Panther Pathway: P00053 T cell activation refers to a process in which mature T cells, which express antigen-specific T cell receptors on their surfaces, recognize their cognate antigens and respond by entering the cell cycle, secreting cytokines or lytic enzymes, and initiating the cell-based functions of the immune system. T cell signaling involves a complex network of biochemical interactions, most of which are initiated downstream of the TCR itself, but a few of which can be induced by accessory receptors. TCR signaling requires close interactions between the T cell and an antigen presenting cell, and as a result involve extensive coordination between TCR signaling networks and both cytoskeletal and membrane dynamic processes. Medline=10781399 Medline=10781404 Medline=15001169 PMID: 10781399 PMID: 10781404 PMID: 15001169 4.0 s204 PROTEIN p6 s204 PROTEIN p14 s242 PROTEIN p24 s242 SIMPLE_MOLECULE GDP s243 PROTEIN p24 s267 PROTEIN p22 s268 PROTEIN p22 s269 PROTEIN p22 s269 SIMPLE_MOLECULE GTP s269 PROTEIN p20 s270 PROTEIN p23 s270 SIMPLE_MOLECULE GTP s270 PROTEIN p21 s285 SIMPLE_MOLECULE DAG s285 PROTEIN p31 s306 PROTEIN p38 s306 PROTEIN p37 s309 PROTEIN p18 s309 PROTEIN p17 s317 PROTEIN p43 s334 SIMPLE_MOLECULE PIP2 s334 PROTEIN p46 s335 SIMPLE_MOLECULE PIP3 s335 PROTEIN p46 s343 PROTEIN p44 2 s343 PROTEIN p47 s344 PROTEIN p44 2 s344 PROTEIN p47 s362 PROTEIN p11 s362 PROTEIN p3 s362 PROTEIN p4 s362 PROTEIN p10 s362 PROTEIN p8 2 s362 PROTEIN p9 2 s370 PROTEIN p4 s370 PROTEIN p7 s370 PROTEIN p11 s370 PROTEIN p3 s370 PROTEIN p8 2 s370 PROTEIN p10 s370 PROTEIN p9 2 s384 PROTEIN p4 s384 PROTEIN p7 s384 PROTEIN p3 s384 PROTEIN p11 s384 PROTEIN p10 s384 PROTEIN p8 2 s384 PROTEIN p9 2 s398 PROTEIN p4 s398 PROTEIN p11 s398 PROTEIN p10 s398 PROTEIN p8 2 s398 PROTEIN p9 2 s398 PROTEIN p5 s398 PROTEIN p3 s419 PROTEIN p6 s419 PROTEIN p14 s437 PROTEIN p11 s437 PROTEIN p4 s437 PROTEIN p10 s437 PROTEIN p8 2 s437 PROTEIN p9 2 s437 PROTEIN p3 s442 PROTEIN p13 s442 PROTEIN p14 s442 PROTEIN p17 s442 PROTEIN p18 s442 PROTEIN p6 s449 PROTEIN p24 s449 SIMPLE_MOLECULE GTP s449 PROTEIN p25 s449 PROTEIN p27 s451 PROTEIN p36 s451 ION Ca++ s451 ION Ca++ s461 PROTEIN p13 s461 PROTEIN p6 s461 PROTEIN p14 s464 PROTEIN p13 s464 PROTEIN p16 s464 PROTEIN p6 s464 PROTEIN p14 s471 PROTEIN p13 s471 PROTEIN p21 s471 PROTEIN p6 s471 PROTEIN p14 s471 PROTEIN p20 s471 PROTEIN p15 s471 PROTEIN p19 s477 PROTEIN p6 s477 PROTEIN p14 s477 PROTEIN p15 s477 PROTEIN p19 s490 PROTEIN p24 s490 SIMPLE_MOLECULE GTP s490 PROTEIN p25 s266 PROTEIN p23 s501 PROTEIN p24 s501 SIMPLE_MOLECULE GTP s501 PROTEIN p25 Long Name: ZAP-70 Synonym: Zeta-associated protein of 70 kD Accession: P01308 s437 PROTEIN p5 s243 SIMPLE_MOLECULE GTP s267 SIMPLE_MOLECULE GDP s477 PROTEIN p13 s419 PROTEIN p13 s268 SIMPLE_MOLECULE GTP s491 PROTEIN p23 s491 SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01855 s266 SIMPLE_MOLECULE GDP s461 PROTEIN p16 s317 PROTEIN p42 s442 PROTEIN p16 SQUARE_CLOSEUP_SOUTH OVAL SQUARE SQUARE_CLOSEUP_NORTH inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active active active active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive active inactive active inactive inactive inactive active inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive active active inactive inactive active inactive inactive inactive active active inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Douglass Adam SRI International Antigen-Presenting Cell Nucleus ER T cell Long Name: Lck Synonym: Lymphocyte-specific c-src family protein tyrosine kinase Accession: P01310 inside PROTEIN p12 Long Name: CD45 Synonym: Leukocyte common antigen Accession: P01329 transmembrane PROTEIN p1 Long Name: Csk Synonym: c-src kinase Accession: P01304 inside PROTEIN p2 Long Name: LAT Synonym: Linker for Activation of T cells,pp36/38 Accession: P01325 transmembrane PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05530 Heterodimer Member Info: SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc# inside COMPLEX Complex_br_(Gads/SLP-76) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05550 Heterodimer Member Info: Ras#PROTEIN#Ras#P01306##;GDP#SIMPLE_MOLECULE#GDP#S01855## innerSurface COMPLEX Complex_br_(Ras/GDP ) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05548 Heterodimer Member Info: Ras#PROTEIN#Ras#P01306##;GTP#SIMPLE_MOLECULE#GTP#S01856## inside COMPLEX Complex_br_(Ras/GTP) Long Name: MEK Synonym: MAPK/ERK kinase Accession: P01312 inside PROTEIN p27 Long Name: ERK Synonym: Estrogen Regulated Kinase Accession: P01300 inside PROTEIN p28 Long Name: ERK Synonym: Estrogen Regulated Kinase Accession: P01300 inside PROTEIN p28 Long Name: ERK Synonym: Estrogen Regulated Kinase Accession: P01300 inside PROTEIN p28 Long Name: Jnk Synonym: Jun kinase,c-Jun N-terminal Kinase Accession: P01336 inside PROTEIN p29 Long Name: Jnk Synonym: Jun kinase,c-Jun N-terminal Kinase Accession: P01336 inside PROTEIN p29 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05538 Heterodimer Member Info: rac#PROTEIN#rac#P01324##;GDP#SIMPLE_MOLECULE#GDP#S01855## inside COMPLEX Complex_br_(rac/GDP) Long Name: Long Name: cdc42 Synonym: Synonym not specified Accession: U05525 Heterodimer Member Info: GDP#SIMPLE_MOLECULE#GDP#S01855##;cdc42#PROTEIN#cdc42#P01333#Cell Division Cycle 42# inside COMPLEX Complex_br_(cdc42/GDP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05542 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S01856##;cdc42#PROTEIN#cdc42#P01333#Cell Division Cycle 42# inside COMPLEX Complex_br_(cdc42/GTP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05547 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S01856##;cdc42#PROTEIN#cdc42#P01333#Cell Division Cycle 42#;WASP#PROTEIN#WASP#P01334#Wiscott-Aldrich Syndrome Protein# inside COMPLEX Complex_br_(cdc42/GTP/_br_WASP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05541 Heterodimer Member Info: Pak#PROTEIN#Pak#P01319#p21-activated kinase#;GTP#SIMPLE_MOLECULE#GTP#S01856##;rac#PROTEIN#rac#P01324## inside COMPLEX Complex_br_(rac/GTP/_br_Pak) Long Name: Actin polymerization Synonym: Synonym not specified Accession: U02632 inside PHENOTYPE Actin polymerization Long Name: IP3 Synonym: Synonym not specified Accession: S01848 inside SIMPLE_MOLECULE IP3 Long Name: DAG Synonym: Synonym not specified Accession: S01850 inside SIMPLE_MOLECULE DAG Long Name: PKC theta Synonym: Protein Kinase C theta Accession: P01318 inside PROTEIN p31 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05531 Heterodimer Member Info: DAG#SIMPLE_MOLECULE#DAG#S01850##;PKC-theta#PROTEIN#PKC theta#P01318#Protein Kinase C theta# inside COMPLEX Complex_br_(DAG/PKC-theta) Long Name: Calmodulin Synonym: Synonym not specified Accession: P01305 inside PROTEIN p36 Long Name: NF-AT Synonym: Nuclear Factor of Activated T cells Accession: P01294 inside PROTEIN p35 Long Name: NF-AT Synonym: Nuclear Factor of Activated T cells Accession: P01294 inside PROTEIN p35 Long Name: Jnk Synonym: Jun kinase,c-Jun N-terminal Kinase Accession: P01336 inside PROTEIN p29 Long Name: NF-AT Synonym: Nuclear Factor of Activated T cells Accession: P01294 inside PROTEIN p35 Long Name: jun Synonym: Synonym not specified Accession: P01335 inside PROTEIN p38 Long Name: jun Synonym: Synonym not specified Accession: P01335 inside PROTEIN p38 Long Name: ATP Synonym: Synonym not specified Accession: S01851 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01854 inside SIMPLE_MOLECULE ADP Long Name: fos Synonym: c-fos Accession: P01309 inside PROTEIN p37 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05551 Heterodimer Member Info: fos#PROTEIN#fos#P01309#c-fos#;jun#PROTEIN#jun#P01335## inside COMPLEX Complex_br_(jun/fos) Long Name: TCR-responsive genes Synonym: Synonym not specified Accession: G01549 inside GENE gn1 Long Name: T cell proliferation Synonym: Synonym not specified Accession: U02630 inside PHENOTYPE T cell proliferation Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05527 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P01303#Growth factor receptor-bound protein 2#;SOS#PROTEIN#SOS#P01307#Son of Sevenless# inside COMPLEX Complex_br_(SOS/Grb2) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05545 Heterodimer Member Info: NF-kappa B#PROTEIN#NF-kappa B#P01298#NF-kB|Nuclear factor kappa B#;I kappa B#PROTEIN#I kappa B#P01323#IkB|inhibitor of NF-kappa B# inside COMPLEX Complex_br_(NF-kappa B/I kappa B) Long Name: I kappa B Synonym: IkB,inhibitor of NF-kappa B Accession: P01323 inside PROTEIN p43 Long Name: NF-kappa B Synonym: NF-kB,Nuclear factor kappa B Accession: P01298 inside PROTEIN p42 Long Name: NF-kappa B Synonym: NF-kB,Nuclear factor kappa B Accession: P01298 inside PROTEIN p42 Long Name: CD28 Synonym: Synonym not specified Accession: P01313 transmembrane PROTEIN p44 2 Long Name: PIP Synonym: Synonym not specified Accession: S01849 inside SIMPLE_MOLECULE PIP Long Name: PIP3 Synonym: Synonym not specified Accession: S01852 inside SIMPLE_MOLECULE PIP3 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05532 Heterodimer Member Info: PIP2#SIMPLE_MOLECULE#PIP2#S01853##;Akt#PROTEIN#Akt#P01332#PKB|Protein Kinase B# inside COMPLEX Complex_br_(PIP2/Akt) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05543 Heterodimer Member Info: PIP3#SIMPLE_MOLECULE#PIP3#S01852##;Akt#PROTEIN#Akt#P01332#PKB|Protein Kinase B# inside COMPLEX Complex_br_(PIP3/Akt) Long Name: B7 Synonym: Synonym not specified Accession: P01337 transmembrane PROTEIN p47 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05553 Heterodimer Member Info: CD28#PROTEIN#CD28#P01313##;B7#PROTEIN#B7#P01337## transmembrane COMPLEX Complex_br_(CD28/B7) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05549 Heterodimer Member Info: CD28#PROTEIN#CD28#P01313##;B7#PROTEIN#B7#P01337## transmembrane COMPLEX Complex_br_(CD28/B7) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05524 Heterodimer Member Info: TCR zeta#PROTEIN#TCR zeta#P01296#CD3 zeta|T cell receptor, zeta chain#;TCR Beta#PROTEIN#TCR Beta#P01299#T cell receptor, beta chain#;TCR alpha#PROTEIN#TCR alpha#P01301#T cell receptor alpha chain#;CD3 eta#PROTEIN#CD3 epsilon#P01302##;CD3 gamma#PROTEIN#CD3 gamma#P01317##;CD3 delta#PROTEIN#CD3 delta#P01326## transmembrane COMPLEX Complex_br_(CD3_br_gamma/TCR_br_alpha/_br_TCR_br_Beta/CD3_br_delta/_br_CD3_br_eta/TCR_br_zeta) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05534 Heterodimer Member Info: TCR zeta#PROTEIN#TCR zeta#P01296#CD3 zeta|T cell receptor, zeta chain#;TCR Beta#PROTEIN#TCR Beta#P01299#T cell receptor, beta chain#;TCR alpha#PROTEIN#TCR alpha#P01301#T cell receptor alpha chain#;CD3 eta#PROTEIN#CD3 epsilon#P01302##;MHC-antigen#PROTEIN#MHC-antigen#P01316#Major Histocompatibility Complex#;CD3 gamma#PROTEIN#CD3 gamma#P01317##;CD3 delta#PROTEIN#CD3 delta#P01326## transmembrane COMPLEX Complex_br_(TCR_br_Beta/MHC-antigen/_br_CD3_br_gamma/TCR_br_alpha/_br_CD3_br_eta/CD3_br_delta/_br_TCR_br_zeta) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05536 Heterodimer Member Info: TCR zeta#PROTEIN#TCR zeta#P01296#CD3 zeta|T cell receptor, zeta chain#;TCR Beta#PROTEIN#TCR Beta#P01299#T cell receptor, beta chain#;TCR alpha#PROTEIN#TCR alpha#P01301#T cell receptor alpha chain#;CD3 eta#PROTEIN#CD3 epsilon#P01302##;MHC-antigen#PROTEIN#MHC-antigen#P01316#Major Histocompatibility Complex#;CD3 gamma#PROTEIN#CD3 gamma#P01317##;CD3 delta#PROTEIN#CD3 delta#P01326## transmembrane COMPLEX Complex_br_(TCR_br_Beta/MHC-antigen/_br_TCR_br_alpha/CD3_br_gamma/_br_CD3_br_delta/CD3_br_eta/_br_TCR_br_zeta) Long Name: CD45 Synonym: Leukocyte common antigen Accession: P01329 transmembrane PROTEIN p1 2 Long Name: MHC-antigen Synonym: Major Histocompatibility Complex Accession: P01316 transmembrane PROTEIN p7 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05533 Heterodimer Member Info: TCR zeta#PROTEIN#TCR zeta#P01296#CD3 zeta|T cell receptor, zeta chain#;TCR Beta#PROTEIN#TCR Beta#P01299#T cell receptor, beta chain#;TCR alpha#PROTEIN#TCR alpha#P01301#T cell receptor alpha chain#;CD3 eta#PROTEIN#CD3 epsilon#P01302##;ZAP-70#PROTEIN#ZAP-70#P01308#Zeta-associated protein of 70 kD#;CD3 gamma#PROTEIN#CD3 gamma#P01317##;CD3 delta#PROTEIN#CD3 delta#P01326## transmembrane COMPLEX Complex_br_(TCR_br_Beta/CD3_br_gamma/_br_CD3_br_delta/CD3_br_eta/_br_TCR_br_zeta/ZAP-70/_br_TCR_br_alpha) Long Name: ZAP-70 Synonym: Zeta-associated protein of 70 kD Accession: P01308 inside PROTEIN p5 Long Name: LAT Synonym: Linker for Activation of T cells,pp36/38 Accession: P01325 transmembrane PROTEIN p13 Long Name: vav Synonym: Synonym not specified Accession: P01295 inside PROTEIN p15 Long Name: nck Synonym: Synonym not specified Accession: P01314 inside PROTEIN p19 Long Name: PLC-gamma Synonym: phospholipase c, gamma isoform Accession: P01320 inside PROTEIN p16 Long Name: MEK Synonym: MAPK/ERK kinase Accession: P01312 inside PROTEIN p27 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05546 Heterodimer Member Info: SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;LAT#PROTEIN#LAT#P01325#Linker for Activation of T cells|pp36/38#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc# transmembrane COMPLEX Complex_br_(LAT/Gads/_br_SLP-76) Long Name: Akt Synonym: PKB,Protein Kinase B Accession: P01332 inside PROTEIN p46 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05528 Heterodimer Member Info: TCR zeta#PROTEIN#TCR zeta#P01296#CD3 zeta|T cell receptor, zeta chain#;TCR Beta#PROTEIN#TCR Beta#P01299#T cell receptor, beta chain#;TCR alpha#PROTEIN#TCR alpha#P01301#T cell receptor alpha chain#;CD3 eta#PROTEIN#CD3 epsilon#P01302##;ZAP-70#PROTEIN#ZAP-70#P01308#Zeta-associated protein of 70 kD#;CD3 gamma#PROTEIN#CD3 gamma#P01317##;CD3 delta#PROTEIN#CD3 delta#P01326## transmembrane COMPLEX Complex_br_(CD3_br_gamma/TCR_br_Beta/_br_CD3_br_delta/CD3_br_eta/_br_TCR_br_zeta/ZAP-70/_br_TCR_br_alpha) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05535 Heterodimer Member Info: Grb2#PROTEIN#Grb2#P01303#Growth factor receptor-bound protein 2#;SOS#PROTEIN#SOS#P01307#Son of Sevenless#;PLC-gamma#PROTEIN#PLC-gamma#P01320#phospholipase c, gamma isoform#;SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;LAT#PROTEIN#LAT#P01325#Linker for Activation of T cells|pp36/38#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc# transmembrane COMPLEX Complex_br_(LAT/SLP-76/_br_Grb2/SOS/_br_Gads/PLC-gamma) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05544 Heterodimer Member Info: Ras#PROTEIN#Ras#P01306##;Raf#PROTEIN#Raf#P01311##;MEK#PROTEIN#MEK#P01312#MAPK/ERK kinase#;GTP#SIMPLE_MOLECULE#GTP#S01856## innerSurface COMPLEX Complex_br_(Ras/GTP/_br_Raf/MEK) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05529 Heterodimer Member Info: Calmodulin#PROTEIN#Calmodulin#P01305##;Ca++#ION#Ca++#U02631## inside COMPLEX Complex_br_(Calmodulin/Ca++/_br_Ca++) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05539 Heterodimer Member Info: PLC-gamma#PROTEIN#PLC-gamma#P01320#phospholipase c, gamma isoform#;SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;LAT#PROTEIN#LAT#P01325#Linker for Activation of T cells|pp36/38#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc# transmembrane COMPLEX Complex_br_(LAT/PLC-gamma/_br_Gads/SLP-76) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05537 Heterodimer Member Info: PLC-gamma#PROTEIN#PLC-gamma#P01320#phospholipase c, gamma isoform#;SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;LAT#PROTEIN#LAT#P01325#Linker for Activation of T cells|pp36/38#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc# transmembrane COMPLEX Complex_br_(LAT/PLC-gamma/_br_Gads/SLP-76) Long Name: PLC-gamma Synonym: phospholipase c, gamma isoform Accession: P01320 inside PROTEIN p16 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05552 Heterodimer Member Info: vav#PROTEIN#vav#P01295##;nck#PROTEIN#nck#P01314##;Pak#PROTEIN#Pak#P01319#p21-activated kinase#;SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;LAT#PROTEIN#LAT#P01325#Linker for Activation of T cells|pp36/38#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc#;WASP#PROTEIN#WASP#P01334#Wiscott-Aldrich Syndrome Protein# transmembrane COMPLEX Complex_br_(LAT/Pak/_br_Gads/SLP-76/_br_WASP/vav/_br_nck) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05523 Heterodimer Member Info: vav#PROTEIN#vav#P01295##;nck#PROTEIN#nck#P01314##;SLP-76#PROTEIN#SLP-76#P01321#SH2 domain-containing leukocyte protein of 76 kD#;LAT#PROTEIN#LAT#P01325#Linker for Activation of T cells|pp36/38#;Gads#PROTEIN#Gads#P01327#Grb2-related adaptor downstream of Shc# transmembrane COMPLEX Complex_br_(LAT/Gads/_br_SLP-76/vav/_br_nck) Long Name: Lck Synonym: Lymphocyte-specific c-src family protein tyrosine kinase Accession: P01310 inside PROTEIN p12 Long Name: Lck Synonym: Lymphocyte-specific c-src family protein tyrosine kinase Accession: P01310 inside PROTEIN p12 Long Name: ATP Synonym: Synonym not specified Accession: S01851 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01854 inside SIMPLE_MOLECULE ADP Long Name: Pi Synonym: Synonym not specified Accession: S01847 inside SIMPLE_MOLECULE Pi Long Name: WASP Synonym: Wiscott-Aldrich Syndrome Protein Accession: P01334 inside PROTEIN p20 Long Name: Pak Synonym: p21-activated kinase Accession: P01319 inside PROTEIN p21 Long Name: ZAP-70 Synonym: Zeta-associated protein of 70 kD Accession: P01308 inside PROTEIN p5 Long Name: Raf Synonym: Synonym not specified Accession: P01311 inside PROTEIN p25 Long Name: GTP Synonym: Synonym not specified Accession: S01856 inside SIMPLE_MOLECULE GTP Long Name: GDP Synonym: Synonym not specified Accession: S01855 inside SIMPLE_MOLECULE GDP Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05526 Heterodimer Member Info: Ras#PROTEIN#Ras#P01306##;Raf#PROTEIN#Raf#P01311##;GTP#SIMPLE_MOLECULE#GTP#S01856## inside COMPLEX Complex_br_(Ras/GTP/_br_Raf) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05540 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S01856##;rac#PROTEIN#rac#P01324## inside COMPLEX Complex_br_(rac/GTP) Long Name: PIP2 Synonym: Synonym not specified Accession: S01853 inside SIMPLE_MOLECULE PIP2 Long Name: CRAC Synonym: Synonym not specified Accession: P01328 transmembrane PROTEIN p33 Long Name: Ca++ Synonym: Synonym not specified Accession: U02631 inside ION Ca++ Long Name: Calcineurin Synonym: Synonym not specified Accession: P01315 inside PROTEIN p34 Long Name: MEKK Synonym: MAP kinase kinase kinase,MEK kinase Accession: P01297 inside PROTEIN p39 Long Name: PI3K Synonym: Phosphatidyl Inositol (3,4,5) kinase Accession: P01322 inside PROTEIN p45 Long Name: Lck Synonym: Lymphocyte-specific c-src family protein tyrosine kinase Accession: P01310 inside PROTEIN p12 Long Name: Ca++ Synonym: Synonym not specified Accession: U02631 inside ION Ca++ Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05526 Heterodimer Member Info: Ras#PROTEIN#Ras#P01306##;Raf#PROTEIN#Raf#P01311##;GTP#SIMPLE_MOLECULE#GTP#S01856## innerSurface COMPLEX Complex_br_(Ras/GTP/_br_Raf) inside RNA rn1 Long Name: IKK Synonym: Inhibitor of NF-kappa B kinase Accession: P01330 inside PROTEIN p41 Long Name: IP3R Synonym: IP3 Receptor Accession: P01331 transmembrane PROTEIN p40 Long Name: Ca++ Synonym: Synonym not specified Accession: U02631 inside ION Ca++ STATE_TRANSITION 0.6198134380698546,2.3846261747806352E-4 a19 a18 a34 a25 STATE_TRANSITION 0.4120689655172418,-8.881784197001252E-16 0.6155172413793095,-8.881784197001252E-16 a18 a29 a3 a30 a20 STATE_TRANSITION 0.344890510948906,0.0 0.556569343065693,0.0 a28 a31 a19 a33 a26 STATE_TRANSITION a4 a275 a667 STATE_TRANSITION 0.3380604961501903,0.0011534003531572523 0.6475013758944581,9.348576196703817E-4 a388 a390 a389 a391 a682 HETERODIMER_ASSOCIATION 0.3719254302569297,0.3434711861927693 a389 a376 a397 STATE_TRANSITION a379 a403 a692 STATE_TRANSITION 0.3787165465541582,-0.0016115597725701036 0.6397047284491602,-0.0027221477806342875 a435 a433 a434 a438 a764 STATE_TRANSITION 0.390140615840358,0.004861316248611303 0.6453967109948482,-9.714586859352892E-4 a436 a432 a437 a439 a764 HETERODIMER_ASSOCIATION 0.4256016089367698,0.3337025458238325 a434 a294 a454 HETERODIMER_ASSOCIATION 0.46656104187168523,0.3159805763378474 a437 a293 a452 HETERODIMER_ASSOCIATION 0.32777715836027,0.27806890400267736 a471 a473 a476 STATE_TRANSITION a478 a479 a522 STATE_TRANSITION a485 a487 a699 STATE_TRANSITION 0.1805257979356476,0.022810778146819644 0.6658673131471886,0.019470787332863893 a494 a486 a498 a487 STATE_TRANSITION 0.33995204451625227,-2.2961063686821603E-4 0.5985245468253737,4.947188944788294E-4 a500 a502 a501 a503 a405 HETERODIMER_ASSOCIATION 0.34967176170879455,0.27380952380952195 a499 a501 a506 a404 STATE_TRANSITION a407 a406 a563 DISSOCIATION 0.22932187842585705,0.2349150949728056 a525 a526 a527 a524 STATE_TRANSITION a523 a524 a476 STATE_TRANSITION a493 a482 STATE_TRANSITION 0.36124134746881253,-2.4168728313256338E-4 0.6422530405574065,7.300927107194433E-4 a546 a549 a547 a551 a765 STATE_TRANSITION 0.25086222604876696,-0.0010637916941422798 0.5681630305731105,0.002367308090813758 a547 a550 a548 a552 a765 HETERODIMER_ASSOCIATION -0.012358742691233715,0.5527292788698475 a547 a559 a560 STATE_TRANSITION a562 a563 a560 a561 HETERODIMER_ASSOCIATION 0.40248094059219497,0.35601535351703006 a567 a566 a575 STATE_TRANSITION 0.36065573770495263,1.3322676295501878E-15 0.6338797814207844,4.440892098500626E-16 a575 a541 a579 a542 a540 TRANSPORT a406 a405 TRANSPORT a527 a533 TRANSPORT a486 a495 TRANSPORT a403 a404 HETERODIMER_ASSOCIATION 0.3682764759134758,0.45636755525722084 a2 a601 a615 STATE_TRANSITION 0.30387871538383493,4.759556779130314E-4 0.6887430965501391,-0.001330469229139375 a615 a630 a629 a631 a3 STATE_TRANSITION a632 a25 HETERODIMER_ASSOCIATION 0.26205453396944384,0.35061836798647894 a629 a633 a648 STATE_TRANSITION 0.29543992061681834,6.148274172677048E-4 0.6666788094102447,-0.002218569862353359 a648 a668 a667 a669 a653 a649 HETERODIMER_ASSOCIATION 0.5147794573980207,0.0022389220825802525 -0.0024620972395035245,0.3560561345987736 a275 a302 a305 a511 a682 HETERODIMER_ASSOCIATION 0.15902388913046694,0.4655806515041263 a397 a400 a691 DISSOCIATION 0.6190752052193425,0.007544605683680317 a691 a692 a693 a694 TRANSPORT 0.21972616903966125,3.22239882741826E-5 a480 a493 a479 HETERODIMER_ASSOCIATION 0.39139425919047,0.2727662825101129 a482 a488 a699 STATE_TRANSITION a514 a516 a470 STATE_TRANSITION 0.24504409255833393,-0.0012011965321399032 a517 a522 a516 STATE_TRANSITION 0.397058823529413,0.0 0.617647058823529,0.0 a720 a722 a717 a721 a373 DISSOCIATION 0.48568860440917305,0.012927697613317246 a717 a729 a725 DISSOCIATION 0.4008886067914901,0.3628795091505381 a469 a471 a470 a725 HETERODIMER_ASSOCIATION 0.4613218698425392,0.5364646059146168 a559 a548 a561 HETERODIMER_ASSOCIATION 0.20377780767959308,-0.005607247782486446 -0.0027026876396281097,0.5169480984287063 a729 a425 a422 a421 a278 a743 DISSOCIATION 0.3308181602154008,-0.0013017305097218212 0.409327769400857,0.1369755714670906 a743 a764 a294 a293 STATE_TRANSITION a537 a765 a579 MODULATION a454 a455 MODULATION a452 a455 STATE_TRANSITION sa215 a513 a434 TRANSCRIPTION a507 sa216 a506 a495 a533 MODULATION sa216 a508