Diagram of metabolism and activity of Vitamin D free text=Chapters 2,3,4,5,6,8,13,14 4.0 s23 SIMPLE_MOLECULE 1,25-dihydroxyvitamin D s23 PROTEIN p5 s24 SIMPLE_MOLECULE 1,25-dihydroxyvitamin D s24 PROTEIN p5 s33 PROTEIN p6 s33 PROTEIN p5 s33 SIMPLE_MOLECULE 1,25-dihydroxyvitamin D s55 PROTEIN p9 s55 SIMPLE_MOLECULE 1,25-dihydroxyvitamin D SQUARE SQUARE SQUARE SQUARE OVAL OVAL active active active inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Vitamin D Receptor Retinoid X Receptor Ferridoxin Ferridoxin Reductase Vitamin D 24-hydroxylase Vitamin D 1_alpha_-hydroxylase Nucleus Cell Mitochondrion Skin Liver Kidney Long Name: 1,25-dihydroxyvitamin D Synonym: Synonym not specified Accession: S04864 inside SIMPLE_MOLECULE 1,25-dihydroxyvitamin D Long Name: 1,25-dihydroxyvitamin D Synonym: Synonym not specified Accession: S04864 inside SIMPLE_MOLECULE 1,25-dihydroxyvitamin D Long Name: O2 Synonym: Synonym not specified Accession: U05599 inside ION O_sub_2 Long Name: H2O Synonym: Synonym not specified Accession: U05602 inside ION H_sub_2O Long Name: NADPH Synonym: Synonym not specified Accession: U05605 inside ION NADPH Long Name: NADP+ Synonym: Synonym not specified Accession: U05604 inside ION NADP+ Long Name: 25-hydroxy-vitamin D Synonym: Synonym not specified Accession: S04868 inside SIMPLE_MOLECULE 25-hydroxy-vitamin D Long Name: Vitamin D Receptor Synonym: Synonym not specified Accession: P04606 inside PROTEIN p5 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05595 Heterodimer Member Info: 1,25-dihydroxyvitamin D#SIMPLE_MOLECULE#1,25-dihydroxyvitamin D#S04864##;VDR#PROTEIN#Vitamin D Receptor#P04606## inside COMPLEX Complex_br_(1,25-dihydroxyvitamin D/Vitamin D_br_Receptor) Long Name: Long name not specified Synonym: Synonym not specified Accession: U05597 Heterodimer Member Info: 1,25-dihydroxyvitamin D#SIMPLE_MOLECULE#1,25-dihydroxyvitamin D#S04864##;VDR#PROTEIN#Vitamin D Receptor#P04606## inside COMPLEX Complex_br_(1,25-dihydroxyvitamin D/Vitamin D_br_Receptor) Long Name: Retinoid X Receptor, Alpha Synonym: Synonym not specified Accession: P04602 inside PROTEIN p6 Long Name: Ferredoxin Synonym: ADX,FDX Accession: P04607 inside PROTEIN p3 Long Name: Ferredoxin Reductase Synonym: ADXR,adrenodoxin reductase Accession: P04604 inside PROTEIN p4 Long Name: Vitamin D 24-Hydroxylase Synonym: CP24,CYP24,CYP42A1,cytochrome P450 24A1 Accession: P04608 inside PROTEIN p2 Long Name: Vitamin D 1-alpha-hydroxylase Synonym: CYP1,CYP27B1,P450c1,VDDR Accession: P04603 inside PROTEIN p1 Long Name: Differentiation Synonym: Synonym not specified Accession: U05600 inside PHENOTYPE Differentiation Long Name: 24-Hydroxylase Synonym: CP24,CYP24,CYP42A1,cytochrome P450 24A1 Accession: G04688 inside GENE gn1 Long Name: Growth Inhibition Synonym: Synonym not specified Accession: U05601 inside PHENOTYPE Growth Inhibition Long Name: Long name not specified Synonym: Synonym not specified Accession: U05598 Heterodimer Member Info: RXR#PROTEIN#Retinoid X Receptor, Alpha#P04602##;1,25-dihydroxyvitamin D#SIMPLE_MOLECULE#1,25-dihydroxyvitamin D#S04864##;VDR#PROTEIN#Vitamin D Receptor#P04606## inside COMPLEX Complex_br_(RXR/VDR/_br_1,25-dihydroxyvitamin D) Long Name: 25-hydroxyvitamin D Synonym: Synonym not specified Accession: S04861 inside SIMPLE_MOLECULE 25-hydroxyvitamin D Long Name: Vitamin D3 Synonym: Synonym not specified Accession: S04867 inside SIMPLE_MOLECULE Vitamin D3 Long Name: 25-hydroxy-vitamin D Synonym: Synonym not specified Accession: S04868 inside SIMPLE_MOLECULE 25-hydroxy-vitamin D Long Name: 25-hydroxy-vitamin D Synonym: Synonym not specified Accession: S04868 inside SIMPLE_MOLECULE 25-hydroxy-vitamin D Long Name: 1,25-dihydroxyvitamin D Synonym: Synonym not specified Accession: S04864 inside SIMPLE_MOLECULE 1,25-dihydroxyvitamin D Long Name: Vitamin D 1-alpha-hydroxylase Synonym: CYP1,CYP27B1,P450c1,VDDR Accession: P04603 inside PROTEIN p1 Long Name: Vitamin D 25-Hydroxylase Synonym: CYP27A1,cytochrome P450 27A1 Accession: P04601 inside PROTEIN p7 Long Name: O2 Synonym: Synonym not specified Accession: U05599 inside ION O_sub_2 Long Name: H2O Synonym: Synonym not specified Accession: U05602 inside ION H_sub_2O Long Name: NADP+ Synonym: Synonym not specified Accession: U05604 inside ION NADP+ Long Name: NADPH Synonym: Synonym not specified Accession: U05605 inside ION NADPH Long Name: 25-hydroxy-vitamin D3 Synonym: Synonym not specified Accession: S04866 inside SIMPLE_MOLECULE 25-hydroxy-vitamin D_sub_3 Long Name: Vitamin D3 Synonym: Synonym not specified Accession: S04867 inside SIMPLE_MOLECULE Vitamin D_sub_3 Long Name: Pre-Vitamin D3 Synonym: Synonym not specified Accession: S04869 inside SIMPLE_MOLECULE Pre-Vitamin D_sub_3 Long Name: 1,25-dihydroxyvitamin D3 Synonym: Synonym not specified Accession: S04863 inside SIMPLE_MOLECULE 1,25-dihydroxyvitamin D_sub_3 Long Name: 1,24,25-hydroxyvitamin D3 Synonym: Synonym not specified Accession: S04865 inside SIMPLE_MOLECULE 1,24,25-hydroxyvitamin D_sub_3 Long Name: Vitamin D binding protein Synonym: GC,VDBG,VDBP Accession: P04600 inside PROTEIN p9 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05596 Heterodimer Member Info: DBP#PROTEIN#Vitamin D binding protein#P04600#GC|VDBG|VDBP#;1,25-dihydroxyvitamin D#SIMPLE_MOLECULE#1,25-dihydroxyvitamin D#S04864## inside COMPLEX Complex_br_(DBP/1,25-dihydroxyvitamin D) Long Name: Vitamin D response element containing genes Synonym: Synonym not specified Accession: G04687 inside GENE gn2 Long Name: cytochrome P450 reductase Synonym: CYPOR,P450 (cytochrome) oxidoreductase,POR Accession: P04605 inside PROTEIN p8 inside RNA rn1 inside RNA rn2 inside UNKNOWN UV light TRANSPORT 0.3333333333333332,-8.326672684688674E-17 0.6666666666666663,-1.942890293094024E-16 a2 a3 TRANSPORT 0.33126984431198947,-3.194255450766903E-5 0.665634922155995,-1.597127725405656E-5 a1 a4 TRANSPORT 0.33333333333333326,0.0 0.6666666666666665,0.0 a4 a5 STATE_TRANSITION 0.33333333333333326,-2.220446049250313E-16 0.6666666666666665,-6.661338147750939E-16 a5 a11 a7 a12 a9 STATE_TRANSITION 0.33333333333333304,2.4424906541753444E-15 0.6666666666666661,5.551115123125783E-15 a7 a13 a8 a14 a10 STATE_TRANSITION a15 a9 a17 STATE_TRANSITION 0.3333333333333366,-2.6645352591003757E-15 0.6666666666666696,-1.7763568394002505E-15 a16 a10 a17 STATE_TRANSITION 0.33333333333334103,0.0 0.6666666666666679,-1.7763568394002505E-15 a19 a20 a17 a21 a18 HETERODIMER_ASSOCIATION 0.4169839222634065,0.034049092836268 0.8339678445268132,0.068098185672536 0.33333333333333304,-3.3306690738754696E-16 0.6666666666666679,1.1102230246251565E-16 0.33333333333333215,0.0 0.666666666666667,0.0 0.3514768038970084,0.36128987083184416 a23 a3 a27 TRANSPORT 0.3333333333333335,4.440892098500626E-16 0.6666666666666679,4.440892098500626E-16 a27 a28 HETERODIMER_ASSOCIATION 0.48472037317340533,-0.112593244502456 -0.16264060027698513,0.5455563850750895 a29 a28 a39 STATE_TRANSITION 0.33333333333333304,0.0 0.6666666666666661,1.6653345369377348E-16 a41 a42 sa53 TRANSPORT 0.3333333333333335,-2.220446049250313E-16 0.666666666666667,-6.661338147750939E-16 a42 a44 STATE_TRANSITION 0.3096718645364973,0.011448069134858407 0.6193437290729928,0.022896138269713262 a44 a53 a50 a45 a51 a52 a49 a54 STATE_TRANSITION 0.22989872302950243,-0.0011889035667107528 0.5632320563628357,-0.0011889035667107528 a46 a47 a48 TRANSPORT 0.3333333333333336,-2.220446049250313E-16 0.6666666666666667,-6.661338147750939E-16 a47 a2 TRANSPORT 0.34665445724292,0.010050283547801665 0.67332722862146,0.005025141773900656 a45 a46 TRANSPORT 0.32700941743320056,0.02420061322820599 0.6627244853263259,0.012921594393345615 a45 a1 HETERODIMER_ASSOCIATION 0.37527541076968607,0.055681855403301395 0.3333333333333337,0.33333333333333304 a55 a47 a63 TRANSPORT 0.33333333333333304,-2.220446049250313E-16 0.6666666666666663,-2.220446049250313E-16 a7 a3 TRANSCRIPTION a35 sa51 a39 TRANSLATION sa51 a16 TRANSCRIPTION a40 sa52 a39 MODULATION sa52 a34 MODULATION sa52 a33