid_space_prodynorphin_space_pathway">
<dc:creator>
<rdf:Bag>
<rdf:li rdf:parseType="Resource">
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>SRI International</vCard:Orgname>
</vCard:ORG>
</rdf:li>
</rdf:Bag>
</dc:creator>
</rdf:Description>
</rdf:RDF>
</annotation>
<listOfUnitDefinitions>
<unitDefinition metaid="substance" id="substance" name="substance">
<listOfUnits>
<unit metaid="CDMT00042" kind="mole"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="volume" id="volume" name="volume">
<listOfUnits>
<unit metaid="CDMT00043" kind="litre"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="area" id="area" name="area">
<listOfUnits>
<unit metaid="CDMT00044" kind="metre" exponent="2"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="length" id="length" name="length">
<listOfUnits>
<unit metaid="CDMT00045" kind="metre"/>
</listOfUnits>
</unitDefinition>
<unitDefinition metaid="time" id="time" name="time">
<listOfUnits>
<unit metaid="CDMT00046" kind="second"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment metaid="default" id="default" name="default" size="1" units="volume" outside="default">
<annotation>
<celldesigner:extension>
<celldesigner:name>default</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c1" id="c1" name="magnocellular cells in hypothalamus" size="1" units="volume" outside="default">
<annotation>
<celldesigner:extension>
<celldesigner:name>magnocellular cells in hypothalamus</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c2" id="c2" name="secretory vesicle" size="1" units="volume" outside="c1">
<annotation>
<celldesigner:extension>
<celldesigner:name>secretory vesicle</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c3" id="c3" name="endoplasmic reticulum" size="1" units="volume" outside="c1">
<annotation>
<celldesigner:extension>
<celldesigner:name>endoplasmic reticulum</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
<compartment metaid="c4" id="c4" name="nucleus" size="1" units="volume" outside="c1">
<annotation>
<celldesigner:extension>
<celldesigner:name>nucleus</celldesigner:name>
</celldesigner:extension>
</annotation>
</compartment>
</listOfCompartments>
<listOfSpecies>
<species metaid="s1" id="s1" name="SNARE COMPLEX" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  SNARE COMPLEX
Synonym:  Long Name:  SNARE COMPLEX
Accession:  P05996
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p24</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re10"/>
<celldesigner:catalyzed reaction="re30"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s4" id="s4" name="prodynorphin" compartment="c3" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  prodynorphin
Synonym:  Synonym not specified
Accession:  P05997
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p14</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s16" id="s16" name="vasopressin" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  vasopressin
Synonym:  ADH,Long Name:  vasopressin,antidiuretic hormone
Accession:  P06000
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s17" id="s17" name="vasopressin" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  vasopressin
Synonym:  ADH,Long Name:  vasopressin,antidiuretic hormone
Accession:  P06000
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p2</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s13" id="s13" name="prepropressophysin" compartment="c4" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  prepropressophysin
Synonym:  Synonym not specified
Accession:  G06050
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn2</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s14" id="s14" name="prepropressophysin" compartment="c4" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  prepropressophysin
Synonym:  Synonym not specified
Accession:  G06048
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn2</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s18" id="s18" name="antidiuretic effects" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  antidiuretic effects
Synonym:  Synonym not specified
Accession:  U06195
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>antidiuretic effects</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s22" id="s22" name="Complex_br_(GTP/G-protein)" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Complex (GTP/G-protein)
Synonym:  Synonym not specified
Accession:  U06191
Heterodimer Member Info:  GTP#SIMPLE_MOLECULE#GTP#S06110##;G-protein#PROTEIN#G-protein#P06002##
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(GTP/G-protein)</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re20"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s23" id="s23" name="GDP" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  GDP
Synonym:  Synonym not specified
Accession:  S06108
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GDP</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s25" id="s25" name="GTP" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  GTP
Synonym:  Synonym not specified
Accession:  S06110
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>GTP</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s26" id="s26" name="ATP" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  ATP
Synonym:  Synonym not specified
Accession:  S06109
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>ATP</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s28" id="s28" name="cAMP" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  cAMP
Synonym:  Synonym not specified
Accession:  S06111
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cAMP</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s31" id="s31" name="Complex_br_(GDP/G-protein/_br_Sigma Receptor)" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Complex (GDP/G-protein/ Sigma Receptor)
Synonym:  Synonym not specified
Accession:  U06192
Heterodimer Member Info:  GDP#SIMPLE_MOLECULE#GDP#S06108##;Kappa Receptor#PROTEIN#opioid receptor, kappa#P05998#OPRK#;G-protein#PROTEIN#G-protein#P06002##
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(GDP/G-protein/_br_Sigma Receptor)</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s54" id="s54" name="Complex_br_(Sigma Receptor/endorphins (morphine like))" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Complex (Sigma Receptor/endorphins (morphine like))
Synonym:  Synonym not specified
Accession:  U06193
Heterodimer Member Info:  Kappa Receptor#PROTEIN#opioid receptor, kappa#P05998#OPRK#;dynorphin#PROTEIN#dynorphin#P06003##
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(Sigma Receptor/endorphins (morphine like))</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s57" id="s57" name="Complex_br_(GDP/G-protein/_br_Sigma Receptor/endorphins (morphine like))" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  Complex (GDP/G-protein/ Sigma Receptor/endorphins (morphine like))
Synonym:  Synonym not specified
Accession:  U06194
Heterodimer Member Info:  GDP#SIMPLE_MOLECULE#GDP#S06108##;Kappa Receptor#PROTEIN#opioid receptor, kappa#P05998#OPRK#;G-protein#PROTEIN#G-protein#P06002##;dynorphin#PROTEIN#dynorphin#P06003##
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>Complex_br_(GDP/G-protein/_br_Sigma Receptor/endorphins (morphine like))</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s58" id="s58" name="dynorphin" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  dynorphin
Synonym:  Synonym not specified
Accession:  P06003
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p25</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s61" id="s61" name="dynorphin" compartment="c2" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  dynorphin
Synonym:  Synonym not specified
Accession:  P06003
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p25</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s65" id="s65" name="preprodynorphin" compartment="c4" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  preprodynorphin
Synonym:  Synonym not specified
Accession:  G06047
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>GENE</celldesigner:class>
<celldesigner:geneReference>gn1</celldesigner:geneReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s66" id="s66" name="preprodynorphin" compartment="c4" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  preprodynorphin
Synonym:  Synonym not specified
Accession:  G06049
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>RNA</celldesigner:class>
<celldesigner:rnaReference>rn1</celldesigner:rnaReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s67" id="s67" name="provasopressin" compartment="c3" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  provasopressin
Synonym:  Synonym not specified
Accession:  P05999
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr12</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s68" id="s68" name="analgesic_br_pain relief" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  analgesic pain relief
Synonym:  Synonym not specified
Accession:  U06197
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PHENOTYPE</celldesigner:class>
<celldesigner:name>analgesic_br_pain relief</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s69" id="s69" name="AC" compartment="default" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  adenylate cyclase
Synonym:  Long Name:  AC,adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase
Accession:  P06001
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p7</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re19"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s12" id="s12" name="dehydration or salt loading stress" compartment="c1" initialAmount="0">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<body>
Long Name:  dehydration or salt loading stress
Synonym:  Synonym not specified
Accession:  U06196
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>UNKNOWN</celldesigner:class>
<celldesigner:name>dehydration or salt loading stress</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re36"/>
<celldesigner:catalyzed reaction="re37"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
</listOfSpecies>
<listOfReactions>
<reaction metaid="re10" id="re10" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s16" alias="a16"/>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s17" alias="a17"/>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="1">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
<celldesigner:lineDirection index="1" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.38946378774057266,0.002952894399716577</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s1" aliases="a2" targetLineIndex="-1,3">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1" alias="a2">
<celldesigner:linkAnchor position="S"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00002" species="s16">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00003" species="s17">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00004" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re12" id="re12" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
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<celldesigner:baseProducts>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00005" species="s66">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a11</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00006" species="s4">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re19" id="re19" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s28" alias="a28"/>
</celldesigner:baseProducts>
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</celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00007" species="s26">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a26</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00008" species="s28">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a28</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00009" species="s69">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re20" id="re20" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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<celldesigner:linkTarget species="s22" alias="a22">
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00010" species="s69">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a30</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00011" species="s69">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a29</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00012" species="s22">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a22</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re28" id="re28" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s57" alias="a49">
<celldesigner:linkAnchor position="WNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown"/>
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<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00013" species="s58">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a43</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00014" species="s31">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a32</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00015" species="s57">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a49</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re29" id="re29" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType>
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<celldesigner:linkAnchor position="ESE"/>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
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<celldesigner:baseProduct species="s54" alias="a46">
<celldesigner:linkAnchor position="WSW"/>
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</celldesigner:baseProducts>
<celldesigner:listOfReactantLinks>
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<celldesigner:line width="1.0" color="ff000000" type="Curve"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
<celldesigner:listOfProductLinks>
<celldesigner:productLink product="s23" alias="a23" targetLineIndex="-1,1">
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<celldesigner:lineDirection arm="2" index="0" value="unknown"/>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00016" species="s57">
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<celldesigner:alias>a49</celldesigner:alias>
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</speciesReference>
<speciesReference metaid="CDMT00017" species="s25">
<annotation>
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</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00018" species="s54">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a46</celldesigner:alias>
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</annotation>
</speciesReference>
<speciesReference metaid="CDMT00019" species="s22">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a22</celldesigner:alias>
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</annotation>
</speciesReference>
<speciesReference metaid="CDMT00020" species="s23">
<annotation>
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<celldesigner:alias>a23</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
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<celldesigner:extension>
<celldesigner:reactionType>TRANSPORT</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:baseProducts>
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<celldesigner:linkTarget species="s1" alias="a2">
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:listOfModification>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00021" species="s61">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa37</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00022" species="s58">
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<celldesigner:extension>
<celldesigner:alias>a43</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00023" species="s1">
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<celldesigner:alias>a2</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
<reaction metaid="re32" id="re32" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
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</celldesigner:baseReactants>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00024" species="s4">
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<celldesigner:alias>a6</celldesigner:alias>
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</annotation>
</speciesReference>
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<celldesigner:extension>
<celldesigner:alias>sa37</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
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<celldesigner:extension>
<celldesigner:reactionType>KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
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<celldesigner:extension>
<celldesigner:alias>a14</celldesigner:alias>
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</annotation>
</speciesReference>
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<celldesigner:extension>
<celldesigner:alias>sa38</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
</reaction>
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<celldesigner:reactionType>KNOWN_TRANSITION_OMITTED</celldesigner:reactionType>
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</celldesigner:baseProducts>
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00028" species="s67">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa38</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>a16</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re36" id="re36" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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</celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s12" alias="a12">
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<celldesigner:line width="1.0" color="ff000000"/>
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</annotation>
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<celldesigner:extension>
<celldesigner:alias>a10</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfReactants>
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<speciesReference metaid="CDMT00031" species="s66">
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<celldesigner:extension>
<celldesigner:alias>a11</celldesigner:alias>
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</annotation>
</speciesReference>
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<celldesigner:extension>
<celldesigner:alias>a12</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<celldesigner:extension>
<celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType>
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</celldesigner:listOfLineDirection>
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<celldesigner:line width="1.0" color="ff000000"/>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
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<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>a13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
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<annotation>
<celldesigner:extension>
<celldesigner:alias>a14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00035" species="s12">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a12</celldesigner:alias>
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</annotation>
</modifierSpeciesReference>
</listOfModifiers>
</reaction>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>PHYSICAL_STIMULATION</celldesigner:reactionType>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s18" alias="a18">
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
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</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00036" species="s17">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a17</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00037" species="s18">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re39" id="re39" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>PHYSICAL_STIMULATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s28" alias="a28">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s68" alias="sa39">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00038" species="s28">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a28</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00039" species="s68">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa39</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
<reaction metaid="re40" id="re40" reversible="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>PHYSICAL_STIMULATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s28" alias="a28">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s18" alias="a18">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00040" species="s28">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a28</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00041" species="s18">
<annotation>
<celldesigner:extension>
<celldesigner:alias>a18</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
</reaction>
</listOfReactions>
</model>
</sbml>

