Panther Pathway: P00055 bZip General Transcription Factors for RNA Polymerase II The basic-leucine zipper (bZIP) transcription factors of eukaryotic are proteins that contain a basic region mediating sequence-specific DNA-binding followed by a leucine zipper region required for dimerization. This pathway represent the CRE-BP/ATF subfamily of bZIP. Medline=10364255 Medline=1496333 Medline=1876184 Medline=1956398 Medline=7615553 OMIM=189972 PMID: 10364255 PMID: 1496333 PMID: 1876184 PMID: 1956398 PMID: 7615553 4.0 Long Name: TATA box Promoter gene Synonym: Synonym not specified Accession: G01553 s173 GENE gn1 Long Name: elongating mRNA Synonym: Synonym not specified Accession: G01557 s173 RNA rn1 Long Name: RNA Synonym: Synonym not specified Accession: G01554 s181 RNA rn2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05584 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P01385#TATA box binding protein-associated factors#;TBP#PROTEIN#TBP#P01399#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# s170 COMPLEX Complex_br_(TBP-associated factors/TBP) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05585 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P01385#TATA box binding protein-associated factors#;TFIIA complex#PROTEIN#TFIIA#P01390#ALF|GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNITS|GTF2A1-like factor|MGC26254|TFIIA large subunit isoform ALF|TFIIA-alpha/beta-like factor#;TATA box Promoter#GENE#TATA box Promoter#G01556##;TBP#PROTEIN#TBP#P01399#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# s160 COMPLEX Complex_br_(TBP-associated factors/TBP/_br_TATA box Promoter/TFIIA complex) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05575 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P01385#TATA box binding protein-associated factors#;TFIIA complex#PROTEIN#TFIIA#P01390#ALF|GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNITS|GTF2A1-like factor|MGC26254|TFIIA large subunit isoform ALF|TFIIA-alpha/beta-like factor#;TFIIB#PROTEIN#TFIIB#P01397#GTF2B|RNA polymerase II transcription factor IIB|TF2B|general transcription factor IIB#;TATA box Promoter#GENE#TATA box Promoter#G01556##;TBP#PROTEIN#TBP#P01399#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# s161 COMPLEX Complex_br_(TBP-associated factors/TBP/_br_TATA box Promoter/TFIIB/_br_TFIIA complex) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05582 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P01385#TATA box binding protein-associated factors#;RNA Polymerase II#PROTEIN#RNA Polymerase II#P01388##;TFIIA complex#PROTEIN#TFIIA#P01390#ALF|GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNITS|GTF2A1-like factor|MGC26254|TFIIA large subunit isoform ALF|TFIIA-alpha/beta-like factor#;TFIIH complex#PROTEIN#TFIIH#P01392#GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 1|GTF2H 62-KD SUBUNIT|GTF2H1|TFIIH 62-KD SUBUNIT|TRANSCRIPTION FACTOR IIH 62-KD SUBUNIT#;TFIIF#PROTEIN#TFIIF#P01394#TF2F|TRANSCRIPTION FACTOR IIF#;TFIIE#PROTEIN#TFIIE#P01395#TF2E|TFIIE#;TFIIB#PROTEIN#TFIIB#P01397#GTF2B|RNA polymerase II transcription factor IIB|TF2B|general transcription factor IIB#;TATA box Promoter#GENE#TATA box Promoter#G01556##;TBP#PROTEIN#TBP#P01399#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# s168 COMPLEX Complex_br_(TATA box Promoter/TBP/_br_TBP-associated factors/TFIIA complex/_br_TFIIH complex/TFIIB/_br_RNA Polymerase II/TFIIF/_br_TFIIE) Long Name: CRE Synonym: Synonym not specified Accession: G01552 s170 GENE gn4 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05576 Heterodimer Member Info: CREB#PROTEIN#CREB#P01383#cAMP responsive element binding protein#;CBP/P300#PROTEIN#CBP/P300#P01387#CREB-binding protein# s168 COMPLEX Complex_br_(CREB/CBP/_br_P300) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05583 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P01385#TATA box binding protein-associated factors#;RNA Polymerase II#PROTEIN#RNA Polymerase II#P01388##;TFIIA complex#PROTEIN#TFIIA#P01390#ALF|GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNITS|GTF2A1-like factor|MGC26254|TFIIA large subunit isoform ALF|TFIIA-alpha/beta-like factor#;TFIIH complex#PROTEIN#TFIIH#P01392#GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 1|GTF2H 62-KD SUBUNIT|GTF2H1|TFIIH 62-KD SUBUNIT|TRANSCRIPTION FACTOR IIH 62-KD SUBUNIT#;TFIIF#PROTEIN#TFIIF#P01394#TF2F|TRANSCRIPTION FACTOR IIF#;TFIIB#PROTEIN#TFIIB#P01397#GTF2B|RNA polymerase II transcription factor IIB|TF2B|general transcription factor IIB#;TATA box Promoter#GENE#TATA box Promoter#G01556##;TBP#PROTEIN#TBP#P01399#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# s169 COMPLEX Complex_br_(TATA box Promoter/RNA Polymerase II/_br_TFIIF/TBP/_br_TBP-associated factors/TFIIH complex/_br_TFIIA complex/TFIIB) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05581 Heterodimer Member Info: CREB#PROTEIN#CREB#P01383#cAMP responsive element binding protein#;CBP/P300#PROTEIN#CBP/P300#P01387#CREB-binding protein# s169 COMPLEX Complex_br_(CBP/P300/_br_CREB) s41 PROTEIN p22 s41 PROTEIN p22 s43 PROTEIN p21 s43 PROTEIN p21 s44 PROTEIN p4 s44 PROTEIN p3 s60 PROTEIN p12 s60 PROTEIN p8 s100 PROTEIN p3 s100 PROTEIN p4 s55 PROTEIN p3 s55 PROTEIN p4 s55 GENE gn3 s55 PROTEIN p19 s59 PROTEIN p3 s59 PROTEIN p4 s59 GENE gn3 s59 PROTEIN p7 s59 PROTEIN p19 s77 GENE gn3 s77 PROTEIN p4 s77 PROTEIN p3 s77 PROTEIN p19 s77 PROTEIN p13 s77 PROTEIN p7 s77 PROTEIN p8 s77 PROTEIN p12 s77 PROTEIN p20 s113 PROTEIN p23 2 s113 PROTEIN p24 s91 GENE gn3 s91 PROTEIN p8 s91 PROTEIN p12 s91 PROTEIN p4 s91 PROTEIN p3 s91 PROTEIN p13 s91 PROTEIN p19 s91 PROTEIN p7 s118 PROTEIN p24 s118 PROTEIN p23 2 s125 PROTEIN p26 s125 PROTEIN p27 s127 GENE gn3 s127 GENE gn4 s152 PROTEIN p24 s152 PROTEIN p23 2 Long Name: CRE Synonym: Synonym not specified Accession: G01552 s152 GENE gn4 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05576 Heterodimer Member Info: CREB#PROTEIN#CREB#P01383#cAMP responsive element binding protein#;CBP/P300#PROTEIN#CBP/P300#P01387#CREB-binding protein# s160 COMPLEX Complex_br_(CREB/CBP/_br_P300) Long Name: CRE Synonym: Synonym not specified Accession: G01552 s156 GENE gn4 s156 PROTEIN p23 2 s156 PROTEIN p24 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05576 Heterodimer Member Info: CREB#PROTEIN#CREB#P01383#cAMP responsive element binding protein#;CBP/P300#PROTEIN#CBP/P300#P01387#CREB-binding protein# s161 COMPLEX Complex_br_(CREB/CBP/_br_P300) Long Name: CRE Synonym: Synonym not specified Accession: G01552 s162 GENE gn4 s162 PROTEIN p23 2 s162 PROTEIN p24 Long Name: CRE Synonym: Synonym not specified Accession: G01552 s113 GENE gn4 Long Name: RNA Polymerase II Synonym: Synonym not specified Accession: P01388 s170 PROTEIN p8 Long Name: TATA box Promoter gene Synonym: Synonym not specified Accession: G01553 s170 GENE gn1 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05574 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P01385#TATA box binding protein-associated factors#;TBP#PROTEIN#TBP#P01399#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# s173 COMPLEX Complex_br_(TBP/TBP-associated factors) s177 PROTEIN p3 s177 PROTEIN p4 Long Name: RNA Polymerase II Synonym: Synonym not specified Accession: P01388 s173 PROTEIN p8 Long Name: TATA box Promoter gene termination Synonym: Synonym not specified Accession: G01551 s181 GENE gn2 Long Name: RNA Polymerase II Synonym: Synonym not specified Accession: P01388 s181 PROTEIN p8 Long Name: TTF2 Synonym: TRANSCRIPTION TERMINATION FACTOR RNA POLYMERASE II,human factor 2 Accession: P01389 s181 PROTEIN p28 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05574 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P01385#TATA box binding protein-associated factors#;TBP#PROTEIN#TBP#P01399#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# s181 COMPLEX Complex_br_(TBP/TBP-associated factors) s185 PROTEIN p4 s185 PROTEIN p3 SQUARE_CLOSEUP_SOUTHEAST inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive active inactive inactive active inactive inactive active inactive inactive inactive inactive inactive active inactive inactive active active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active active active active active active inactive active inactive inactive inactive inactive inactive inactive active active active inactive active active inactive inactive Kretchmer Orna Avsian SRI International cytosol Long Name: TBP Synonym: GTF2D,GTF2D1,SCA17,TATA box binding protein,TFIID,spinocerebellar ataxia 17 Accession: P01399 inside PROTEIN p4 Long Name: TFIIF Synonym: TF2F,TRANSCRIPTION FACTOR IIF Accession: P01394 inside PROTEIN p12 Long Name: ATP Synonym: Synonym not specified Accession: S01865 inside SIMPLE_MOLECULE ATP Long Name: ADP Synonym: Synonym not specified Accession: S01870 inside SIMPLE_MOLECULE ADP Long Name: RNA Polymerase II Synonym: Synonym not specified Accession: P01388 inside PROTEIN p8 Long Name: RNA Polymerase II Synonym: Synonym not specified Accession: P01388 inside PROTEIN p8 Long Name: CTP Synonym: Synonym not specified Accession: S01867 inside SIMPLE_MOLECULE CTP Long Name: GTP Synonym: Synonym not specified Accession: S01868 inside SIMPLE_MOLECULE GTP Long Name: UTP Synonym: Synonym not specified Accession: S01866 inside SIMPLE_MOLECULE UTP Long Name: TBP-associated factors Synonym: TATA box binding protein-associated factors Accession: P01385 inside PROTEIN p3 Long Name: General transcription factor IIF, polypeptide 1, 74-KD Synonym: BTF4,GTF2F1,RAP74,TF2F1,TFIIF ALPHA,TRANSCRIPTION FACTOR IIF Accession: P01391 inside PROTEIN p16 Long Name: TFIIFbeta Synonym: BETA SUBUNIT,RAP30,TF2F2,TFIIF BETA,TRANSCRIPTION FACTOR IIF Accession: P01396 inside PROTEIN p18 Long Name: TFIIB Synonym: GTF2B,RNA polymerase II transcription factor IIB,TF2B,general transcription factor IIB Accession: P01397 inside PROTEIN p7 Long Name: TFIIE Synonym: TF2E,TFIIE Accession: P01395 inside PROTEIN p20 Long Name: Long Name: TFIIEbeta Synonym: Synonym not specified Accession: U05578 Heterodimer Member Info: TFIIEbeta#PROTEIN#TFIIEbeta#P01386#GENERAL TRANSCRIPTION FACTOR IIE|GTF2E2|POLYPEPTIDE 2|TF2E2|TFIIE BETA SUBUNIT|TRANSCRIPTION FACTOR IIE BETA SUBUNIT# inside COMPLEX Complex_br_(TFIIE_beta/TFIIE_beta) Long Name: Long Name: TFIIEalpha Synonym: Synonym not specified Accession: U05579 Heterodimer Member Info: TFIIEalpha#PROTEIN#TFIIEalpha#P01398#ALPHA SUBUNIT|GENERAL TRANSCRIPTION FACTOR IIE|GTF2E1|POLYPEPTIDE 1|TF2E1|TFIIE|TRANSCRIPTION FACTOR IIE ALPHA SUBUNIT# inside COMPLEX Complex_br_(TFIIE_alpha_/TFIIE_alpha_) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05574 Heterodimer Member Info: TBP-associated factors#PROTEIN#TBP-associated factors#P01385#TATA box binding protein-associated factors#;TBP#PROTEIN#TBP#P01399#GTF2D|GTF2D1|SCA17|TATA box binding protein|TFIID|spinocerebellar ataxia 17# inside COMPLEX Complex_br_(TBP/TBP-associated factors) Long Name: TATA box Promoter gene termination Synonym: Synonym not specified Accession: G01551 inside GENE gn2 Long Name: mRNA Synonym: Synonym not specified Accession: G01555 inside RNA rn3 Long Name: TFIIH Synonym: GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 1,GTF2H 62-KD SUBUNIT,GTF2H1,TFIIH 62-KD SUBUNIT,TRANSCRIPTION FACTOR IIH 62-KD SUBUNIT Accession: P01392 inside PROTEIN p13 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05580 Heterodimer Member Info: RNA Polymerase II#PROTEIN#RNA Polymerase II#P01388##;TFIIF#PROTEIN#TFIIF#P01394#TF2F|TRANSCRIPTION FACTOR IIF# inside COMPLEX Complex_br_(TFIIF/RNA Polymerase II) Long Name: TFIIA Synonym: ALF,GENERAL TRANSCRIPTION FACTOR IIA GAMMA SUBUNITS,GTF2A1-like factor,MGC26254,TFIIA large subunit isoform ALF,TFIIA-alpha/beta-like factor Accession: P01390 inside PROTEIN p19 Long Name: CREB Synonym: cAMP responsive element binding protein Accession: P01383 inside PROTEIN p23 Long Name: CREB Synonym: cAMP responsive element binding protein Accession: P01383 inside PROTEIN p23 Long Name: CREB Synonym: cAMP responsive element binding protein Accession: P01383 inside PROTEIN p23 2 Long Name: cAMP Synonym: Synonym not specified Accession: S01869 inside SIMPLE_MOLECULE cAMP Long Name: Protein Kinase A Synonym: protein kinase A Accession: P01384 inside PROTEIN p25 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05581 Heterodimer Member Info: CREB#PROTEIN#CREB#P01383#cAMP responsive element binding protein#;CBP/P300#PROTEIN#CBP/P300#P01387#CREB-binding protein# inside COMPLEX Complex_br_(CBP/P300/_br_CREB) Long Name: Receptor Synonym: Synonym not specified Accession: P01400 transmembrane PROTEIN p26 Long Name: hormone Synonym: Synonym not specified Accession: P01393 inside PROTEIN p27 Long Name: TTF2 Synonym: TRANSCRIPTION TERMINATION FACTOR RNA POLYMERASE II,human factor 2 Accession: P01389 inside PROTEIN p28 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05573 Heterodimer Member Info: hormone#PROTEIN#hormone#P01393##;Receptor#PROTEIN#Receptor#P01400## transmembrane COMPLEX Complex_br_(Receptor/hormone) Long Name: CBP/P300 Synonym: CREB-binding protein Accession: P01387 inside PROTEIN p24 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05577 Heterodimer Member Info: CRE#GENE#CRE#G01552##;TATA box Promoter#GENE#TATA box Promoter#G01556## inside COMPLEX Complex_br_(CRE/TATA box Promoter) inside COMPLEX s160 inside COMPLEX s161 inside COMPLEX s168 inside COMPLEX s169 inside COMPLEX s170 inside COMPLEX s173 inside COMPLEX s181 HETERODIMER_ASSOCIATION 0.33709016393443036,0.3333954297069113 a84 a86 a42 HETERODIMER_ASSOCIATION 0.2904239672219191,0.4199866926587843 a18 a19 a106 HETERODIMER_ASSOCIATION 0.275079379082543,0.4510797296908433 a113 a114 a112 STATE_TRANSITION 0.34277903958076195,-0.013729157021376892 csa20 a24 csa24 HETERODIMER_ASSOCIATION 0.34056022823504684,0.29508587590130286 a29 a42 a148 HETERODIMER_ASSOCIATION 0.0015705365016132067,0.38213174793765736 csa24 a148 a112 a44 csa25 STATE_TRANSITION 0.28875751670245187,0.0017569247802846633 0.5776471765813813,-0.005698393145310732 csa25 a66 csa26 a67 a223 STATE_TRANSITION 0.482253835100094,0.0027991181963633593 csa26 csa27 a220 a221 a219 STATE_TRANSITION 0.57338243029983,-0.00263019463441605 0.8440189374013585,-0.0038716465018513446 csa27 a81 a80 a79 a78 csa28 STATE_TRANSITION csa28 a292 csa29 STATE_TRANSITION 0.29724492080199294,-0.00926793316764396 0.7206540949307647,1.5739052812335785E-4 a224 a225 a227 a226 a244 STATE_TRANSITION a227 a237 HETERODIMER_ASSOCIATION 0.47661856807381486,0.3608135392290641 a291 a290 a299 STATE_TRANSITION a300 a243 a299 HETERODIMER_ASSOCIATION 0.7175696365100617,0.307593646609881 a238 a237 a305 HETERODIMER_ASSOCIATION 0.763261856463064,0.003765173441946601 -71.98773810351301,22.522122739403727 a306 a106 a305 a87 csa20 STATE_TRANSITION a307 a244 a243 STATE_TRANSITION csa29 a131 a130 a133 a132