Panther Pathway: P04394 http://www.pdg.cnb.uam.es/UniPub/iHOP/gs/125698.html 4.0 s10 SIMPLE_MOLECULE GTP s10 PROTEIN p8 s24 PROTEIN p8 s26 SIMPLE_MOLECULE GDP s26 PROTEIN p3 s26 PROTEIN p2 s27 PROTEIN p2 s40 PROTEIN p11 s40 ION Ca_super_2+ s27 PROTEIN p3 s24 PROTEIN p3 s24 SIMPLE_MOLECULE GDP s26 PROTEIN p8 SQUARE SQUARE SQUARE SQUARE SQUARE_CLOSEUP_SOUTH inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive SRI International Endoplasmic Reticulum Secretory Vesicle Adenohypophysis cells (anterior pituitary) Parvocellular cells in Paraventricular Nucleus of Hypothalamus (release of TRH from Median Eminence) Long Name: ProTRH (Pro Thyrotropin-releasing Hormone) Synonym: Pro Thyrotropin-releasing Hormone Accession: P04586 inside PROTEIN p1 Long Name: TRH Synonym: Synonym not specified Accession: P04585 inside PROTEIN p2 Long Name: GDP Synonym: Synonym not specified Accession: S04856 inside SIMPLE_MOLECULE GDP Long Name: GTP Synonym: Synonym not specified Accession: S04853 inside SIMPLE_MOLECULE GTP Long Name: DAG Synonym: Synonym not specified Accession: S04855 inside SIMPLE_MOLECULE DAG Long Name: Long name not specified Synonym: Synonym not specified Accession: U05558 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S04853##;G-Protein#PROTEIN#G-Protein#P04584## inside COMPLEX Complex_br_(GTP/G-Protein) Long Name: PIP2 Synonym: Synonym not specified Accession: S04852 inside SIMPLE_MOLECULE PIP2 Long Name: IP3 Synonym: Synonym not specified Accession: S04854 inside SIMPLE_MOLECULE IP_sub_3 Long Name: SNARE COMPLEX Synonym: Synonym not specified Accession: P04582 transmembrane PROTEIN p11 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05554 Heterodimer Member Info: TRH Receptor#PROTEIN#TRH Receptor#P04580#TRH Receptor 1|TRH Receptor 2|Thyrotropin-releasing hormone Receptor#;G-Protein#PROTEIN#G-Protein#P04584##;GDP#SIMPLE_MOLECULE#GDP#S04856## transmembrane COMPLEX Complex_br_(GDP/G-Protein/_br_TRH Receptor) Long Name: Long name not specified Synonym: Synonym not specified Accession: U05557 Heterodimer Member Info: TRH Receptor#PROTEIN#TRH Receptor#P04580#TRH Receptor 1|TRH Receptor 2|Thyrotropin-releasing hormone Receptor#;G-Protein#PROTEIN#G-Protein#P04584##;TRH#PROTEIN#TRH#P04585##;GDP#SIMPLE_MOLECULE#GDP#S04856## transmembrane COMPLEX Complex_br_(GDP/G-Protein/_br_TRH Receptor/TRH) Long Name: Long name not specified Synonym: Synonym not specified Accession: U05555 Heterodimer Member Info: TRH Receptor#PROTEIN#TRH Receptor#P04580#TRH Receptor 1|TRH Receptor 2|Thyrotropin-releasing hormone Receptor#;TRH#PROTEIN#TRH#P04585## transmembrane COMPLEX Complex_br_(TRH Receptor/TRH) Long Name: TRH Synonym: Synonym not specified Accession: P04585 inside PROTEIN p2 Long Name: PLC Synonym: Synonym not specified Accession: P04581 inside PROTEIN p6 Long Name: Ca2+ Synonym: Synonym not specified Accession: U05559 inside ION Ca_super_2+ Long Name: PKC Synonym: protein kinase C Accession: P04583 inside PROTEIN p9 Long Name: Thyrotropin Synonym: TSH,Thyroid Stimulating Hormone Accession: P04588 inside PROTEIN p5 Long Name: Thyrotropin Synonym: TSH,Thyroid Stimulating Hormone Accession: P04588 inside PROTEIN p5 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05556 Heterodimer Member Info: Ca2+#ION#Ca2+#U05559##;SNARE COMPLEX#PROTEIN#SNARE COMPLEX#P04582## transmembrane COMPLEX Complex_br_(SNARE COMPLEX/Ca_super_2+) Long Name: Thyroid hormone release Synonym: Synonym not specified Accession: U05560 inside PHENOTYPE Thyroid hormone_br_release Long Name: Ca2+ channel Synonym: Synonym not specified Accession: P04587 transmembrane PROTEIN p10 Long Name: Ca2+ Synonym: Synonym not specified Accession: U05559 inside ION Ca_super_2+ DISSOCIATION 0.34451419408374484,0.32065833561867585 a18 a19 a10 a9 STATE_TRANSITION a20 a21 a10 STATE_TRANSITION a17 a15 a21 TRANSPORT 0.6985841836734694,0.0 a16 a14 a15 STATE_TRANSITION a8 a9 a11 UNKNOWN_TRANSITION a1 a35 TRANSPORT 0.5441363667459664,-0.0010855406864995754 a35 a2 a34 HETERODIMER_ASSOCIATION -0.3083856311377069,-5.481189453986346E-4 0.0015487042091315573,0.26716777503933953 a2 a37 a40 DISSOCIATION 0.2339495472781712,8.371303456877754E-4 0.7054058519108901,-0.0010811910450239104 0.5015984782778697,0.12015556675644934 a40 a7 a41 a11 a6 TRANSPORT a46 a45 a51 HETERODIMER_ASSOCIATION 0.7731357052254673,7.59254976589574E-4 0.5074018774109667,0.3338151972807095 a14 a43 a51 PHYSICAL_STIMULATION a45 a52