Synaptic vesicle trafficking at the presynaptic active zone is a key process regulating synatpci transmission. The increase of Ca++ concentration triggers the docking of synatptic vesicle to the presynatpci membrane. Vesicle proteins, such as synaptotagmin and synaptobrevin, interact with syntaxin and SNAP25 on the presynaptic membrane to for the SNARE complex. The vesicle membrane then fuses with the presynptic membrane, which results in neurotransmitter release to the synatpci cleft. Subsequently, the SNARE complex is disassembled, and the vesicle is recycled. Medline=16707259 Medline=12154365 Medline=12600315 Medline=15217342 4.0 Long Name: Synaptotagmin Synonym: p65 Accession: P05769 s20 PROTEIN pr3 Long Name: Synaptobrevin Synonym: Vesicle-associated membrane protein,VAMP Accession: P05779 s20 PROTEIN pr4 Long Name: Syntaxin 1/2 Synonym: Stx1/2 Accession: P05772 s20 PROTEIN pr2 Long Name: Synaptosomal-associated protein, 25KD Synonym: Synonym not specified Accession: P05778 s20 PROTEIN pr1 Long Name: Rab3A Synonym: Synonym not specified Accession: P05780 s51 PROTEIN pr8 Long Name: Synaptobrevin Synonym: Vesicle-associated membrane protein,VAMP Accession: P05779 s51 PROTEIN pr4 Long Name: Syntaxin 1/2 Synonym: Stx1/2 Accession: P05772 s51 PROTEIN pr2 Long Name: Synaptosomal-associated protein, 25KD Synonym: Synonym not specified Accession: P05778 s51 PROTEIN pr1 Long Name: Synaptotagmin Synonym: p65 Accession: P05769 s51 PROTEIN pr3 Long Name: Ca2+ Synonym: Synonym not specified Accession: U05907 s51 ION Ca_super_2_plus_ Long Name: Munc18 Synonym: STXBP1,Syntaxin-binding protein 1 Accession: P05770 s51 PROTEIN pr6 Long Name: Rab3A-interacting protein 1alpha/2alpha Synonym: Synonym not specified Accession: P05776 s51 PROTEIN pr7 Long Name: Munc13 Synonym: UNC13 Accession: P05773 s51 PROTEIN pr12 SQUARE_CLOSEUP_SOUTH OVAL OVAL OVAL OVAL inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Presynaptic Synaptic vesicle synaptic vesicle Long Name: Syntaxin 1/2 Synonym: Stx1/2 Accession: P05772 transmembrane PROTEIN pr2 Long Name: Synaptotagmin Synonym: p65 Accession: P05769 transmembrane PROTEIN pr3 Long Name: Synaptobrevin Synonym: Vesicle-associated membrane protein,VAMP Accession: P05779 transmembrane PROTEIN pr4 Long Name: Synaptophysin Synonym: Synonym not specified Accession: P05777 transmembrane PROTEIN pr5 Long Name: SNARE complex Synonym: Synonym not specified Accession: U05903 transmembrane COMPLEX SNARE complex Long Name: Synaptosomal-associated protein, 25KD Synonym: Synonym not specified Accession: P05778 inside PROTEIN pr1 Long Name: Synaptosomal-associated protein, 25KD Synonym: Synonym not specified Accession: P05778 innerSurface PROTEIN pr1 Long Name: SNARE complex Synonym: Synonym not specified Accession: U05904 transmembrane COMPLEX SNARE complex Long Name: synaptic vesicle fusion complex Synonym: Synonym not specified Accession: U05905 transmembrane COMPLEX synaptic vesicle fusion complex Long Name: neurotransmitter Synonym: Synonym not specified Accession: S05860 inside SIMPLE_MOLECULE neurotransmitter Long Name: neurotransmitter Synonym: Synonym not specified Accession: S05860 inside SIMPLE_MOLECULE neurotransmitter Long Name: Rab3A Synonym: Synonym not specified Accession: P05780 inside PROTEIN pr8 Long Name: Ca2+ Synonym: Synonym not specified Accession: U05907 inside ION Ca_super_2_plus_ Long Name: Synapsin Synonym: Syn1,Brain protein 4.1 Accession: P05775 transmembrane PROTEIN pr9 Long Name: Synapsin Synonym: Syn1,Brain protein 4.1 Accession: P05775 transmembrane PROTEIN pr9 Long Name: Synaptophysin Synonym: Synonym not specified Accession: P05777 transmembrane PROTEIN pr5 Long Name: Synaptotagmin Synonym: p65 Accession: P05769 transmembrane PROTEIN pr3 Long Name: Synaptobrevin Synonym: Vesicle-associated membrane protein,VAMP Accession: P05779 transmembrane PROTEIN pr4 Long Name: SNARE complex dissembly Synonym: Synonym not specified Accession: U05906 inside PHENOTYPE SNARE complex dissembly Long Name: N-ethylmaleimide-sensitive factor Synonym: Synonym not specified Accession: P05774 inside PROTEIN pr10 Long Name: SNAP Synonym: Synonym not specified Accession: P05771 inside PROTEIN pr11 Long Name: Transmitter update and vesicle docking Synonym: Synonym not specified Accession: U05908 inside PHENOTYPE Transmitter update_br_and_br_vesicle docking Long Name: Munc13 Synonym: UNC13 Accession: P05773 inside PROTEIN pr12 Long Name: Munc18 Synonym: STXBP1,Syntaxin-binding protein 1 Accession: P05770 inside PROTEIN pr6 Long Name: Rab3A-interacting protein 1alpha/2alpha Synonym: Synonym not specified Accession: P05776 inside PROTEIN pr7 Long Name: Priming Synonym: Synonym not specified Accession: U05909 inside PHENOTYPE Priming Long Name: Fusion Synonym: Synonym not specified Accession: U05910 inside PHENOTYPE Fusion Long Name: Rab3A Synonym: Synonym not specified Accession: P05780 transmembrane PROTEIN pr8 Long Name: Rab3A Synonym: Synonym not specified Accession: P05780 outerSurface PROTEIN pr8 TRANSPORT sa49 sa53 csa3 STATE_TRANSITION 0.37455876022422663,3.0230719629154024E-5 csa1 sa55 sa56 sa57 sa61 sa88 csa3 HETERODIMER_ASSOCIATION 0.2178389240995502,0.2368758695316121 sa10 sa4 sa9 sa3 csa1 DISSOCIATION 0.4267560934004211,-0.00973535248766888 -0.36017254154759115,1.2086747115486496 csa3 sa74 sa75 sa56 sa57 sa55 sa78 sa79 sa88 sa80 sa81