Panther Pathway: P00058 Protein-coding genes contain introns which must be removed from pre-mRNAs to produce mRNAs for translation into proteins. Introns contain conserved splicing signals which ensure fidelity of splicing. Introns are removed in a large complex. The major splicing components are the U1, U2, U4/U6 and U5snRNPs (small nuclear ribonucleoprotein particles). Medline=11607023 Medline=14681577 Medline=8266100 Medline=8791582 OMIM=1411506 PMID: 11607023 PMID: 14681577 PMID: 8266100 PMID: 8791582 4.0 Long Name: Exon-1 Synonym: Synonym not specified Accession: G01562 s91 RNA rn1 Long Name: intron Synonym: Synonym not specified Accession: G01560 s91 RNA rn2 Long Name: Exon-2 Synonym: Synonym not specified Accession: G01561 s91 RNA rn3 s71 RNA rn1 s71 RNA rn2 s71 RNA rn3 s16 PROTEIN p5 s16 PROTEIN p3 s93 RNA rn2 s93 PROTEIN p2 s93 PROTEIN p4 s93 PROTEIN p5 s92 RNA rn3 s92 RNA rn1 s32 PROTEIN p8 s32 PROTEIN p9 s34 PROTEIN p3 s34 PROTEIN p5 s79 PROTEIN p5 s79 PROTEIN p3 s79 PROTEIN p2 s79 PROTEIN p4 s79 PROTEIN p1 s91 PROTEIN p4 s91 PROTEIN p2 s91 PROTEIN p5 s58 RNA rn1 s58 RNA rn2 s67 RNA rn2 s67 RNA rn3 s54 PROTEIN p9 s56 PROTEIN p8 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05642 Heterodimer Member Info: U2AF65#PROTEIN#U2AF65#P01475#U2AF65-ASSOCIATED PROTEIN|UAP65#;U2AF35#PROTEIN#U2AF35#P01477#U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35-KD SUBUNIT|U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1|U2AF1|U2AF35|splicing factor U2AF 35kDa subunit# s67 COMPLEX Complex_br_(U2AF35/U2AF65) s54 PROTEIN p8 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05642 Heterodimer Member Info: U2AF65#PROTEIN#U2AF65#P01475#U2AF65-ASSOCIATED PROTEIN|UAP65#;U2AF35#PROTEIN#U2AF35#P01477#U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35-KD SUBUNIT|U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1|U2AF1|U2AF35|splicing factor U2AF 35kDa subunit# s71 COMPLEX Complex_br_(U2AF35/U2AF65) s56 PROTEIN p9 s58 RNA rn3 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05642 Heterodimer Member Info: U2AF65#PROTEIN#U2AF65#P01475#U2AF65-ASSOCIATED PROTEIN|UAP65#;U2AF35#PROTEIN#U2AF35#P01477#U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35-KD SUBUNIT|U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1|U2AF1|U2AF35|splicing factor U2AF 35kDa subunit# s66 COMPLEX Complex_br_(U2AF35/U2AF65) s66 RNA rn1 s66 RNA rn2 s66 RNA rn3 s60 PROTEIN p9 s60 PROTEIN p8 Long Name: U1 Synonym: RNU1,Rnu1a1,U1 SMALL NUCLEAR,snRNA Accession: P01479 s67 PROTEIN p1 s67 RNA rn1 Long Name: U1 Synonym: RNU1,Rnu1a1,U1 SMALL NUCLEAR,snRNA Accession: P01479 s71 PROTEIN p1 Long Name: U2 Synonym: RNU2,U2 SMALL NUCLEAR,snRNA Accession: P01478 s71 PROTEIN p2 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05642 Heterodimer Member Info: U2AF65#PROTEIN#U2AF65#P01475#U2AF65-ASSOCIATED PROTEIN|UAP65#;U2AF35#PROTEIN#U2AF35#P01477#U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35-KD SUBUNIT|U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1|U2AF1|U2AF35|splicing factor U2AF 35kDa subunit# s79 COMPLEX Complex_br_(U2AF35/U2AF65) s72 PROTEIN p8 s72 PROTEIN p9 Long Name: intron Synonym: Synonym not specified Accession: G01560 s79 RNA rn2 Long Name: Exon-1 Synonym: Synonym not specified Accession: G01562 s79 RNA rn1 s34 PROTEIN p4 Long Name: Exon-2 Synonym: Synonym not specified Accession: G01561 s79 RNA rn3 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05642 Heterodimer Member Info: U2AF65#PROTEIN#U2AF65#P01475#U2AF65-ASSOCIATED PROTEIN|UAP65#;U2AF35#PROTEIN#U2AF35#P01477#U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35-KD SUBUNIT|U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1|U2AF1|U2AF35|splicing factor U2AF 35kDa subunit# s93 COMPLEX Complex_br_(U2AF35/U2AF65) s84 PROTEIN p8 s84 PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05642 Heterodimer Member Info: U2AF65#PROTEIN#U2AF65#P01475#U2AF65-ASSOCIATED PROTEIN|UAP65#;U2AF35#PROTEIN#U2AF35#P01477#U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35-KD SUBUNIT|U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1|U2AF1|U2AF35|splicing factor U2AF 35kDa subunit# s91 COMPLEX Complex_br_(U2AF35/U2AF65) s87 PROTEIN p8 s87 PROTEIN p9 inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive Kretchmer Avsian-Kretchmer SRI International Long Name: U1 Synonym: RNU1,Rnu1a1,U1 SMALL NUCLEAR,snRNA Accession: P01479 inside PROTEIN p1 Long Name: U2 Synonym: RNU2,U2 SMALL NUCLEAR,snRNA Accession: P01478 inside PROTEIN p2 Long Name: U4 Synonym: AT-AC FORM,SMALL NUCLEAR RNA U4,U4ATAC Accession: P01476 inside PROTEIN p3 Long Name: U5 Synonym: KIAA0031,U5 snRNP-SPECIFIC PROTEIN Accession: P01474 inside PROTEIN p4 Long Name: U6 Synonym: RNA U6 SMALL NUCLEAR,RNU6 snRNA Accession: P01473 inside PROTEIN p5 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05644 Heterodimer Member Info: U6#PROTEIN#U6#P01473#RNA U6 SMALL NUCLEAR|RNU6 snRNA#;U4#PROTEIN#U4#P01476#AT-AC FORM|SMALL NUCLEAR RNA U4|U4ATAC# inside COMPLEX Complex_br_(U6/U4) Long Name: U2AF35 Synonym: U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35-KD SUBUNIT,U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1,U2AF1,U2AF35,splicing factor U2AF 35kDa subunit Accession: P01477 inside PROTEIN p8 Long Name: U2AF65 Synonym: U2AF65-ASSOCIATED PROTEIN,UAP65 Accession: P01475 inside PROTEIN p9 Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05642 Heterodimer Member Info: U2AF65#PROTEIN#U2AF65#P01475#U2AF65-ASSOCIATED PROTEIN|UAP65#;U2AF35#PROTEIN#U2AF35#P01477#U2 SMALL NUCLEAR RIBONUCLEOPROTEIN AUXILIARY FACTOR 35-KD SUBUNIT|U2 SMALL NUCLEAR RNA AUXILIARY FACTOR 1|U2AF1|U2AF35|splicing factor U2AF 35kDa subunit# inside COMPLEX Complex_br_(U2AF35/U2AF65) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05649 Heterodimer Member Info: U6#PROTEIN#U6#P01473#RNA U6 SMALL NUCLEAR|RNU6 snRNA#;U5#PROTEIN#U5#P01474#KIAA0031|U5 snRNP-SPECIFIC PROTEIN#;U4#PROTEIN#U4#P01476#AT-AC FORM|SMALL NUCLEAR RNA U4|U4ATAC# inside COMPLEX Complex_br_(U4/U6/_br_U5) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05648 Heterodimer Member Info: intron#RNA#intron#G01560##;Exon-2#RNA#Exon-2#G01561##;Exon-1#RNA#Exon-1#G01562## inside COMPLEX Complex (Exon-1/intron/Exon-2) inside COMPLEX Complex (Exon-1/intron/Exon-2) inside COMPLEX Complex (Exon-1/intron/Exon-2) inside COMPLEX Complex (Exon-1/intron/Exon-2) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05645 Heterodimer Member Info: U6#PROTEIN#U6#P01473#RNA U6 SMALL NUCLEAR|RNU6 snRNA#;U5#PROTEIN#U5#P01474#KIAA0031|U5 snRNP-SPECIFIC PROTEIN#;U4#PROTEIN#U4#P01476#AT-AC FORM|SMALL NUCLEAR RNA U4|U4ATAC#;U2#PROTEIN#U2#P01478#RNU2|U2 SMALL NUCLEAR|snRNA#;U1#PROTEIN#U1#P01479#RNU1|Rnu1a1|U1 SMALL NUCLEAR|snRNA# inside COMPLEX Complex(U6/U4/U2/U5/U1) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05643 Heterodimer Member Info: U6#PROTEIN#U6#P01473#RNA U6 SMALL NUCLEAR|RNU6 snRNA#;U5#PROTEIN#U5#P01474#KIAA0031|U5 snRNP-SPECIFIC PROTEIN#;U2#PROTEIN#U2#P01478#RNU2|U2 SMALL NUCLEAR|snRNA# inside COMPLEX Complex(U5/U2/U6) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05646 Heterodimer Member Info: Exon-2#RNA#Exon-2#G01561##;Exon-1#RNA#Exon-1#G01562## inside COMPLEX Complex(Exon-2/Exon-1) Long Name: Long Name: Long name not specified Synonym: Synonym not specified Accession: U05647 Heterodimer Member Info: intron#RNA#intron#G01560##;U6#PROTEIN#U6#P01473#RNA U6 SMALL NUCLEAR|RNU6 snRNA#;U5#PROTEIN#U5#P01474#KIAA0031|U5 snRNP-SPECIFIC PROTEIN#;U2#PROTEIN#U2#P01478#RNU2|U2 SMALL NUCLEAR|snRNA# inside COMPLEX Complex(intron/U2/U5/U6) STATE_TRANSITION a5 a9 a6 STATE_TRANSITION a6 a15 a7 HETERODIMER_ASSOCIATION 0.27805104927320734,0.2829084486543698 a11 a13 a29 STATE_TRANSITION 0.6893984599249947,0.00381709187624768 a110 a81 a80 HETERODIMER_ASSOCIATION 0.28452012115927894,0.39444369277950786 a88 a89 a94 STATE_TRANSITION a85 a94 a5 HETERODIMER_ASSOCIATION -0.005646895050052336,0.37836972258314194 a29 a12 a104 STATE_TRANSITION 0.553133581774579,0.006485811179707923 a108 a110 a47 a45 HETERODIMER_ASSOCIATION 0.0023245133972293885,0.3670444761003404 a7 a104 a108