Panther Pathway: P00047 Platelet derived growth factor (PDGF) plays a critical role in cellular proliferation and development. PDGF signaling is initiated upon binding of PDGF to the PDGF receptor complex. The PDGF receptors belong to the family of receptor protein tyrosine kinases (RPTK). Upon ligand binding, the receptors chains trans-phosphorylate each other, resulting in recruitment of adaptor molecules via SH2 domains and leading to phosphorylation of other cellular proteins. Medline=1339664 Medline=7888178 Medline=973976 Website=http://www.biocarta.com/pathfiles/h_pdgfPathway.asp PMID: 1339664 PMID: 7888178 PMID: 973976 4.0 s7 PROTEIN p1 s7 PROTEIN p2 s8 PROTEIN p1 s8 PROTEIN p2 s50 PROTEIN p8 s50 PROTEIN p18 s50 PROTEIN p9 Long Name: PDGF Synonym: Platelet-derived growth factor Accession: P01170 s7 PROTEIN p42 Long Name: PDGF Synonym: Platelet-derived growth factor Accession: P01170 s8 PROTEIN p42 OVAL SQUARE_CLOSEUP_NORTHEAST SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive active active inactive inactive active inactive active inactive active inactive inactive inactive inactive active inactive inactive inactive active inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive active active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive inactive active active active active inactive active inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive active active inactive inactive inactive active active inactive active inactive inactive inactive inactive inactive active active active inactive active inactive inactive active active active active active Kretchmer Orna Avsian SRI International Endoplasmic reticulum Nucleus cytoplasm Long Name: PDGF receptor A Synonym: PDGF receptor/CSF1 receptor family,PDGFR2 Accession: P01158 transmembrane PROTEIN p1 Long Name: PDGF receptor B Synonym: PDGFRB,PDGFR,PDGFR1 Accession: P01156 transmembrane PROTEIN p2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05454 Heterodimer Member Info: PDGF receptor B#PROTEIN#PDGF receptor B#P01156# PDGFRB|PDGFR|PDGFR1#;PDGF receptor A#PROTEIN#PDGF receptor A#P01158#PDGF receptor/CSF1 receptor family|PDGFR2# transmembrane COMPLEX Complex_br_(PDGF_br_receptor A/PDGF_br_receptor B) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05453 Heterodimer Member Info: PDGF receptor B#PROTEIN#PDGF receptor B#P01156# PDGFRB|PDGFR|PDGFR1#;PDGF receptor A#PROTEIN#PDGF receptor A#P01158#PDGF receptor/CSF1 receptor family|PDGFR2# transmembrane COMPLEX Complex_br_(PDGF_br_receptor A/PDGF_br_receptor B) Long Name: STAT Synonym: STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,Signal transducers and activators of transcription Accession: P01173 inside PROTEIN p6 Long Name: STAT Synonym: STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,Signal transducers and activators of transcription Accession: P01173 inside PROTEIN p6 Long Name: Shc Synonym: Synonym not specified Accession: P01175 inside PROTEIN p18 Long Name: Son of Sevenless Synonym: SON OF SEVENLESS,SOS Accession: P01159 inside PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05455 Heterodimer Member Info: Grb2#PROTEIN#Growth Factor Receptor Binding Protein 2#P01148#Abundant SRC homology (ASH)|Grb2#;SOS#PROTEIN#Son of Sevenless#P01159#SON OF SEVENLESS|SOS#;Shc#PROTEIN#Shc#P01175## inside COMPLEX Complex_br_(Grb2/Shc/_br_SOS) Long Name: GTP Synonym: Synonym not specified Accession: S01804 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01806 inside SIMPLE_MOLECULE GDP Long Name: MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1 Synonym: ONCOGENE RAF1 Accession: P01161 inside PROTEIN p12 Long Name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 Synonym: MAPK/ERK KINASE 1,MAPKK1,MKK1,PROTEIN KINASE, MITOGEN-ACTIVATED, KINASE 1 Accession: P01162 inside PROTEIN p13 Long Name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 Synonym: MAPK/ERK KINASE 1,MAPKK1,MKK1,PROTEIN KINASE, MITOGEN-ACTIVATED, KINASE 1 Accession: P01162 inside PROTEIN p13 Long Name: Extracellular signal-regulated kinase family Synonym: ERK,Maturation- or mitogen-activated protein (MAP) kinase family Accession: P01143 inside PROTEIN p14 Long Name: Extracellular signal-regulated kinase family Synonym: ERK,Maturation- or mitogen-activated protein (MAP) kinase family Accession: P01143 inside PROTEIN p14 Long Name: MNK1/2 Synonym: MAPK-interacting kinase 1/2,MKNK1,MNK2 Accession: P01149 inside PROTEIN p33 Long Name: MNK1/2 Synonym: MAPK-interacting kinase 1/2,MKNK1,MNK2 Accession: P01149 inside PROTEIN p33 Long Name: p90RSK Synonym: RIBOSOMAL PROTEIN S6 KINASE,RPS6KA1,RSK1,p90RSK Accession: P01142 inside PROTEIN p32 Long Name: p90RSK Synonym: RIBOSOMAL PROTEIN S6 KINASE,RPS6KA1,RSK1,p90RSK Accession: P01142 inside PROTEIN p32 Long Name: MAPKAPK2 Synonym: MAPKAP kinase 2,MAPKAPK2 Accession: P01157 inside PROTEIN p34 Long Name: MAPKAPK2 Synonym: MAPKAP kinase 2,MAPKAPK2 Accession: P01157 inside PROTEIN p34 Long Name: PIP3 Synonym: Synonym not specified Accession: S01805 inside SIMPLE_MOLECULE PIP_sub_3_endsub_ Long Name: 3'-Phosphoinositide-dependent protein kinase1/2 Synonym: PDK1,PDPK1 Accession: P01164 inside PROTEIN p16 Long Name: 3'-Phosphoinositide-dependent protein kinase1/2 Synonym: PDK1,PDPK1 Accession: P01164 inside PROTEIN p16 Long Name: cytokine-responsive IkappaB kinase Synonym: IKK,IkappaB kinase Accession: P01146 inside PROTEIN p25 Long Name: cytokine-responsive IkappaB kinase Synonym: IKK,IkappaB kinase Accession: P01146 inside PROTEIN p25 Long Name: PROTEIN KINASE B-BETA Synonym: AKT2,PKB,V-AKT MURINE THYMOMA VIRAL ONCOGENE HOMOLOG 2 Accession: P01151 inside PROTEIN p10 Long Name: PROTEIN KINASE B-BETA Synonym: AKT2,PKB,V-AKT MURINE THYMOMA VIRAL ONCOGENE HOMOLOG 2 Accession: P01151 inside PROTEIN p10 Long Name: C-terminal modulator protein Synonym: CTMP Accession: P01166 inside PROTEIN p29 Long Name: Phospholipase C, gamma Synonym: PLCG,PLCGamma,Phospholipase C-148 Accession: P01171 inside PROTEIN p3 Long Name: Phospholipase C, gamma Synonym: PLCG,PLCGamma,Phospholipase C-148 Accession: P01171 inside PROTEIN p3 Long Name: Inositol 1,4,5-triphosphate Synonym: Synonym not specified Accession: S01802 inside SIMPLE_MOLECULE IP_sub_3_endsub_ Long Name: Diacylglycerol Synonym: Synonym not specified Accession: S01800 inside SIMPLE_MOLECULE DAG Long Name: Ca2+ Synonym: Synonym not specified Accession: U02524 inside ION Ca_super_2+_endsuper_ Long Name: Ca2+ Synonym: Synonym not specified Accession: U02524 inside ION Ca_super_2+_endsuper_ Long Name: c-fos Synonym: Cellular oncogene fos,Proto-oncogene protein c-fos Accession: P01145 inside PROTEIN p35 Long Name: c-fos Synonym: Cellular oncogene fos,Proto-oncogene protein c-fos Accession: P01145 inside PROTEIN p35 Long Name: ELK Synonym: MEMBER OF ETS ONCOGENE FAMILY Accession: P01140 inside PROTEIN p15 Long Name: SRF Synonym: C-FOS SERUM RESPONSE ELEMENT-BINDING FACTOR,SERUM RESPONSE FACTOR Accession: P01165 inside PROTEIN p36 Long Name: c-Myc Synonym: Synonym not specified Accession: P01172 inside PROTEIN p30 Long Name: SRF Synonym: C-FOS SERUM RESPONSE ELEMENT-BINDING FACTOR,SERUM RESPONSE FACTOR Accession: P01165 inside PROTEIN p36 Long Name: Ets Synonym: Ets transcription factors Accession: P01167 inside PROTEIN p31 Long Name: c-Myc Synonym: Synonym not specified Accession: P01172 inside PROTEIN p30 Long Name: Ets Synonym: Ets transcription factors Accession: P01167 inside PROTEIN p31 Long Name: ELK Synonym: MEMBER OF ETS ONCOGENE FAMILY Accession: P01140 inside PROTEIN p15 Long Name: Gene transcription Synonym: Synonym not specified Accession: U02523 inside PHENOTYPE Gene transcription Long Name: c-Jun Synonym: Synonym not specified Accession: P01163 inside PROTEIN p37 Long Name: c-Jun Synonym: Synonym not specified Accession: P01163 inside PROTEIN p37 Long Name: ATP Synonym: Synonym not specified Accession: S01801 inside SIMPLE_MOLECULE ATP Long Name: MAPKAPK2 Synonym: MAPKAP kinase 2,MAPKAPK2 Accession: P01157 inside PROTEIN p34 Long Name: p90RSK Synonym: RIBOSOMAL PROTEIN S6 KINASE,RPS6KA1,RSK1,p90RSK Accession: P01142 inside PROTEIN p32 Long Name: ADP Synonym: Synonym not specified Accession: S01803 inside SIMPLE_MOLECULE ADP Long Name: Extracellular signal-regulated kinase family Synonym: ERK,Maturation- or mitogen-activated protein (MAP) kinase family Accession: P01143 inside PROTEIN p14 Long Name: GSK3 Synonym: GLYCOGEN SYNTHASE KINASE 3 Accession: P01153 inside PROTEIN p17 Long Name: GSK3 Synonym: GLYCOGEN SYNTHASE KINASE 3 Accession: P01153 inside PROTEIN p17 Long Name: BAD Synonym: BCL2 ANTAGONIST OF CELL DEATH,BCL2-BINDING PROTEIN,BCL2L8 Accession: P01141 inside PROTEIN p22 Long Name: BAD Synonym: BCL2 ANTAGONIST OF CELL DEATH,BCL2-BINDING PROTEIN,BCL2L8 Accession: P01141 inside PROTEIN p22 Long Name: mTOR Synonym: FK506-BINDING PROTEIN 12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1,FRAP,mTOR Accession: P01144 inside PROTEIN p26 Long Name: mTOR Synonym: FK506-BINDING PROTEIN 12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1,FRAP,mTOR Accession: P01144 inside PROTEIN p26 Long Name: PROTEIN KINASE B-BETA Synonym: AKT2,PKB,V-AKT MURINE THYMOMA VIRAL ONCOGENE HOMOLOG 2 Accession: P01151 inside PROTEIN p10 Long Name: Ras GTPase Activity Protein Synonym: RasGAP Accession: P01152 inside PROTEIN p19 Long Name: Ras GTPase Activity Protein Synonym: RasGAP Accession: P01152 inside PROTEIN p19 Long Name: ATP Synonym: Synonym not specified Accession: S01801 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01803 inside SIMPLE_MOLECULE ADP Long Name: Jak Synonym: Janus kinase Accession: P01155 inside PROTEIN p4 Long Name: Jak Synonym: Janus kinase Accession: P01155 inside PROTEIN p4 Long Name: Ras Synonym: Synonym not specified Accession: P01154 inside PROTEIN p11 Long Name: PHOSPHATIDYLINOSITOL 3-KINASE, CATALYTIC, ALPHA Synonym: Synonym not specified Accession: P01168 inside PROTEIN p7 Long Name: PIP2 Synonym: Synonym not specified Accession: S01799 inside SIMPLE_MOLECULE PIP_sub_2_endsub_ Long Name: Protein kinase C Synonym: Synonym not specified Accession: P01150 inside PROTEIN p5 Long Name: Nck Synonym: GRB4,MELANOMA NCK PROTEIN,NCK ADAPTOR PROTEIN Accession: P01147 inside PROTEIN p38 Long Name: Nck Synonym: GRB4,MELANOMA NCK PROTEIN,NCK ADAPTOR PROTEIN Accession: P01147 inside PROTEIN p38 Long Name: Vav Synonym: family of guanine nucleotide exchange factors for Rho family GTPases Accession: P01169 inside PROTEIN p40 Long Name: Vav Synonym: family of guanine nucleotide exchange factors for Rho family GTPases Accession: P01169 inside PROTEIN p40 Long Name: GTPase-activating protein Rho Synonym: Rho-GTPase-activating protein,RhoGAP Accession: P01174 inside PROTEIN p41 Long Name: PDGF Synonym: Platelet-derived growth factor Accession: P01170 inside PROTEIN p42 Long Name: STAT Synonym: STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,Signal transducers and activators of transcription Accession: P01173 inside PROTEIN p6 2 Long Name: STAT Synonym: STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,Signal transducers and activators of transcription Accession: P01173 inside PROTEIN p6 2 Long Name: IP3 receptor Synonym: INOSITOL 1,4,5-TRIPHOSPHATE RECEPTOR Accession: P01160 transmembrane PROTEIN p44 Long Name: Pi Synonym: Synonym not specified Accession: U02522 inside ION P_sub_i_endsub_ Long Name: STAT Synonym: STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,Signal transducers and activators of transcription Accession: P01173 inside PROTEIN p6 2 inside PROTEIN p8 STATE_TRANSITION a12 a13 STATE_TRANSITION 0.36631996633199027,-0.002725505521155913 0.5777855884270839,-0.0018159759637592643 a53 a50 a52 a51 a49 STATE_TRANSITION 0.3818050934086451,-0.0030594157293768465 0.5925269271669196,0.003169225267024345 a48 a44 a49 a45 a48 a13 STATE_TRANSITION 0.33077513227512423,-9.259259259368768E-4 0.7153875661375659,9.259259259044583E-4 a61 a59 a62 a60 a58 a161 STATE_TRANSITION 0.3542298999232729,0.005080065159014158 0.6715465793353288,0.006193143700649717 a65 a66 a62 STATE_TRANSITION 0.4005591810027367,-0.0014689139014203434 0.5847589354284115,-0.0021444035487636626 a69 a73 a70 a74 a66 STATE_TRANSITION 0.4030128855319002,-9.668601361227935E-4 0.5896663444867443,-0.002727144526330161 a71 a75 a72 a76 a70 STATE_TRANSITION 0.334612433862433,-9.259259259284391E-4 0.6136693121693035,-0.004629629629645748 a62 a61 a64 a63 HETERODIMER_ASSOCIATION 0.5926867567891225,-1.9490398225840977E-4 9.178547501598189E-5,0.31172123954245823 a56 a57 a55 a58 a13 STATE_TRANSITION 0.383698192854826,3.2735519958615455E-4 0.5839693351275976,-2.4059192656622486E-4 a80 a79 a77 a78 a72 STATE_TRANSITION 0.3356712268261144,2.1496822594802012E-4 0.6000052364352388,-3.700024082631259E-4 a84 a83 a81 a82 a72 STATE_TRANSITION 0.34364073240653803,-2.7945521202177304E-4 0.575927159622253,2.808545020176467E-4 a88 a87 a85 a86 a72 STATE_TRANSITION a89 a90 a13 STATE_TRANSITION 0.31952838718887566,0.0033193737210299723 0.5878146861466638,0.0020106600675782182 a91 a92 a90 STATE_TRANSITION 0.3854827150078446,0.003261620010642563 0.5890999142370603,7.538861067115654E-4 a95 a93 a96 a94 a92 STATE_TRANSITION 0.2960835252209293,0.003180413689961803 0.6085601542972956,-0.0038357835901301485 a102 a103 a101 a104 a96 STATE_TRANSITION 0.41419008728211004,-0.0038790161617763275 0.6060302291926849,-1.225597523157873E-4 a100 a99 a97 a98 a101 STATE_TRANSITION 0.28835193166832696,0.0031272755899198756 0.7795142784042888,-0.00266084115644194 a101 a102 a105 a106 DISSOCIATION 0.36478721976104467,0.33503826016914395 a110 a112 a111 a109 STATE_TRANSITION 0.2634502774801719,0.005850041664543282 0.6317251387400855,0.0029250208322759708 a107 a109 a13 STATE_TRANSITION 0.3349201955900032,0.0015499584832507907 0.6227880800811851,0.003653473567666321 a108 a113 a112 TRANSPORT 0.41684855447056,-0.005935286233972548 0.6237028527666033,-0.0015316867700398973 a115 a114 a176 HETERODIMER_ASSOCIATION -5.143186215792888,2.101907306735465 a1 a2 a168 a12 STATE_TRANSITION 0.3689480218290644,3.361513228572477E-4 0.5987631856530182,-4.228652467510585E-4 a138 a134 a122 a129 a133 STATE_TRANSITION 0.3568855172626755,0.003064873491931408 0.60677634414842,0.0010905176891746748 a136 a132 a125 a127 a133 STATE_TRANSITION 0.34472714011276473,-0.004666688279087339 0.6108706832509823,6.323955736906584E-4 a135 a131 a137 a130 a133 STATE_TRANSITION a118 a117 a121 STATE_TRANSITION a126 a123 a120 STATE_TRANSITION 0.36492196194716264,-2.8496273926137405E-4 0.5866871085312271,-0.003789050052914966 a141 a142 a140 a143 a133 TRANSPORT a72 a133 STATE_TRANSITION 0.38559245146071763,-0.0029032843404070974 0.6056976955180629,-0.0014516421702017723 a145 a146 a144 a147 a156 STATE_TRANSITION 0.3683377191448489,-0.005755412314610631 0.6185499848491913,0.0013527610385040134 a151 a150 a148 a149 a156 STATE_TRANSITION 0.3892235121417187,-3.69929479139941E-4 0.6063641053208082,3.9913443804895365E-4 a155 a154 a152 a153 a156 TRANSPORT a85 a120 TRANSPORT a81 a121 TRANSPORT a101 a156 STATE_TRANSITION a159 a63 a13 STATE_TRANSITION a157 a161 a13 STATE_TRANSITION a160 a162 a13 STATE_TRANSITION 0.38522667814067835,-0.0014342515199161632 0.6187573538590674,-0.0025657166078518756 a163 a166 a164 a167 a162 STATE_TRANSITION a52 a171 TRANSPORT a171 a172 STATE_TRANSITION 0.3891213389121336,-7.105427357601002E-15 0.5899581589958156,-7.105427357601002E-15 a172 a119 a173 a124 a133 STATE_TRANSITION a175 a176 a111 PHYSICAL_STIMULATION -0.04305168339997856,-0.009206482091332457 6.791065338500601E-4,-0.2137019782412266 a137 a139 PHYSICAL_STIMULATION -0.04010049160982754,-0.014046113534547544 0.0691825280869961,-0.3260400899231426 a125 a139 PHYSICAL_STIMULATION -0.03675136451442207,-0.018137525393031595 0.15910683879689358,-0.41499740936592566 a122 a139 PHYSICAL_STIMULATION -0.03222050982173341,-0.020308152165949167 0.25209362050156325,-0.4713952896702289 a140 a139 PHYSICAL_STIMULATION a117 a139 PHYSICAL_STIMULATION a123 a139 PHYSICAL_STIMULATION a173 a139