Panther Pathway: P00048 Phosphoinositide 3-kinase (PI3K) catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, which is involved in several crucial biological processes, including cell survival, regulation of gene expression and cell metabolism, and cytoskeletal rearrangements. The PI3K pathway is also implicated in several human diseases, including diabetes and cancer. Medline=12040186 Medline=12062096 Medline=12646949 Medline=12829733 Medline=12871670 PMID: 12040186 PMID: 12062096 PMID: 12646949 PMID: 12829733 PMID: 12871670 4.0 s21 PROTEIN p3 s21 PROTEIN p4 s49 SIMPLE_MOLECULE GDP s49 PROTEIN p8 s94 PROTEIN p8 s109 PROTEIN p18 s115 PROTEIN p18 s115 PROTEIN p19 s118 SIMPLE_MOLECULE PI(3,4,5)P3 s118 PROTEIN p14 s121 SIMPLE_MOLECULE PI(3,4,5)P3 s121 PROTEIN p20 s126 PROTEIN p21 s127 SIMPLE_MOLECULE PI(3,4,5)P3 s127 PROTEIN p21 s141 PROTEIN p27 s141 PROTEIN p28 s155 PROTEIN p29 s155 PROTEIN p10 s156 PROTEIN p29 s156 PROTEIN p10 s156 PROTEIN p11 s160 PROTEIN p29 s160 PROTEIN p10 s160 PROTEIN p11 s160 PROTEIN p3 s160 PROTEIN p4 s165 PROTEIN p30 s165 PROTEIN p2 s165 PROTEIN p6 s166 PROTEIN p30 s166 PROTEIN p2 s167 PROTEIN p30 s167 PROTEIN p2 s175 PROTEIN p30 s175 PROTEIN p2 s175 PROTEIN p3 s175 PROTEIN p4 s183 PROTEIN p31 s183 PROTEIN p15 s183 PROTEIN p18 s185 PROTEIN p31 s185 PROTEIN p15 s185 PROTEIN p17 s190 PROTEIN p12 s190 PROTEIN p32 s191 PROTEIN p32 s191 PROTEIN p12 s192 PROTEIN p32 s192 PROTEIN p12 s192 PROTEIN p6 s196 PROTEIN p32 s196 PROTEIN p12 s198 PROTEIN p32 s198 PROTEIN p12 s198 PROTEIN p3 s198 PROTEIN p4 s94 SIMPLE_MOLECULE GDP s109 PROTEIN p17 s109 PROTEIN p15 s183 PROTEIN p17 s126 SIMPLE_MOLECULE PI(3,4,5)P3 s215 PROTEIN p8 s215 SIMPLE_MOLECULE GTP SQUARE_CLOSEUP_NORTH SQUARE inactive inactive inactive active active inactive active inactive active inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive McCormick Mark SRI International cytoplasm nucleus Long Name: PTEN Synonym: DAF-18,MMAC,TEP1,mutated in multiple advanced cancers,phosphatase and tensin homolog deleted on chromosome ten,tumour growth factor-beta-regulated and epithelial cell enriched phosphatase Accession: P01189 inside PROTEIN p1 Long Name: PI(3,4)P2 Synonym: Synonym not specified Accession: S01810 inside SIMPLE_MOLECULE PI(3,4)P2 Long Name: Intrinsic Tyrosine Kinase Receptor Synonym: Synonym not specified Accession: P01195 transmembrane PROTEIN p2 Long Name: p110 Synonym: Class IA PI3K catalytic subunit Accession: P01192 inside PROTEIN p4 Long Name: Long Name: p110 bound to p85 Synonym: Synonym not specified Accession: U05461 Heterodimer Member Info: p110#PROTEIN#p110#P01192#Class IA PI3K catalytic subunit#;p85#PROTEIN#p85#P01202#Class IA PI3K regulatory subunit# inside COMPLEX Complex_br_(p85/p110) Long Name: p85 Synonym: Class IA PI3K regulatory subunit Accession: P01202 inside PROTEIN p3 Long Name: SHIP Synonym: SH2-domain-containing inositol phosphatase Accession: P01200 inside PROTEIN p5 Long Name: Grb2 Synonym: Growth-factor-receptor-bound protein 2 Accession: P01178 inside PROTEIN p6 Long Name: SOS Synonym: Son of sevenless Accession: P01185 inside PROTEIN p7 Long Name: GDP Synonym: Synonym not specified Accession: S01814 inside SIMPLE_MOLECULE GDP Long Name: GTP Synonym: Synonym not specified Accession: S01812 inside SIMPLE_MOLECULE GTP Long Name: Long Name: Ras-GDP Synonym: Synonym not specified Accession: U05460 Heterodimer Member Info: Ras#PROTEIN#Ras-GDP#P01182#Retrovirus associated sequence protein bound to GDP#;GDP#SIMPLE_MOLECULE#GDP#S01814## inside COMPLEX Complex_br_(GDP/Ras) Long Name: ATP Synonym: Synonym not specified Accession: S01809 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01811 inside SIMPLE_MOLECULE ADP Long Name: Pi Synonym: Synonym not specified Accession: S01807 inside SIMPLE_MOLECULE Pi Long Name: PI(3,4,5)P3 Synonym: Synonym not specified Accession: S01813 inside SIMPLE_MOLECULE PI(3,4,5)P3 Long Name: Activated p110 Synonym: Activated Class IA PI3K catalytic subunit Accession: P01177 inside PROTEIN p9 Long Name: Insulin Receptor Synonym: DAF-2,IGF-1R,IR,IRR,Insulin Growth Factor 1 Receptor,Insulin-receptor-like receptor Accession: P01187 transmembrane PROTEIN p10 Long Name: Insulin Receptor Substrate Synonym: IRS,chico,ist-1 Accession: P01193 inside PROTEIN p11 Long Name: JAK receptor Synonym: Synonym not specified Accession: P01186 transmembrane PROTEIN p12 Long Name: JAK Synonym: JAK1,JAK2,JAK3,Janus kinase Accession: P01176 inside PROTEIN p13 Long Name: Long Name: Ras-GDP Synonym: Synonym not specified Accession: U05468 Heterodimer Member Info: Ras#PROTEIN#Ras-GDP#P01182#Retrovirus associated sequence protein bound to GDP#;GDP#SIMPLE_MOLECULE#GDP#S01814## inside COMPLEX Complex_br_(Ras/GDP) Long Name: PDK1 Synonym: 3-phosphoinositide dependent kinase 1 Accession: P01196 inside PROTEIN p14 Long Name: Gbetagamma Synonym: Heterotrimeric G-protein beta gamma subunit Accession: P01188 inside PROTEIN p18 Long Name: p101 Synonym: Class IB PI3 Kinase,Class IB phosphoinositol 3-kinase Accession: P01203 inside PROTEIN p19 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05457 Heterodimer Member Info: Gbetagamma#PROTEIN#Gbetagamma#P01188#Heterotrimeric G-protein beta gamma subunit#;Galpha#PROTEIN#Galpha#P01199##;GPCR#PROTEIN#GPCR#P01204## transmembrane COMPLEX Complex_br_(GPCR/G_sub__alpha_/_br_G_sub__beta__gamma_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05472 Heterodimer Member Info: Gbetagamma#PROTEIN#Gbetagamma#P01188#Heterotrimeric G-protein beta gamma subunit#;p101#PROTEIN#p101#P01203#Class IB PI3 Kinase|Class IB phosphoinositol 3-kinase# inside COMPLEX Complex_br_(G_sub__beta__gamma_/p101) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05473 Heterodimer Member Info: PDK1#PROTEIN#PDK1#P01196#3-phosphoinositide dependent kinase 1#;PI(3,4,5)P3#SIMPLE_MOLECULE#PI(3,4,5)P3#S01813## inside COMPLEX Complex_br_(PI(3,4,5)P3/PDK1) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05476 Heterodimer Member Info: PDK1 ACT#PROTEIN#PDK1 ACT#P01190##;PI(3,4,5)P3#SIMPLE_MOLECULE#PI(3,4,5)P3#S01813## inside COMPLEX Complex_br_(PI(3,4,5)P3/PDK1 ACT) Long Name: PKB Synonym: Akt,Protein kinase B Accession: P01179 inside PROTEIN p21 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05471 Heterodimer Member Info: PKB#PROTEIN#PKB#P01179#Akt|Protein kinase B#;PI(3,4,5)P3#SIMPLE_MOLECULE#PI(3,4,5)P3#S01813## inside COMPLEX Complex_br_(PI(3,4,5)P3/PKB) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05456 Heterodimer Member Info: PKB#PROTEIN#PKB#P01179#Akt|Protein kinase B#;PI(3,4,5)P3#SIMPLE_MOLECULE#PI(3,4,5)P3#S01813## inside COMPLEX Complex_br_(PI(3,4,5)P3/PKB) Long Name: S6K Synonym: p70 S6 kinase Accession: P01194 inside PROTEIN p22 Long Name: S6K Synonym: p70 S6 kinase Accession: P01194 inside PROTEIN p22 Long Name: GSK3 Synonym: Glycogen synthase kinase 3 Accession: P01181 inside PROTEIN p23 Long Name: GSK3 Synonym: Glycogen synthase kinase 3 Accession: P01181 inside PROTEIN p23 Long Name: Caspase-9 Synonym: Apaf-3,Cysteine containing aspartate specific protease 9,Cysteine-containing aspartate specific protease 9,ICE-LAP6,Mch6 Accession: P01197 inside PROTEIN p24 Long Name: Caspase-9 Synonym: Apaf-3,Cysteine containing aspartate specific protease 9,Cysteine-containing aspartate specific protease 9,ICE-LAP6,Mch6 Accession: P01197 inside PROTEIN p24 Long Name: Bad Synonym: Bcl-xL/Bcl-2 associated death promoter Accession: P01183 inside PROTEIN p25 Long Name: Bad Synonym: Bcl-xL/Bcl-2 associated death promoter Accession: P01183 inside PROTEIN p25 Long Name: NOS Synonym: Nitric oxide synthase Accession: P01205 inside PROTEIN p26 Long Name: NOS Synonym: Nitric oxide synthase Accession: P01205 inside PROTEIN p26 Long Name: FOXO Synonym: DAF-16,DAF_16,FKHRL1,FKHRL2,FKHRL3,FKHRL4,Forkhead box subgroup "O" protein,Forkhead transcription factor Accession: P01198 inside PROTEIN p27 Long Name: 14-3-3 Synonym: GF14 Accession: P01206 inside PROTEIN p28 Long Name: FOXO Synonym: DAF-16,DAF_16,FKHRL1,FKHRL2,FKHRL3,FKHRL4,Forkhead box subgroup "O" protein,Forkhead transcription factor Accession: P01198 inside PROTEIN p27 Long Name: Long Name: FOXO bound to 14-3-3 Synonym: Synonym not specified Accession: U05464 Heterodimer Member Info: FOXO#PROTEIN#FOXO#P01198#DAF-16|DAF_16|FKHRL1|FKHRL2|FKHRL3|FKHRL4|Forkhead box subgroup "O" protein|Forkhead transcription factor#;14-3-3#PROTEIN#14-3-3#P01206#GF14# inside COMPLEX Complex_br_(FOXO/14-3-3) Long Name: GADD45 Synonym: Synonym not specified Accession: G01544 inside GENE gn1 Long Name: Cyclin d Synonym: PRAD1: parathyroid adenomatosis 1 Accession: G01546 inside GENE gn2 Long Name: scl-1 Synonym: Synonym not specified Accession: G01545 inside GENE gn3 Long Name: IGFBP1 Synonym: Synonym not specified Accession: G01543 inside GENE gn4 Long Name: Insulin receptor ligand Synonym: IGF1,INS,Insulin,Insulin-like growth factor 1 Accession: P01191 inside PROTEIN p29 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05465 Heterodimer Member Info: IR#PROTEIN#Insulin Receptor#P01187#DAF-2|IGF-1R|IR|IRR|Insulin Growth Factor 1 Receptor|Insulin-receptor-like receptor#;IR ligand#PROTEIN#Insulin receptor ligand#P01191#IGF1|INS|Insulin|Insulin-like growth factor 1# transmembrane COMPLEX Complex_br_(IR ligand/IR) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05475 Heterodimer Member Info: IR#PROTEIN#Insulin Receptor#P01187#DAF-2|IGF-1R|IR|IRR|Insulin Growth Factor 1 Receptor|Insulin-receptor-like receptor#;IR ligand#PROTEIN#Insulin receptor ligand#P01191#IGF1|INS|Insulin|Insulin-like growth factor 1#;IRS#PROTEIN#Insulin Receptor Substrate#P01193#IRS|chico|ist-1# transmembrane COMPLEX Complex_br_(IR ligand/IR/_br_IRS) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05469 Heterodimer Member Info: IR#PROTEIN#Insulin Receptor#P01187#DAF-2|IGF-1R|IR|IRR|Insulin Growth Factor 1 Receptor|Insulin-receptor-like receptor#;IR ligand#PROTEIN#Insulin receptor ligand#P01191#IGF1|INS|Insulin|Insulin-like growth factor 1#;p110#PROTEIN#p110#P01192#Class IA PI3K catalytic subunit#;IRS#PROTEIN#Insulin Receptor Substrate#P01193#IRS|chico|ist-1#;p85#PROTEIN#p85#P01202#Class IA PI3K regulatory subunit# transmembrane COMPLEX Complex_br_(IR ligand/IR/_br_IRS/p85/_br_p110) Long Name: Intrinsic tyrosine kinase receptor ligand Synonym: Synonym not specified Accession: P01180 inside PROTEIN p30 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05467 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P01178#Growth-factor-receptor-bound protein 2#;ITK ligand#PROTEIN#Intrinsic tyrosine kinase receptor ligand#P01180##;Int Tyr Kin#PROTEIN#Intrinsic Tyrosine Kinase Receptor#P01195## transmembrane COMPLEX Complex_br_(ITK ligand/Int Tyr Kin/_br_Grb2) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05470 Heterodimer Member Info: ITK ligand#PROTEIN#Intrinsic tyrosine kinase receptor ligand#P01180##;Int Tyr Kin#PROTEIN#Intrinsic Tyrosine Kinase Receptor#P01195## transmembrane COMPLEX Complex_br_(ITK ligand/Int Tyr Kin) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05480 Heterodimer Member Info: ITK ligand#PROTEIN#Intrinsic tyrosine kinase receptor ligand#P01180##;Int Tyr Kin#PROTEIN#Intrinsic Tyrosine Kinase Receptor#P01195## transmembrane COMPLEX Complex_br_(ITK ligand/Int Tyr Kin) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05479 Heterodimer Member Info: ITK ligand#PROTEIN#Intrinsic tyrosine kinase receptor ligand#P01180##;p110#PROTEIN#p110#P01192#Class IA PI3K catalytic subunit#;Int Tyr Kin#PROTEIN#Intrinsic Tyrosine Kinase Receptor#P01195##;p85#PROTEIN#p85#P01202#Class IA PI3K regulatory subunit# transmembrane COMPLEX Complex_br_(ITK ligand/Int Tyr Kin/_br_p85/p110) Long Name: GPCR ligand Synonym: G-protein coupled receptor ligand Accession: P01184 inside PROTEIN p31 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05462 Heterodimer Member Info: GPCR ligand#PROTEIN#GPCR ligand#P01184#G-protein coupled receptor ligand#;Gbetagamma#PROTEIN#Gbetagamma#P01188#Heterotrimeric G-protein beta gamma subunit#;Galpha#PROTEIN#Galpha#P01199##;GPCR#PROTEIN#GPCR#P01204## transmembrane COMPLEX Complex_br_(GPCR ligand/GPCR/_br_G_sub__alpha_/G_sub__beta__gamma_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05459 Heterodimer Member Info: GPCR ligand#PROTEIN#GPCR ligand#P01184#G-protein coupled receptor ligand#;Galpha#PROTEIN#Galpha#P01199##;GPCR#PROTEIN#GPCR#P01204## transmembrane COMPLEX Complex_br_(GPCR ligand/GPCR/_br_G_sub__alpha_) Long Name: JAK ligand Synonym: Janus kinase receptor ligand Accession: P01201 inside PROTEIN p32 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05466 Heterodimer Member Info: JAK receptor#PROTEIN#JAK receptor#P01186##;JAK Ligand#PROTEIN#JAK ligand#P01201#Janus kinase receptor ligand# transmembrane COMPLEX Complex_br_(JAK receptor/JAK Ligand) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05477 Heterodimer Member Info: JAK receptor#PROTEIN#JAK receptor#P01186##;JAK Ligand#PROTEIN#JAK ligand#P01201#Janus kinase receptor ligand# transmembrane COMPLEX Complex_br_(JAK Ligand/JAK receptor) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05478 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P01178#Growth-factor-receptor-bound protein 2#;JAK receptor#PROTEIN#JAK receptor#P01186##;JAK Ligand#PROTEIN#JAK ligand#P01201#Janus kinase receptor ligand# transmembrane COMPLEX Complex_br_(JAK Ligand/JAK receptor/_br_Grb2) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05458 Heterodimer Member Info: JAK receptor#PROTEIN#JAK receptor#P01186##;JAK Ligand#PROTEIN#JAK ligand#P01201#Janus kinase receptor ligand# transmembrane COMPLEX Complex_br_(JAK Ligand/JAK receptor) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05474 Heterodimer Member Info: JAK receptor#PROTEIN#JAK receptor#P01186##;p110#PROTEIN#p110#P01192#Class IA PI3K catalytic subunit#;JAK Ligand#PROTEIN#JAK ligand#P01201#Janus kinase receptor ligand#;p85#PROTEIN#p85#P01202#Class IA PI3K regulatory subunit# transmembrane COMPLEX Complex_br_(JAK Ligand/JAK receptor/_br_p85/p110) Long Name: PI(4,5)P2 Synonym: Synonym not specified Accession: S01808 inside SIMPLE_MOLECULE PI(4,5)P2 Long Name: FOXO Synonym: DAF-16,DAF_16,FKHRL1,FKHRL2,FKHRL3,FKHRL4,Forkhead box subgroup "O" protein,Forkhead transcription factor Accession: P01198 inside PROTEIN p27 inside RNA rn1 inside RNA rn2 inside RNA rn3 inside RNA rn4 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05463 Heterodimer Member Info: Ras#PROTEIN#Ras-GDP#P01182#Retrovirus associated sequence protein bound to GDP#;GTP#SIMPLE_MOLECULE#GTP#S01812## inside COMPLEX Complex_br_(Ras/GTP) HETERODIMER_ASSOCIATION 0.25901913730867765,0.40414204763152917 a24 a19 a22 STATE_TRANSITION 0.34579464460956366,-3.9968028886505635E-15 0.6614221554962345,-4.440892098500626E-15 a6 a66 a4 a67 a72 a326 a357 STATE_TRANSITION 0.3569553711711215,-2.6645352591003757E-15 0.6372573491629439,-3.552713678800501E-15 a4 a6 a68 a1 STATE_TRANSITION 0.6343825294271106,-1.3811942726649207E-4 a4 a7 a69 a40 STATE_TRANSITION a57 a56 a339 STATE_TRANSITION a75 a72 a191 STATE_TRANSITION 0.6241956068183967,0.002233899887177815 a76 a7 a69 a78 STATE_TRANSITION 0.30795447651395236,9.260179993866302E-4 0.6924644875948474,0.004987728265395175 a77 a81 a76 a80 a193 a234 a403 STATE_TRANSITION 0.34712058849474303,-0.004170782626038871 0.6469086899101306,-9.893988091278505E-4 a76 a77 a82 a79 HETERODIMER_ASSOCIATION 0.31275851638583063,0.43223589635512605 a104 a105 a110 HETERODIMER_ASSOCIATION 0.3283187524751492,0.3933642951556706 a138 a141 a144 STATE_TRANSITION a180 a179 a390 STATE_TRANSITION 0.3781260435065654,-1.4298942161961037E-4 0.5895928413299778,7.591889455098588E-4 a190 a182 a189 a184 a179 STATE_TRANSITION 0.37307187897068417,0.005533561225912642 0.5644067876013885,0.0023581325200074943 a64 a61 a191 a60 a56 STATE_TRANSITION a192 a193 a189 HETERODIMER_ASSOCIATION 0.3813421567203914,0.38049803943415483 a220 a225 a234 HETERODIMER_ASSOCIATION 0.29265056156523706,0.36786816534805666 a194 a197 a237 STATE_TRANSITION a237 a241 HETERODIMER_ASSOCIATION 0.29629179413278806,0.3755299258726552 a242 a245 a255 STATE_TRANSITION 0.32103655791856056,-7.063662994033493E-4 0.6104812211112716,5.224015747562483E-4 a255 a258 a254 a263 a241 STATE_TRANSITION 0.3936055665106828,-0.013467032782198629 0.5885335803984049,-0.015193529307064635 a256 a261 a257 a266 a241 STATE_TRANSITION 0.3923120407009435,-0.005382233759413602 0.6229508196721056,-0.005382233759384292 a267 a259 a268 a262 a254 STATE_TRANSITION 0.40000000000000213,7.105427357601002E-15 0.6242587601078213,-2.6645352591003757E-15 a269 a260 a270 a264 a254 STATE_TRANSITION 0.33297062023940427,2.7533531010703882E-14 0.5897714907508274,1.509903313490213E-14 a273 a271 a274 a275 a254 STATE_TRANSITION 0.38695652173914397,3.552713678800501E-15 0.57826086956522,-7.105427357601002E-15 a276 a278 a277 a279 a254 STATE_TRANSITION 0.3657505550281357,-0.011855453808768068 0.5584574511400433,-0.011684284811002144 a281 a272 a282 a265 a254 HETERODIMER_ASSOCIATION 0.2500335433178025,0.3772046882652589 a282 a283 a285 TRANSPORT a281 a286 HETERODIMER_ASSOCIATION 0.38933570695352926,0.5008084005218706 a295 a83 a309 HETERODIMER_ASSOCIATION 0.46754089018724665,0.3522300283816411 a309 a100 a311 HETERODIMER_ASSOCIATION 0.11056254291880446,0.41525276264704436 a311 a110 a326 HETERODIMER_ASSOCIATION 0.14792624587803704,0.4666731407709497 a340 a47 a339 STATE_TRANSITION 0.3714594624244185,-3.489717260041214E-4 0.67141538860478,3.2958783475378617E-4 a341 a163 a340 a164 HETERODIMER_ASSOCIATION 0.09674756713918209,0.45479884308272744 a354 a22 a357 STATE_TRANSITION 0.28331105362756404,-6.597107689090276E-4 0.6417423308623178,7.985972465804902E-4 a353 a161 a354 a162 HETERODIMER_ASSOCIATION 0.5953844401222508,0.3576995832175598 a337 a8 a341 HETERODIMER_ASSOCIATION 0.557004653441096,0.3943179035023281 a337 a8 a353 HETERODIMER_ASSOCIATION 0.4642062640219997,0.35475484763250265 a365 a227 a370 DISSOCIATION 0.2070521375532266,0.38112484596201157 a370 a372 a220 HETERODIMER_ASSOCIATION 0.1316132957496583,0.46316260334387493 a388 a174 a390 STATE_TRANSITION 0.3300385853120176,4.29525658808938E-4 0.6009730893263239,-6.923377640455364E-4 a387 a165 a388 a166 a172 HETERODIMER_ASSOCIATION 0.0805269406600102,0.544553405304903 a400 a144 a403 STATE_TRANSITION 0.28070175438596223,-2.220446049250313E-16 0.6023391812865526,-8.881784197001252E-16 a399 a167 a400 a168 a148 HETERODIMER_ASSOCIATION 0.5168825709158291,0.35333302166746705 a380 a122 a387 HETERODIMER_ASSOCIATION 0.4774024716083396,0.38961604903311553 a380 a122 a399 TRANSCRIPTION a291 sa169 a286 TRANSCRIPTION a292 sa170 a286 TRANSCRIPTION a294 sa171 a286 TRANSCRIPTION a293 sa172 a286