Panther Pathway: P04397 No pathway definition 4.0 s4 SIMPLE_MOLECULE AMP s4 PROTEIN p1 s15 PROTEIN p5 s15 SIMPLE_MOLECULE GTP s16 PROTEIN p5 s16 SIMPLE_MOLECULE GDP s32 PROTEIN p1 s32 SIMPLE_MOLECULE ATP s26 PROTEIN p9 s26 PROTEIN p10 s11 PROTEIN p3 s11 PROTEIN p4 inactive inactive active inactive inactive inactive inactive inactive active active inactive active inactive inactive active inactive active active inactive inactive inactive inactive active inactive active inactive inactive inactive inactive inactive inactive inactive inactive inactive inactive active inactive inactive inactive inactive inactive active active inactive inactive inactive SRI International Long Name: AMP Synonym: Synonym not specified Accession: S04875 inside SIMPLE_MOLECULE AMP Long Name: AMP-activated protein kinase Synonym: Synonym not specified Accession: P04639 inside PROTEIN p1 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05675 Heterodimer Member Info: AMPK#PROTEIN#AMP-activated protein kinase#P04639##;AMP#SIMPLE_MOLECULE#AMP#S04875## inside COMPLEX Complex_br_(AMP/AMPK) Long Name: AMP-activated protein kinase Synonym: Synonym not specified Accession: P04639 inside PROTEIN p1 Long Name: Serine/threonine protein kinase 11 Synonym: STK11 Accession: P04647 inside PROTEIN p2 Long Name: TSC1 Synonym: Tuberous sclerosis-1 Accession: P04645 inside PROTEIN p4 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05677 Heterodimer Member Info: GTP#SIMPLE_MOLECULE#GTP#S04874##;Rheb#PROTEIN#Ras homolog enriched in brain 2#P04642## inside COMPLEX Complex_br_(Rheb/GTP) Long Name: Long name not specified Synonym: Synonym not specified Accession: U05674 Heterodimer Member Info: GDP#SIMPLE_MOLECULE#GDP#S04872##;Rheb#PROTEIN#Ras homolog enriched in brain 2#P04642## inside COMPLEX Complex_br_(Rheb/GDP) Long Name: Target of rapamycin Synonym: FKBP12-rapamycin complex associated protein 1,FRAP1,TOR Accession: P04638 inside PROTEIN p6 Long Name: S6K Synonym: Ribosomal protein S6 kinase Accession: P04636 inside PROTEIN p7 Long Name: S6K Synonym: Ribosomal protein S6 kinase Accession: P04636 inside PROTEIN p7 Long Name: Eukaryotic translation initiation factor 4E-binding protein 1 Synonym: EIF4EBP1 Accession: P04637 inside PROTEIN p8 Long Name: Eukaryotic translation initiation factor 4E-binding protein 1 Synonym: EIF4EBP1 Accession: P04637 inside PROTEIN p8 Long Name: Translation Synonym: Synonym not specified Accession: U05679 inside PHENOTYPE Translation Long Name: Autophagy Synonym: Synonym not specified Accession: U05683 inside PHENOTYPE Autophagy Long Name: Protein phosphatase 2 catalytic subunit Synonym: Synonym not specified Accession: P04643 inside PROTEIN p10 Long Name: p53 Synonym: Synonym not specified Accession: P04640 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04668|p53 pathway feedback loops 2*P00059|P01485|p53 pathway inside PROTEIN p11 Long Name: p53 Synonym: Synonym not specified Accession: P04640 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04668|p53 pathway feedback loops 2*P00059|P01485|p53 pathway inside PROTEIN p11 Long Name: TSC2 Synonym: Synonym not specified Accession: G04706 inside GENE gn1 Long Name: ATP Synonym: Synonym not specified Accession: S04873 inside SIMPLE_MOLECULE ATP Long Name: Long name not specified Synonym: Synonym not specified Accession: U05672 Heterodimer Member Info: ATP#SIMPLE_MOLECULE#ATP#S04873##;AMPK#PROTEIN#AMP-activated protein kinase#P04639## inside COMPLEX Complex_br_(AMPK/ATP) Long Name: Pi Synonym: Synonym not specified Accession: U05682 inside ION Pi Long Name: alpha4 Synonym: Synonym not specified Accession: P04646 inside PROTEIN p9 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05676 Heterodimer Member Info: PP2A-C#PROTEIN#Protein phosphatase 2 catalytic subunit#P04643##;alpha4#PROTEIN#alpha4#P04646## inside COMPLEX Complex_br_(alpha4/PP2A-C) Long Name: Akt Synonym: ONCOGENE AKT1,ONCOGENE AKT2,PKB,PKB-ALPHA,PKB-BETA,PROTEIN KINASE B-ALPHA,PROTEIN KINASE B-BETA,RAC SERINE/THREONINE PROTEIN KINASE Accession: P04641 Pathway Link: P00033|P00894|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04665|p53 pathway feedback loops 2*P00059|P01486|p53 pathway inside PROTEIN p12 Long Name: TSC2 Synonym: Synonym not specified Accession: P04644 inside PROTEIN p3 Long Name: Long name not specified Synonym: Synonym not specified Accession: U05673 Heterodimer Member Info: TSC2#PROTEIN#TSC2#P04644##;TSC1#PROTEIN#TSC1#P04645#Tuberous sclerosis-1# inside COMPLEX Complex_br_(TSC2/TSC1) Long Name: TSC2 Synonym: Synonym not specified Accession: P04644 inside PROTEIN p3 Long Name: p53 pathway Synonym: Synonym not specified Accession: U05680 inside PHENOTYPE p53 pathway Long Name: Low glucose Synonym: Synonym not specified Accession: U05678 inside UNKNOWN Low glucose inside RNA rn1 Long Name: Insulin singaling pathway Synonym: Synonym not specified Accession: U05681 inside UNKNOWN Insulin signaling pathway HETERODIMER_ASSOCIATION 0.3503352911465113,0.1392569529367509 a4 a5 a8 STATE_TRANSITION a8 a9 a10 STATE_TRANSITION 0.45544554455445546,0.0 a11 a12 a9 HETERODIMER_ASSOCIATION 0.5891566265060242,0.31111111111110956 a12 a13 a17 STATE_TRANSITION 0.5979491075980503,0.0011116443593985892 a22 a23 a46 a17 STATE_TRANSITION a24 a25 a22 STATE_TRANSITION a26 a27 a25 STATE_TRANSITION a28 a29 a25 UNKNOWN_INHIBITION 8.506151142357865E-4,-0.02915289982425273 a28 a30 UNKNOWN_INHIBITION a25 a31 UNKNOWN_TRANSITION a32 a33 a25 HETERODIMER_ASSOCIATION 0.3976452746117731,0.24126944615269785 a33 a34 a37 STATE_TRANSITION a38 a39 a37 STATE_TRANSITION a39 a38 a9 HETERODIMER_ASSOCIATION 0.4412976161997735,0.40332479573530544 a42 a5 a45 DISSOCIATION 0.3605533244087473,0.33574297188754976 a17 a12 a13 a47 KNOWN_TRANSITION_OMITTED a48 a47 DISSOCIATION 0.39963664234736807,0.24764142361005526 a45 a42 a5 a41 DISSOCIATION 0.15213323353293395,0.45659330876353543 a8 a4 a5 PHYSICAL_STIMULATION a27 a30 PHYSICAL_STIMULATION a38 a49 TRANSCRIPTION a40 sa44 a38 STATE_TRANSITION 0.6712871287128707,0.0 a12 a11 sa44