Panther Pathway: P00046 Oxidative stress is a pathogenic condition that causes cellular damage. In a normal functioning cell, several transcription factors respond to this threat by modulating expression of genes whose products relieve the altered redox status. This pathway illustrates some of the intracellular signalling response regulating such gene expression. Medline=10207617 Medline=10487205 Medline=10557107 Medline=11274345 Medline=12115731 Website=www.cellsignal.com (copyright 2002 Cell Signalling Technology, Inc.) PMID: 10207617 PMID: 10487205 PMID: 10557107 PMID: 11274345 PMID: 12115731 4.0 s22 PROTEIN p7 s22 PROTEIN p8 s56 PROTEIN p17 s56 PROTEIN p18 SQUARE_CLOSEUP_NORTH SQUARE inactive inactive inactive active inactive inactive active inactive inactive active inactive inactive inactive active inactive active active active inactive active inactive active inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Nonn Larisa SRI International cytosol nucleus Long Name: p38 MAP Kinase Synonym: CSBP1,EXIP,MAPK14,Mxi2,RK,SAPK2A Accession: P01135 inside PROTEIN p3 Long Name: jun sarcoma virus 17 oncogene homolog Synonym: Synonym not specified Accession: P01132 inside PROTEIN p4 Long Name: jun sarcoma virus 17 oncogene homolog Synonym: Synonym not specified Accession: P01132 inside PROTEIN p4 Long Name: Cell Survival Synonym: Synonym not specified Accession: U02518 inside PHENOTYPE Cell_br_Survival Long Name: Cell Death Synonym: Synonym not specified Accession: U02517 inside PHENOTYPE Cell_br_Death Long Name: apoptosis signal regulating kinase 1 Synonym: MAP/ERK KINASE KINASE 5,MAPKKK5,MEKK5 Accession: P01139 inside PROTEIN p8 Long Name: thioredoxin Synonym: Synonym not specified Accession: P01122 inside PROTEIN p7 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05439 Heterodimer Member Info: TRX#PROTEIN#thioredoxin#P01122##;ASK-1#PROTEIN#apoptosis signal regulating kinase 1#P01139#MAP/ERK KINASE KINASE 5|MAPKKK5|MEKK5# inside COMPLEX Complex_br_(TRX/ASK-1) Long Name: MKK4 Synonym: JNKK,MAPKK4,MEK4,PRKMK4,SEK1 Accession: P01138 inside PROTEIN p9 Long Name: MKK4 Synonym: JNKK,MAPKK4,MEK4,PRKMK4,SEK1 Accession: P01138 inside PROTEIN p9 Long Name: Map Kinase Kinase 3 and Map Kinase Kinase 6 Synonym: MAPK/ERK KINASE 3,MAPK/ERK kinase 6,MAPKK3,MAPKK6,MEK3,MEK6,PRKMK3,PRKMK6,PROTEIN KINASE MITOGEN-ACTIVATED KINASE 3 Accession: P01121 inside PROTEIN p10 Long Name: Map Kinase Kinase 3 and Map Kinase Kinase 6 Synonym: MAPK/ERK KINASE 3,MAPK/ERK kinase 6,MAPKK3,MAPKK6,MEK3,MEK6,PRKMK3,PRKMK6,PROTEIN KINASE MITOGEN-ACTIVATED KINASE 3 Accession: P01121 inside PROTEIN p10 Long Name: p38 MAP Kinase Synonym: CSBP1,EXIP,MAPK14,Mxi2,RK,SAPK2A Accession: P01135 inside PROTEIN p3 Long Name: elongation factor 2 kinase Synonym: Calmodulin-dependent protein kinase III Accession: P01127 inside PROTEIN p11 Long Name: Translation Synonym: Synonym not specified Accession: U02516 inside PHENOTYPE Translation Long Name: p38 MAP Kinase Synonym: CSBP1,EXIP,MAPK14,Mxi2,RK,SAPK2A Accession: P01135 inside PROTEIN p3 Long Name: ELK-1 protein Synonym: ELK1 member of ETS oncogene family Accession: P01136 inside PROTEIN p15 Long Name: ELK-1 protein Synonym: ELK1 member of ETS oncogene family Accession: P01136 inside PROTEIN p15 Long Name: Activating Transcription Factor 2 Synonym: CRE-BP1,TREB7,cAMP responsive element binding protein 2 Accession: P01126 inside PROTEIN p16 Long Name: Activating Transcription Factor 2 Synonym: CRE-BP1,TREB7,cAMP responsive element binding protein 2 Accession: P01126 inside PROTEIN p16 Long Name: ATP Synonym: Synonym not specified Accession: S01797 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01798 inside SIMPLE_MOLECULE ADP Long Name: MAPK-interacting kinases 1/2 Synonym: GPRK7,MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1,MKNK1,MKNK2,MNK1,MNK2 Accession: P01137 inside PROTEIN p12 Long Name: MAPK-interacting kinases 1/2 Synonym: GPRK7,MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1,MKNK1,MKNK2,MNK1,MNK2 Accession: P01137 inside PROTEIN p12 Long Name: MAP Kinase Phosphatases Synonym: HePTP,M3/6,MKP-1,MKP-2,MKP-4,MKP-5,MKP-6,PAC-1,PP2A,Wip1 Accession: P01131 inside PROTEIN p14 Long Name: cytosolic phospholipase A2, group IVA Synonym: PLA2G4,cPLA2-alpha Accession: P01134 inside PROTEIN p13 Long Name: cytosolic phospholipase A2, group IVA Synonym: PLA2G4,cPLA2-alpha Accession: P01134 inside PROTEIN p13 Long Name: ADP Synonym: Synonym not specified Accession: S01798 inside SIMPLE_MOLECULE ADP Long Name: ATP Synonym: Synonym not specified Accession: S01797 inside SIMPLE_MOLECULE ATP Long Name: v-myc myelocytomatosis viral oncogene homolog Synonym: c-myc Accession: P01124 inside PROTEIN p18 Long Name: myc-associated factor X Synonym: Synonym not specified Accession: P01133 inside PROTEIN p17 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05440 Heterodimer Member Info: Myc#PROTEIN#v-myc myelocytomatosis viral oncogene homolog#P01124#c-myc#;Max#PROTEIN#myc-associated factor X#P01133## inside COMPLEX Complex_br_(Max/Myc) Long Name: reactive oxygen species Synonym: Synonym not specified Accession: U02515 inside UNKNOWN Oxidative Stress_br_ROS, UV Long Name: signal transducer and activator of transcription 1 Synonym: ISGF-3,STAT91 Accession: P01125 inside PROTEIN p19 Long Name: signal transducer and activator of transcription 1 Synonym: ISGF-3,STAT91 Accession: P01125 inside PROTEIN p19 Long Name: C/EBP-homologous protein Synonym: CEBPZ,DDIT3,GADD153 Accession: P01130 inside PROTEIN p20 Long Name: C/EBP-homologous protein Synonym: CEBPZ,DDIT3,GADD153 Accession: P01130 inside PROTEIN p20 Long Name: myocyte enhancer factor-2 Synonym: ADCAD1,MADS box transcription enhancer factor 2,MEF2A,MEF2B,MEF2C,MEF2D Accession: P01128 inside PROTEIN p21 Long Name: myocyte enhancer factor-2 Synonym: ADCAD1,MADS box transcription enhancer factor 2,MEF2A,MEF2B,MEF2C,MEF2D Accession: P01128 inside PROTEIN p21 Long Name: c-jun N-terminal kinases 1 and 2 Synonym: JNK1,JNK2,JNK55,MAPK8,MAPK9,SAPK1 Accession: P01129 inside PROTEIN p2 Long Name: c-jun N-terminal kinases 1 and 2 Synonym: JNK1,JNK2,JNK55,MAPK8,MAPK9,SAPK1 Accession: P01129 inside PROTEIN p2 Long Name: c-jun N-terminal kinases 1 and 2 Synonym: JNK1,JNK2,JNK55,MAPK8,MAPK9,SAPK1 Accession: P01129 inside PROTEIN p2 Long Name: b-cell lymphoma protein-2 Synonym: Synonym not specified Accession: P01123 inside PROTEIN p22 Long Name: b-cell lymphoma protein-2 Synonym: Synonym not specified Accession: P01123 inside PROTEIN p22 Long Name: Unknown Synonym: Synonym not specified Accession: U02514 inside UNKNOWN Unknown inside GENE gn2 inside RNA rn1 STATE_TRANSITION 0.34811903241127906,0.024985669598233784 0.5706546127516099,0.01941073388045389 a6 a68 a7 a69 a45 DISSOCIATION 0.33165556035448196,0.2511887284506109 a29 a28 a23 a2 STATE_TRANSITION 0.367147286868472,8.657977088413205E-4 0.5808169899610532,-0.0013523836929891786 a30 a60 a4 a66 a32 a41 STATE_TRANSITION 0.3801593330606333,-0.003856717115652497 0.5711642221313192,-0.0012855723718943057 a31 a61 a32 a67 a23 STATE_TRANSITION 0.34989227285233193,-1.1005523926188587E-5 0.573713729391097,-7.830853563062234E-5 a33 a56 a34 a57 a23 STATE_TRANSITION 0.3857649494668167,0.004873220643709875 0.6089358980792676,0.004856084731877264 a5 a59 a35 a65 a34 a32 a41 STATE_TRANSITION 0.3625777493920004,8.346600201503129E-4 0.6090361764154992,-8.689768075065274E-4 a37 a58 a40 a64 a35 STATE_TRANSITION 0.2785684277916971,-0.0033215495081506674 0.5125753686357761,0.003488609805269327 a42 a62 a38 a63 a40 a35 STATE_TRANSITION 0.372954643957073,3.607655877750915E-4 0.5973640571916126,-0.006154785327431966 a49 a71 a48 a70 a43 a45 STATE_TRANSITION 0.3608755844646474,-8.647616892201171E-4 0.6081043073777224,7.055457442834978E-4 a50 a72 a51 a73 a43 a45 HETERODIMER_ASSOCIATION 0.21893015961719797,-7.337552229209621E-4 0.6144071795474222,0.001410184634053735 0.006954338136576865,0.2771933297710727 a75 a74 a79 a78 a80 a43 STATE_TRANSITION 0.3402621012047309,0.0013300044750987894 0.5651033207743286,-0.0011017564113675604 a81 a83 a82 a84 a101 STATE_TRANSITION 0.3708034307719039,4.434331057616703E-4 0.587773965118477,-2.3338584516174876E-4 a86 a89 a87 a88 a43 STATE_TRANSITION 0.3768115942028851,0.004140786749555758 0.6169772256728621,0.0020703933747459047 a90 a93 a91 a92 a43 STATE_TRANSITION 0.4118372379778028,-8.881784197001252E-16 0.5844636251541293,-2.220446049250313E-15 a97 a99 a98 a100 a4 TRANSPORT a35 a43 TRANSPORT a4 a45 INHIBITION a36 a39 PHYSICAL_STIMULATION a40 a39 STATE_TRANSITION sa73 a101 a43 TRANSCRIPTION 0.40202702702703164,-0.0033783783783851717 sa74 sa75 a82 a51 a78 a91 a87 a7 a48 PHYSICAL_STIMULATION sa75 a17 PHYSICAL_STIMULATION sa75 a18 STATE_TRANSITION sa76 a36 a35